Spectrum of non-infectious erythematous, papular and squamous lesions of the skin

Costa, Grace; Bharambe, Bhavana M

doi:10.4103/0019-5154.70666

Cited by 31 publications

(32 citation statements)

References 18 publications

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“…Lesions with epidermal changes were categorized into interface dermatitis (60 cases), psoriasiform dermatitis (58 cases), and spongiotic dermatitis (16 cases). Chaudhary et al 5 and D'Costa et al 6 reported a similar incidence of interface dermatitis to our study. The predominant histological features of hyperkeratosis, acanthosis, lichenoid infiltrate, and pigment incontinence were reported in this study, corroborated with the observations made by Hegde et al 7 In psoriasiform dermatitis, most histological features in the epidermis were similar to the findings reported by Raghuveer et al 8 Munro's microabscesses are not found in early lesions of psoriasis and were reported only in 6.9% cases in the present study.…”

Section: Papular/non-vb Lesionssupporting

confidence: 91%

Inflammatory Dermatoses of the Superficial Cutaneous Reactive Unit—Study of Morphological Features with Clinical Correlation

Raj¹,

Dinesh²,

Kumar³

2019

The Journal of Medical Sciences

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Background and objectives: Inflammatory dermatoses of the superficial cutaneous reactive unit are a common and complex variety of clinical conditions. This study was undertaken to perform a detailed morphological evaluation of lesions classified in this category, and to correlate the clinical details to arrive at the most appropriate diagnosis. Methodology: Skin biopsies of clinically diagnosed/suspected cases of inflammatory dermatoses were processed and stained with hematoxylin and eosin (H&E), followed by microscopic examination. Results: A total of 160 skin biopsies of superficial inflammatory dermatoses were studied. Lesions were categorized into papular/nonvesiculobullous (non-VB) (142 cases/88.75%) and VB (18 cases/11.25%) lesions. Papular lesions were frequent in males, with a peak incidence in the fourth decade. Patients presented mostly with pigmented plaques and papules over the extremities. Papular lesions were categorized based on epidermal changes: 8 cases without epidermal changes and 134 with epidermal changes. Lesions with epidermal changes were further categorized into interface dermatitis (60 cases), psoriasiform dermatitis (58 cases), and spongiotic dermatitis (16 cases). Commonly reported lesions were lichen planus (LP) with its variants followed by psoriasis vulgaris. VB lesions were common in the third and fourth decades, predominantly in females. These patients presented mostly with generalized vesicles. Common lesions reported were erythema multiforme (seven cases) and pemphigus vulgaris (six cases). Of the 160 cases, clinicopathological concordance was seen in 156 cases (97.5%) and discordance in 4 cases (2.5%). Interpretation and conclusion: The incidence of superficial inflammatory dermatoses in our study was comparable with those reported in other studies. Despite advances in molecular techniques, morphology remains the gold standard for the diagnosis and prognosis of many inflammatory dermatoses. This study emphasizes the importance and utility of a systematic approach to superficial inflammatory dermatoses which is relevant from the treatment perspective.

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Section: Papular/non-vb Lesionssupporting

confidence: 91%

Inflammatory Dermatoses of the Superficial Cutaneous Reactive Unit—Study of Morphological Features with Clinical Correlation

Raj¹,

Dinesh²,

Kumar³

2019

The Journal of Medical Sciences

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“…D'Costa et al noted positive correlation in 97.52% cases and a negative correlation in 2.48 % cases. 3 In the present study, histopathology confirmed diagnosis in 90% cases while histopathology gave diagnosis in 10% of the cases. Inaloez stated that the diagnostic rate increased up to 100% by the presence of clinical information and histological examination.…”

Section: Discussionsupporting

confidence: 55%

“…3 Henseler et al identified two ages of onset: type I occuring at or before the age of 40years in approximately 75% of the patients; and type II presenting after the age of 40years. 5 Gudjonsson et al stated that type I psoriasis is HLA-associated, while type II lacks HLA association.…”

Section: Discussionmentioning

confidence: 99%

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Papulosquamous: clinicopathological

Narayankar

Pandit

2017

Int J Res Med Sci

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Background: Papulosquamous disorders comprise a group of dermatoses that have distinct morphologic features. The characteristic primary lesion of these disorders is a papule, usually erythematous, that has a variable amount of scaling on the surface. Some common papulosquamous dermatoses are Psoriasis, Pityriasis rosea, Lichen planus, Seborrheic dermatitis, Pityriasis rubra pilaris and Parapsoriasis. Drug eruptions, tinea corporis, and secondary syphilis may also have papulosquamous morphology. Because all papulosquamous disorders are characterized by scaling papules, clinical confusion may result during their diagnosis.Methods: The present study of 60 cases of papulosquamous disorders of the skin was carried out in the Department of Pathology of a tertiary care centre from December 2009 to October 2011. In this study, the patients which were clinically diagnosed as papulosquamous disorders of skin, before starting the treatment and attending the outdoor skin department were selected. Histopathological findings were interpreted in light of clinical details.Results: An analysis of the clinical diagnosis with the histopathological diagnosis of papulosquamous disorders of the skin, revealed a positive correlation in 54 (90%) cases and a negative correlation in 6 (10%) cases.Conclusions: Histopathology may not resolve the issue and the picture is more typically ‘compatible with’ rather than ‘diagnostic of’ a clinical diagnosis. In these circumstances an attempt at clinicohistopathological correlation serves as an ideal approach.

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“…Lichenoid lesions was the most common histopathological diagnosis reported in the present study (26%) followed by Hansen's disease (23.9%). In the study by Bharambhe et al 7 lichenoid lesions were commonest (46.57%) followed by psoriasis (19.88%). In the study by Singh et al, 27.9% of the cases were diagnosed as nonspecific dermatoses followed by granulomatous lesions (23.5%).…”

Section: Discussionmentioning

confidence: 99%