Spectrum of neuroendocrine carcinomas of the uterine cervix, including histopathologic features, terminology, immunohistochemical profile, and clinical outcomes in a series of 50 cases from a single institution in India

Rekhi, Bharat; Patil, B. V; Deodhar, Kedar; Maheshwari, Amita; Kerkar, Rajendra; Gupta, Sudeep; Tongaonkar, Hemant; Shrivastava, Shyam Kishore

doi:10.1016/j.anndiagpath.2012.01.009

Cited by 53 publications

(36 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rekhi et al , in a series of 50 neuroendocrine tumours of the cervix, reported seven cases of collision tumours of SCNEC with other tumours. The other component was SCC in four of the cases, adenocarcinoma in two and large cell neuroendocrine carcinoma in one of the tumours 4. The patients with SCC and SCNEC ranged in age from 45 to 60 years with a median age of 51 years.…”

Section: Discussionmentioning

confidence: 95%

Coexisting squamous cell carcinoma and high-grade neuroendocrine carcinoma, small cell type: a rare collision in cervix

Kaushal¹,

Mathur

Kumar

2018

BMJ Case Reports

View full text Add to dashboard Cite

Collision tumours of the uterine cervix are extremely uncommon with exact incidence not known. Unlike squamous cell carcinoma (SCC) and adenocarcinoma that are known to coexist, small cell neuroendocrine carcinoma (SCNEC) is rarely documented with other histological types in the cervix. We report such rare case of a collision tumour in cervix displaying dual histological component of SCNEC and SCC in a 36-year-old woman. The case is being presented because of its rarity and represents a unique and hitherto seldom-reported combination of two malignant tumours with distinct and often contrasting epidemiology, histology and prognosis coexisting in the same patient.

show abstract

Section: Discussionmentioning

confidence: 95%

Coexisting squamous cell carcinoma and high-grade neuroendocrine carcinoma, small cell type: a rare collision in cervix

Kaushal¹,

Mathur

Kumar

2018

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…The growth pattern of LCNC is an insular, organoid, trabecular or solid pattern, often with peripheral palisading or rosette formation, and focal tumor necrosis is observed. The immunohistochemically positive rates in LCNC are 87% for chromogranin, 56% for synaptophysin, and 88% for at least one of chromogranin, synaptophysin or NSE [19].…”

Section: Discussionmentioning

confidence: 99%

“…Pathologically, LCNC should be distinguished from atypical carcinoids, SCNC, SCC and adenocarcinoma. It was reported that 8/23 of uterine cervix LCNCs were histologically diagnosed as mixed type, coexistent with SCNC, adenocarcinoma or SCC [19]. Thus, adequately sized biopsy is necessary for accurate diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Neuroendocrine Carcinoma of the Uterine Cervix Treated With Complete Surgical Resection and Adjuvant Combination Chemotherapy

Nishio

Miyatake

Yasuoka

et al. 2017

J Clin Gynecol Obstet

View full text Add to dashboard Cite

We describe our experience with one case of cervical large cell neuroendocrine carcinoma (LCNC), with an attempt of an adjuvant chemotherapy after complete surgery. The patient was a 66-year-old female (gravida 3, para 2) presenting with genital bleeding. A cervical mass was diagnosed as high-grade neuroendocrine carcinoma. Radical hysterectomy, pelvic lymph node dissection and bilateral salpingooophorectomy were performed as primary treatment for the cervical cancer. The surgical specimen of the uterus had an enlarged cervix of 4 cm in diameter with parametrial invasion. Microscopically, the surgical specimen exhibited invasive proliferation of relatively large tumor cells. Peripheral nuclear palisading and central necrosis were also histologically observed. Tumor cells had abundant cytoplasm with vesicular nuclei. The final pathological conclusion was high-grade neuroendocrine carcinoma (LCNC). The postoperative diagnosis was cervical cancer, high-grade neuroendocrine carcinoma (LCNC), pT2b-N0M0, FIGO stage IIB, ly (+), v (+). Adjuvant treatment with cisplatin and irinotecan was planned at 4-week intervals. With the completion of three cycles of adjuvant chemotherapy, there was no evidence of recurrent disease. We determined the adjuvant therapy to be effective and well tolerated, and the therapy is now planned to be continued. In conclusion, we experienced a rare case of uterine cervical LCNC. It was surgically resected completely, and adjuvant chemotherapy has been continued. Adjuvant combination chemotherapy with cisplatin and irinotecan is expected to improve the prognosis of cervical LCNC.

show abstract

“…Relatively large series were reported in the gastroenteropancreatic (GEP) area, including the esophagus [6], stomach [7,8], colon and rectum [9], and pancreas [10]. In addition, EPNECs of the small or large type were investigated in the prostate [11,12], bladder [13] and uterine cervix [14,15]. Overall, EPNECs account for no more than 3% of all malignancies in individual anatomical sites.…”

Section: Relevant Issues and Possible Solutions 21 Issue 0: Organ Dmentioning

confidence: 99%

Extrapulmonary neuroendocrine small and large cell carcinomas: a review of controversial diagnostic and therapeutic issues

et al. 2014

View full text Add to dashboard Cite

Summary Extrapulmonary neuroendocrine carcinoma (EPNEC) is a heterogeneous and rare group of high-grade neoplasms occurring in different organs. They usually share a poor prognosis, but diagnostic and therapeutic options still include several controversial issues, due to the rarity of this condition and to differences in architecture and cell size, being some cases pure small cell carcinomas, other pure large cell neuroendocrine carcinomas and some others combined/mixed neuroendocrine carcinomas with a conventional non-neuroendocrine carcinoma. In addition, the therapeutic strategy varies in different organs (surgery and/or chemotherapy and/or radiation therapy and/or targeted treatments), and clinicians and pathologists are asked to interact to reach an accurate classification of every single case, as well as the most appropriate selection of the treatment options, even considering different time points of each EPNEC natural history. This overview highlights controversial pathological and clinical issues and summarizes possible solutions to most of such EPNEC-related problems.

show abstract

Spectrum of neuroendocrine carcinomas of the uterine cervix, including histopathologic features, terminology, immunohistochemical profile, and clinical outcomes in a series of 50 cases from a single institution in India

Cited by 53 publications

References 18 publications

Coexisting squamous cell carcinoma and high-grade neuroendocrine carcinoma, small cell type: a rare collision in cervix

Coexisting squamous cell carcinoma and high-grade neuroendocrine carcinoma, small cell type: a rare collision in cervix

Primary Neuroendocrine Carcinoma of the Uterine Cervix Treated With Complete Surgical Resection and Adjuvant Combination Chemotherapy

Extrapulmonary neuroendocrine small and large cell carcinomas: a review of controversial diagnostic and therapeutic issues

Contact Info

Product

Resources

About