Spectrum of Esophageal Motility Disorders

Patti, Marco G.; Gorodner, M. V.; Galvani, Carlos; Tedesco, Pietro; Fisichella, P. Marco; Ostroff, James W.; Bagatelos, Karen C.; Way, Lawrence W.

doi:10.1001/archsurg.140.5.442

Cited by 87 publications

(29 citation statements)

References 21 publications

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“…Patti et al [20] reported that among 397 patients with primary esophageal motility disorders, the symptoms neither distinguished motility disorders from reflux nor did they distinguish between different motility disorders. By contrast, Hong et al [21] divided 462 patients into 4 symptom categories (dysphagia, noncardiac chest pain, gastroesophageal reflux disease-related, and extraesophageal symptoms) and stated that these categories are helpful in predicting the likelihood of abnormal manometric findings.…”

Section: Discussionmentioning

confidence: 99%

Insights Gained from Symptom Evaluation of Esophageal Motility Disorders: A Review of 4,215 Patients

et al. 2012

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Background/Aims: Achalasia (Ach), diffuse esophageal spasm (DES), nutcracker esophagus (NE), and nonspecific motility disorder (NSMD) are described primary esophageal body motility disorders; however, their clinical symptom correlation is poorly understood. The aim of this study is to examine the association between a patient’s presenting symptoms and their manometric diagnosis. Methods: Manometric findings and reported symptoms of all patients undergoing esophageal manometry at the Creighton University Medical Center were prospectively entered in a database. Twenty-four-year data from 1984 through 2008 were accessed and analyzed. Results: Of the 4,215 patients, 130 (3.1%) had Ach, 192 (4.6%) had DES, 290 (6.9%) had NE, 508 (12.1%) had NSMD, and 3,095 (73.4%) had normal esophageal body motility. There was significant symptom overlap between the groups. Ach and DES had a similar symptom distribution, with dysphagia being the predominant symptom. Patients with NE, normal body motility, and NSMD presented predominantly with reflux symptoms. There was an increasing prevalence of esophageal dysmotility (DES and NSMD) with age, and women were found to be more likely to have NE than men. Conclusion: In an individual, reported symptoms do not correlate with their manometric diagnosis in a predictable fashion, and a thorough physiological assessment should be obtained to understand and diagnose the disease process. Esophageal motility deteriorates with age.

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Section: Discussionmentioning

confidence: 99%

Insights Gained from Symptom Evaluation of Esophageal Motility Disorders: A Review of 4,215 Patients

et al. 2012

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“…Clinical symptoms have been found to be unreliable in assessing the success of therapy since achalasia patients often have a charmed deception with any therapy and express dramatic clinical benefit from small degrees of improved emptying. [7][8][9] The TBS has been described as an objective test to assess esophageal emptying. The test was initially used to assess improvement in emptying in patients who underwent pneumatic dilatation or botulinum toxin injection.…”

Section: Discussionmentioning

confidence: 99%

An Improved Method of Assessing Esophageal Emptying Using the Timed Barium Study Following Surgical Myotomy for Achalasia

Oezcelik

Hagen

Halls

et al. 2009

Journal of Gastrointestinal Surgery

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“…On the other hand, chest pain is the most common complaint of patients with NE. 40 For this reason, the majority of NE patients are referred to a gastroenterologist or a surgeon after a proper workup has excluded the presence of cardiac pathology.…”

Section: Other Primary Esophageal Motility Disordersmentioning

confidence: 99%

Achalasia and Other Esophageal Motility Disorders

Patti

Herbella

2011

Journal of Gastrointestinal Surgery

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Achalasia, diffuse esophageal spasm, nutcracker esophagus, and the hypertensive lower esophageal sphincter are considered primary esophageal motility disorder. These disorders are characterized by esophageal dysmotility that is responsible for the symptoms. While there is today a reasonable consensus about the pathophysiology, the diagnosis, and the treatment of achalasia, this has not occurred for the other disorders. A careful evaluation is therefore necessary before an operation is considered.

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Spectrum of Esophageal Motility Disorders

Cited by 87 publications

References 21 publications

Insights Gained from Symptom Evaluation of Esophageal Motility Disorders: A Review of 4,215 Patients

Insights Gained from Symptom Evaluation of Esophageal Motility Disorders: A Review of 4,215 Patients

An Improved Method of Assessing Esophageal Emptying Using the Timed Barium Study Following Surgical Myotomy for Achalasia

Achalasia and Other Esophageal Motility Disorders

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