Spectrum of pediatric malignancy- A cancer hospital-based study

Abstract

Objective: Childhood malignancy being a significant cause of mortality among children. The aim of the study is to find out the epidemiology of tumours in children in our region below <14 years age who presented to tertiary care Cancer hospital, Bhopal, M.P. for period of four years (2015)(2016)(2017)(2018). Methodology: All children with cancer, aged 1-14 years diagnosed by mean of histological and cytological examination during a period of 4 years were reviewed. Results: During the period of four years 275 patients were diagnosed as having paediatric malignancies. According to year wise distribution highest incidence of cases were found in 2016 (32.72%). The highest number of cases, 96(35%) were in 10-14 years of age group and mean age was 7.43 with SD 4.0. Male were affected more than females with ratio of 2.66:1. It was observed that haematological malignancies were more common 172(62.54%) than the non haematological malignancies 103(37.45%). Leukemia 150 (54.54%) is most common pediatric cancer amongst which Acute lymphoblastic leukemia is most common haematological malignancy. Overall, it was found that most common cancer group in the present study were leukemia (54%) followed by lymphoma (8.36%), Brain tumours (7.27%) and Sarcoma (7.27%). Conclusion: Although the exact incidence rate cannot be provided by this hospital-based study, the information is useful in showing distribution patterns of childhood malignancy in this region.

Clinical Profile of Pediatric Oncology Patients Treated by Radiotherapy: A Retrospective Audit from a Tertiary Cancer Care Center in South India

“…In a similar study conducted by Dasgupta et al 8 at a referral hospital in Kolkata, West Bengal, India, it was found that 49.39% were cases of hematological malignancies and the rest were nonhematological malignancies. ALL was the most common hematolymphoid malignancy (26.1%) and brain tumor (27.8%) was the most common solid tumor in our study population, which is also consistent with the study results reported by Gupta et al 7 wherein ALL constituted 44.3% of cases and brain tumor constituted 7.27% of cases. Dasgupta et al 8 in their study found that 25.08% of cases had ALL and among nonhematologic malignancies retinoblastoma was the most common tumor (10.62%).…”

“…7 Although the reason for this difference is not fully understood, it is thought that potential genetic and hormonal factors may be implicated in causing higher incidence among males. 7 Results of the present study depicted that 41.7% of the cases had hematolymphoid malignancy and 58.3% had solid tumors. In a similar study conducted by Dasgupta et al 8 at a referral hospital in Kolkata, West Bengal, India, it was found that 49.39% were cases of hematological malignancies and the rest were nonhematological malignancies.…”

“…7 Although the reason for this difference is not fully understood, it is thought that potential genetic and hormonal factors may be implicated in causing higher incidence among males. 7…”

“…Various studies in India have consistently shown a higher incidence of pediatric cancers among males. 7 Although the reason for this difference is not fully understood, it is thought that potential genetic and hormonal factors may be implicated in causing higher incidence among males. 7 Results of the present study depicted that 41.7% of the cases had hematolymphoid malignancy and 58.3% had solid tumors.…”