Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs

Dreve, Simina; Kacsó, Irén; Popa, Adriana; Raita, O.; Dragan, Felicia; Bende, Attila; Borodi, Gheorghe; Bratu, Ioan

doi:10.1016/j.molstruc.2011.05.001

Cited by 14 publications

(10 citation statements)

References 26 publications

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“…The amide I and amide II bands are found at 1657 and 1594 cm À1 of the experimental spectrum respectively. These modes are reported by Dreve et al 29 at 1650 cm À1 and 1594 cm À1 . These bands have an increased importance in the systems under study and accurately identifying their origin can be greatly facilitated by theoretical computation.…”

Section: Infrared Spectrasupporting

confidence: 63%

“…These spectra provide a baseline for comparison with corresponding CS NPs with encapsulation of drugs of small molecular weight. We additionally compare the most characteristic bands with the results of Dreve et al 29 on hydrogel samples of CS. The theoretical curves were produced by a suitable Gaussian broadening with a half-width at half-height (HWHH) of 8 cm À1 .…”

Section: Infrared Spectramentioning

confidence: 99%

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Properties and energetics for design and characterization of chitosan nanoparticles used for drug encapsulation

et al. 2014

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Section: Infrared Spectrasupporting

confidence: 63%

Section: Infrared Spectramentioning

confidence: 99%

Properties and energetics for design and characterization of chitosan nanoparticles used for drug encapsulation

et al. 2014

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“…Among them, DCNa, has been extensively used as a model anionic drug in numerous DDS formulations, particularly in CTS-based systems such as tablets, microspheres, microparticles and gels, due to its ionic linkage with CTS at acidic pH [ 29 ]. For example, the preparation of chitosan hydrogels bearing diclofenac, acetylsalycilic acid, and hydrocortisone acetate as anti-inflammatory drugs has been reported [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Reversible pH-Sensitive Chitosan-Based Hydrogels. Influence of Dispersion Composition on Rheological Properties and Sustained Drug Delivery

et al. 2018

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The present work deals with the synthesis of micro-structured biomaterials based on chitosan (CTS) for their applications as biocompatible carriers of drugs and bioactive compounds. Twelve dispersions were prepared by means of functional cross-linking with tricarballylic acid (TCA); they were characterized by Fourier transform infrared spectroscopy (FT-IR), modulated temperature differential scanning calorimetry (MTDSC) and scanning electron microscopy (SEM), and their rheological properties were studied. To the best of the authors’ knowledge, no study has been carried out on the influence of CTS concentration, degree of cross-linking and drug loading on chitosan hydrogels for drug delivery systems (DDS) and is investigated herein for the first time. The influence of dispersion composition (polymer concentration and degree of cross-linking) revealed to exert a marked impact on its rheological properties, going from liquid-like to viscoelastic gels. The release profiles of a model drug, diclofenac sodium (DCNa), as well as their relationships with polymer concentration, drug loading and degree of cross-linking were evaluated. Similar to the findings on rheological properties, a wide range of release profiles was encountered. These formulations were found to display a well-controlled drug release strongly dependent on the formulation composition. Cumulative drug release under physiological conditions for 96 h ranged from 8% to 67%. For comparative purpose, Voltaren emulgel® from Novartis Pharmaceuticals was also investigated and the latter was the formulation with the highest cumulative drug release (85%). Some formulations showed similar spreadability values to the commercial hydrogel. The comparative study of three batches confirmed the reproducibility of the method, leading to systems particularly suitable for their use as drug carriers.

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“…drug delivery system, owing to its special properties: biocompatible, biodegradable, non-toxic and nonimmunogenic [9][10]. At acid pH, its amino groups are ionized, making it hydrosoluble and positively charged; these properties enable it to interact with oppositely charged polymers by intermolecular electrostatic interaction, forming polyelectrolyte complexation.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Methods for Evaluation of Antioxidant Properties of Propolis Extract Incorporated in Chitosan Nanoparticles

Fritea¹,

Pasca²,

Vlase³

et al. 2021

Mater. Plast.

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The main purpose of our study was to demonstrate the antioxidant properties of novel propolis nano-formulation, incorporated in spherical chitosan nanoparticles. The electrochemical methods (cyclic voltammetry and differential pulse voltammetry) were successfully applied to propolis extract and nanopropolis formulation, confirming that the content in phenolic acids and flavonoids is responsible for the antioxidant activity of propolis. The quantitative and qualitative results are also supported by high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectroscopy.

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Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs

Cited by 14 publications

References 26 publications

Properties and energetics for design and characterization of chitosan nanoparticles used for drug encapsulation

Properties and energetics for design and characterization of chitosan nanoparticles used for drug encapsulation

Reversible pH-Sensitive Chitosan-Based Hydrogels. Influence of Dispersion Composition on Rheological Properties and Sustained Drug Delivery

Electrochemical Methods for Evaluation of Antioxidant Properties of Propolis Extract Incorporated in Chitosan Nanoparticles

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