Spectrum of Flurodeoxyglucose Positron Emission Tomography/Computerized Tomography Findings in Tumors and Tumor-Like Conditions of the Musculoskeletal System

Purandare, Nilendu; Shah, Sneha; Agrawal, Archi; Puranik, Ameya; Rangarajan, Venkatesh

doi:10.4103/ijnm.ijnm_242_20

Cited by 2 publications

(2 citation statements)

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“…FDG uptake is higher in soft tissue sarcomas than in benign tumors 20 . However, even in benign tumors, high histiocyte or lymphocyte infiltration may lead to high FDG uptake and overdiagnosis 21 . DF is known as one of the benign soft tissue tumors with high histiocytic and lymphoplasmacytic infiltration 22 .…”

Section: Discussionmentioning

confidence: 99%

“…20 However, even in benign tumors, high histiocyte or lymphocyte infiltration may lead to high FDG uptake and overdiagnosis. 21 DF is known as one of the benign soft tissue tumors with high histiocytic and lymphoplasmacytic infiltration. 22 Because of these worrisome clinical and radiological features, we suspected malignancy before preoperative biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Metastasizing aneurysmal dermatofibroma initially diagnosed as angiosarcoma confirmed by CD63::PRKCD fusion gene detection with nanopore sequencing

Takeda,

Makise,

Lin

et al. 2024

Genes Chromosomes & Cancer

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Dermatofibroma (DF) is a benign tumor that forms pedunculated lesions ranging in size from a few millimeters to 2 cm, usually affecting the extremities and trunks of young adults. Histopathologically, DF is characterized by the storiform proliferation of monomorphic fibroblast‐like spindle cells. In addition to neoplastic cells, secondary elements such as foamy histiocytes, Touton‐type giant cells, lymphoplasmacytes, and epidermal hyperplasia are characteristic histological features. Several histological variants, including atypical, cellular, aneurysmal, and lipidized variants, have been reported; cases with variant histologies are sometimes misdiagnosed as sarcomas. We present a case of metastasizing aneurysmal DF that was initially diagnosed as an angiosarcoma on biopsy. A 26‐year‐old woman was referred to our hospital with a gradually enlarging subcutaneous mass in her lower left leg. Positron emission tomography‐computed tomography revealed high fluorodeoxyglucose uptake not only in the tumor but also in the left inguinal region. On biopsy, ERG and CD31‐positive atypical spindle cells proliferated in slit‐like spaces with extravasation, leading to the diagnosis of angiosarcoma. Histology of the wide‐resection specimen was consistent with DF, and lymph node metastasis was also observed. Nanopore DNA sequencing detected CD63::PRKCD fusion and copy number gain, although CD63 was not included in the target region of adaptive sampling. This report highlights the importance of recognizing the unusual clinical, radiological, and pathological features of DF to avoid misdiagnosis, and the potential diagnostic utility of nanopore sequencer.

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Section: Discussionmentioning

confidence: 99%