Spectrum of Lesions of Gall BladderExperience of Five Years at Tertiary Care Hospital

Patil, Milind V; Londhe, Mangesh Machindra; Margam, Sangeeta; Iqbal, Javed

doi:10.21276/apalm.2065

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…Gall bladder lesions were more frequently found in patients who were between the ages of 31 and 40 (4th decade) (Table 2). Similar research was done by Kulkarni et al and Patil et al 6,11 However, Kothastane et al indicated that the age range of 41 to 50 years had the greatest number of patients. 12 In Kothastahne et al's study, the neoplastic diagnosis was made in patients older than 60 years of age, however in the current investigation, 3 out of 8 adenocarcinomas were discovered in patients between the ages of 51 and 60, followed by 71 to 80.…”

Section: Discussionsupporting

confidence: 71%

“…The findings of Patil et al and Kothsthane et al, who found lower incidences of acute cholecystitis of 2.9% and 1.16%, respectively, stand in contrast to this conclusion (Table 3). 6,12 In our study, 0.81% of the patient population had cholesterolosis. This is in contrast to a study done in Pakistan, which found a greater percentage of 32.8% of people had this condition.…”

Section: Discussionmentioning

confidence: 48%

“…The male to female ratio was 1: 2.1, which is comparable to research by Patil et al that showed a male to female ratio of 1:3.2, indicating female preponderance. 6 Gall stones are thought to be more likely to form in women because estrogen triggers the release of biliary cholesterol, which makes bile more hypersaturated with cholesterol and increases the risk of cholelithiasis. 3,10 The patients ranged in age from 3 to 89 years old.…”

Section: Discussionmentioning

confidence: 99%

“…This result is consistent with those of other studies. 6,11,12 Chronic cholecystitis, which encompasses conditions like gangrenous cholecystitis, follicular cholecystitis, and suppurative cholecystitis, is characterised by thickening of the GB wall as well as calcifications caused by cholelithiasis as the primary etiology. 27.78% of patients had acute cholecystitis.…”

Section: Discussionmentioning

confidence: 99%

“…By using histological analysis to detect gall bladder cancer early, the prognosis and survival chances of the patient might be improved. 6 Hence, the objective of this retrospective single centre study is to perform the histopathological analysis of the cholecystectomy specimens over a time period of 6 yearduration to rule out the incidence of gall bladder carcinoma in the patients.…”

Section: Introductionmentioning

confidence: 99%

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A retrospective single centre study on histopathological analysis of cholecystectomy specimens in a tertiary care centre in India

Degloorkar,

Parab,

Shah

et al. 2023

Int Surg J

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Background: Gall bladder carcinoma is the 5th most common gastrointestinal malignancy which has a poor 5-year survival rate, carrying dismal prognosis. Diagnosing chronic cholecystitis from gall bladder cancer is challenging. Early detection of gall bladder carcinoma allows for the possibility of radical resection surgery, which has been shown to increase patient survival. Methods: A retrospective histopathological analysis was conducted at a tertiary care centre to evaluate the incidence of gall bladder carcinoma. A total of 1728 cholecystectomy samples were evaluated from all age groups for a period of 6 years. Results: Chronic cholecystitis was the most common impression on histopathological analysis, showing females have high predominance of developing gall bladder disease including malignancy. The incidence of gall bladder carcinoma was found to be 0.46 % with 8 cases of adenocarcinoma diagnosed, which were not diagnosed preoperatively. Conclusions: If missed, gall bladder cancer can progress rapidly and has a significant fatality risk if it is not detected in time. We conclude that all histopathology specimens be sent for routine analysis, to rule out gall bladder cancer, which if resected early can improve the survival of the patients.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A retrospective single centre study on histopathological analysis of cholecystectomy specimens in a tertiary care centre in India

Degloorkar,

Parab,

Shah

et al. 2023

Int Surg J

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Histopathological spectrum of gall Bladder diseases in cholecystectomy specimens at a Rural tertiary hospital of Purvanchal in North India-Does it differ from South India?

