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The aim of the present paper was to obtain new solid forms of Norfloxacin. For this purpose Norfloxacin was recrystallized from: acetic acid and its mixtures with several organic solvents. By recrystallization of Norfloxacin from acetic acid and from its mixture with several organic solvents a new solvate was found. To evidence this new solid form of Norfloxacin different investigation techniques were used: powder X-ray diffraction, FTIR, DSC,13C NMR spectroscopy and mass spectrometry. The solvate is consisting on Norfloxacin and acetic acid in 1:1 molar ratio and crystallizes in triclinic system and the cell parameters were determined also.

Abstract. The inclusion compounds of lisinopril with β-cyclodextrin, prepared by different methods: kneading, co-precipitation and freeze-drying were investigated by XRD, FTIR, DSC and solid-state NMR techniques. It was established by these methods that the complexation process was successfully. The degree of crystallinity for the product obtained by kneading was also determined. The kneaded product has a certain crystallinity degree, so it is possible that the inclusion process is less effective in this case. In the case of freeze-dried and co-precipitated products only amorphous phase exists, i.e. the complexation was produced with a higher efficiency.

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