Spectroscopic studies on bis(1-amidino-O-alkylurea) copper(II) sulfate complexes where alkyl=methyl, ethyl, n-propyl or n-butyl: EPR evidence for binuclear complexes

Singh, L. Jaideva; Devi, N. Shantibala; Devi, S. Pramodini; Devi, W. Bembee; Singh, Ritu; Rajeswari, B.; Kadam, R.M.

doi:10.1016/j.inoche.2009.12.023

Cited by 24 publications

(4 citation statements)

References 12 publications

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“…Complex 1 is a mixture of mononuclear and binuclear Cu(II) complexes. Its EPR spectrum is a superposition of spectrum similar to Cu(phen) spectrum and a well resolved doublet, associated with the triplet state ( S = 1, Δ m S = ±1) of binuclear complexes [ 14 , 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruziActivity

Martins

Gouvea

Muniz

et al. 2016

Bioinorganic Chemistry and Applications

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Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen) were prepared and characterized by IR, EPR spectra, molar conductivity, and elemental analyses. The experimental data suggest that norfloxacin was coordinated to copper(II) through the carboxylato and ketone oxygen atoms. The interaction of the copper(II) complexes with bovine serum albumin (BSA) and human serum albumin (HSA) was investigated using fluorescence quenching of the tryptophan residues and copper(II) EPR spectroscopy. The results of fluorescence titration revealed that copper(II) complexes have a moderate ability to quench the intrinsic fluorescence of the albumins through a static quenching mechanism. EPR experiments showed that BSA and HSA Cu(II) sites compete with NOR for Cu(II)-bipy and Cu(II)-phen to form protein mixed-ligand complexes. Copper(II) complexes, together with the corresponding ligands, were evaluated for their trypanocidal activity in vitro against Trypanosoma cruzi, the causative agent of Chagas disease. The tests performed using bloodstream trypomastigotes showed that the Cu(II)-N-donor precursors and the metal complexes were more active than the free fluoroquinolone.

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Section: Resultsmentioning

confidence: 99%

Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruziActivity

Martins

Gouvea

Muniz

et al. 2016

Bioinorganic Chemistry and Applications

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“…For syntheses of dihydropyrimidinones and their analogous, see: Biginelli (1893); Varala et al (2003); Gohain et al (2004); Ahmed et al (2009). For biological activities of hydropyrimidinones, see: Salehi et al (2006); Singh et al (2010); Hed et al (2009); Russowsky et al (2007); Shah et al (2009). For the synthesis of the title compound, see: Ahmed et al (2012 Table 1 Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

“…Dihydropyrimidin-2(1H)-one scaffold compounds are an important class of substances in organic and medicinal chemistry. Aryl-substituted 3, 4-dihydropyrimidin-2(1H)-ones and their sulfur analogue have been reported to possess diverse range of pharmacological activity (Salehi et al, 2006) such as anticancer, anti HIV, antibacterial, antimalarial, antihypertensive, sedative, hypnotics, anticonvulsant, antithyroid,antihistaminic agents and antibiotics (Singh et al, 2010;Hed et al, 2009;Russowsky et al, 2007;Shah et al, 2009). This stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations.…”

Section: Related Literaturementioning

confidence: 99%

Crystal structure of ethyl 4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

et al. 2015

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In the title compound, C15H18N2O3S, the hydropyrimidine ring adopts a sofa conformation with the methine C atom as the flap. The benzene ring is almost perpendicular to the mean plane of the hydropyrimidine ring, making a dihedral angle of 85.51 (8)°, and the methoxy O atom lies over the centre of the pyrimidine ring. In the crystal, weak N—H⋯S interactions form a zigzag chain running along the b-axis direction.

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“…Such signals are characteristic of a mixture of binuclear species, that means species in which two close copper nuclei interact via an intermolecular way, and mononuclear copper species. [60][61][62][63] Fig. 14's right part illustrates the component positions of tensor g (g x , g y and g z ) of binuclear species with the zero-field splitting D and the hyperfine contribution A z for two equivalent copper nuclei.…”

Section: Epr Measurementsmentioning

confidence: 99%

Click synthesis of symmetric bis-triazol ligands and full characterisation of their copper(ii)-complexes

et al. 2014

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Spectroscopic studies on bis(1-amidino-O-alkylurea) copper(II) sulfate complexes where alkyl=methyl, ethyl, n-propyl or n-butyl: EPR evidence for binuclear complexes

Cited by 24 publications

References 12 publications

Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruziActivity

Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruziActivity

Crystal structure of ethyl 4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Click synthesis of symmetric bis-triazol ligands and full characterisation of their copper(ii)-complexes

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