Kotasthane¹,

Kotasthane²

2020

ACHR

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Gall Bladder (GB) diseases are one of the most common digestive system diseases, the prevalence of which is variable within India and ranges from 2-29%. Cholelithiasis (gallstones) is the commonest lesion and accounts for more than 95% of GB diseases. Gall bladder carcinoma showed regional differences in India with prevalence ranging from 0.52% in southern India and as high as 9.6% in northern India. 1)To identify the morphological spectrum of diseases affecting the gall bladder. 2)To identify the most common histopathological lesion and its correlation with clinical and demographic data of the patient. 3)T o identify the frequency of Gall Bladder Carcinoma (GBC) and its correlation with clinical and demographic data of the patient and pre-existing lesions if any. This study was non-participatory descriptive study carried out retrospectively for a period of one year in the Dept. of Pathology, HIMS,from August 2018 to July 2019. All the specimens received in the study period were included in the study. The gross and microscopic findings on H & E slide were included in the study. The descriptive statistics w as applied to analysed data. Total 86 cholecystectomy specimens were received in the Department of Pathology during one year study period. Non-neoplastic lesions (97.67%) of gall bladder outnumbered the neoplastic lesions (2.33%). Most common histopathological lesion was chronic cholecystitis (95.34%). Varied histopathological spectrum was seen comprising of chronic calculous cholecystitis (73.26%), chronic acalculous cholecystitis (13.95), chronic cholecystitis with cholesterosis (13.95%), Xanthogranulomatous cholecystitis (2.33)%), Acute calculous cholecystitis (1.16%), acute gangrenous GB (1.16%), GBC (2.33%). In non-neoplastic lesions, female predilection (70.24%) was seen over male (29.76%) accounting for F:M ratio of 2.4:1, two cases of GBC exclusively seen in females associated with gall stones. Non-neoplastic lesions were common between the age group of 26-50 years accounting for 67.45% where as neoplastic lesions were common in the age group of >60years. Chronic cholecystitis with pigmented gall stone was the commonest GB disease in the present study. The study also revealed that females have increased preponderance for the development of all the gall bladder diseases including malignancy. Non-neoplastic lesions were more common till 5 decade in the present study whereas females in the 5th and 6th decade of life were prone for malignancy of gall bladder which was associated with gall stones.

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Histopathological Spectrum of Gallbladder Diseases in A Tertiary Care Center – A Retrospective Study

Kanimozhi

Sofiya.³

et al. 2021

ijsr

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BACKGROUND: Gallbladder disease is known to affect a substantial number of people throughout the world. In India, the disease prevalence is on the rise, largely attributable to dietary & lifestyle changes, thus causing a signicant disease burden. The purpose of this study is to evaluate the varied histological manifestations of gallbladder pathology and their association with cholelithiasis. MATERIALS & METHODS: This retrospective study was conducted in the department of pathology, Kilpauk medical college from January 2018 to December 2018. The clinical data and the histopathological changes were evaluated. RESULTS: Of the 156 cases which were studied, 120 cases (77%) had gallstones. The mean age was 47 years. Females had a slight preponderance for gallbladder diseases with the Male: Female ratio being 1:2. 138 cases (89.8%) were diagnosed as chronic cholecystitis. 3 cases were diagnosed to have invasive malignancies. CONCLUSION: A diverse spectrum of diseases affect the gallbladder encompassing inammatory conditions, parasitic infections, pseudoneoplastic lesions and neoplasms. Routine cholecystectomy specimens should be evaluated meticulously as incidental ndings and diagnosis can be transformative.

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Spectrum of Lesions of Gall BladderExperience of Five Years at Tertiary Care Hospital

Cited by 4 publications

References 11 publications

A retrospective single centre study on histopathological analysis of cholecystectomy specimens in a tertiary care centre in India

A retrospective single centre study on histopathological analysis of cholecystectomy specimens in a tertiary care centre in India

Histopathological spectrum of gall Bladder diseases in cholecystectomy specimens at a Rural tertiary hospital of Purvanchal in North India-Does it differ from South India?

Histopathological Spectrum of Gallbladder Diseases in A Tertiary Care Center – A Retrospective Study

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