Spectroscopic studies of the inclusion compound of lisinopril withβ-cyclodextrin

Abstract

Abstract. The inclusion compounds of lisinopril with β-cyclodextrin, prepared by different methods: kneading, co-precipitation and freeze-drying were investigated by XRD, FTIR, DSC and solid-state NMR techniques. It was established by these methods that the complexation process was successfully. The degree of crystallinity for the product obtained by kneading was also determined. The kneaded product has a certain crystallinity degree, so it is possible that the inclusion process is less effective in this case. In the case of freeze-dried and co-precipitated products only amorphous phase exists, i.e. the complexation was produced with a higher efficiency.

Formation of Rutin–β-Cyclodextrin Inclusion Complexes by Supercritical Antisolvent Precipitation

“…The intensity of this peak reduces in the case of all SAS RUT–β-CD powders, due to the loss of water molecules in the β-CD cavity replaced by the hydrophobic RUT. Indeed, this replacement allows reaching a lower and more stable energy state with the formation of inclusion complexes [ 48 ].…”

“…The intensity of this peak reduces in the case of all SAS RUT-β-CD powders, due to the loss of water molecules in the β-CD cavity replaced by the hydrophobic RUT. Indeed, this replacement allows reaching a lower and more stable energy state with the formation of inclusion complexes [48]. XRD analyses were also performed on unprocessed RUT and β-CD, and SA cessed RUT-β-CD at different molar ratios (i.e., 172 mol:mol and 1:1 mol:mol), as re in Figure 9.…”

Formulation and In- Vitro Evaluation of Spherical Crystal Agglomerates of Ebastine by Quasi Emulsion Solvent Diffusion Method

“…Pure drug showed sharp endothermic peak at 89 °C corresponding to its melting point (27) . Thermogram of PEG also showed sharp endothermic peak at 65.54°C related to its melting point (31,49) , while βcyclodextrin showed a broad peak at 114.44°C which corresponding to the loss of the water molecules existing in the form of residual humidity as well as those included in the cavity by evaporation, while the peak at 312.43°C corresponds to its melting point (50) . So, the above results indicated the purity and crystallinity of the used materials.…”