Objective: Childhood malignancy being a significant cause of mortality among children. The aim of the study is to find out the epidemiology of tumours in children in our region below <14 years age who presented to tertiary care Cancer hospital, Bhopal, M.P. for period of four years (2015)(2016)(2017)(2018). Methodology: All children with cancer, aged 1-14 years diagnosed by mean of histological and cytological examination during a period of 4 years were reviewed. Results: During the period of four years 275 patients were diagnosed as having paediatric malignancies. According to year wise distribution highest incidence of cases were found in 2016 (32.72%). The highest number of cases, 96(35%) were in 10-14 years of age group and mean age was 7.43 with SD 4.0. Male were affected more than females with ratio of 2.66:1. It was observed that haematological malignancies were more common 172(62.54%) than the non haematological malignancies 103(37.45%). Leukemia 150 (54.54%) is most common pediatric cancer amongst which Acute lymphoblastic leukemia is most common haematological malignancy. Overall, it was found that most common cancer group in the present study were leukemia (54%) followed by lymphoma (8.36%), Brain tumours (7.27%) and Sarcoma (7.27%). Conclusion: Although the exact incidence rate cannot be provided by this hospital-based study, the information is useful in showing distribution patterns of childhood malignancy in this region.

Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality; in fact, some studies showed a higher prevalence of major, previous and new-onset, cardiovascular, and cerebrovascular events in diabetic patients with foot ulcers than in those without these complications. This is consistent with the fact that in diabetes there is a complex interplay of several variables with inflammatory metabolic disorders and their effect on the cardiovascular system that could explain previous reports of high morbidity and mortality rates in diabetic patients with amputations. Involvement of inflammatory markers such as IL-6 plasma levels in diabetic subjects confirmed the pathogenetic issue of the “adipovascular” axis that may contribute to cardiovascular risk in patients with type 2 diabetes. In patients with diabetic foot, this “adipovascular axis” expression in lower plasma levels of adiponectin and higher plasma levels of IL-6 could be linked to foot ulcers pathogenesis by microvascular and inflammatory mechanisms. The purpose of this review is to focus on the immune inflammatory features of DFS and its possible role as a marker of cardiovascular risk in type 2 diabetes patients.

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