Speech and language disorders secondary to diffuse subcortical vascular lesions: Neurolinguistic and acoustic analysis. A case report

Tomić, Gordana; Stojanović, Milena; Pavlović, Aleksandra M.; Stanković, P.; Zidverc-Trajković, Jasna; Pavlović, Dušan; Marković-Jovanović, Zagorka; Covickovic-Sternic, Nadezda

doi:10.1016/j.jns.2009.02.361

Cited by 11 publications

(6 citation statements)

References 20 publications

(29 reference statements)

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“…Given that many language-based cognitive processes are primarily cortical in nature, this finding is somewhat surprising. However, subcortical μVBI is associated with impairments in speech production, language processing, and naming [48–50], consistent with our finding that subcortical microvascular lesions may be associated with reduced performance on the language composite.…”

Section: Discussionsupporting

confidence: 87%

“…Language functions are quite variable and can be disrupted by multiple pathological processes. For example, semantic processing is commonly disrupted in AD patients, while subcortical μVBI is associated with impairments in speech production, language processing, and naming [48–50]. LBD also is associated with disrupted language, but such impairments differ qualitatively from AD and may be influenced by reduced fluency, impaired sentence processing, and slowed speech [51, 52].…”

Section: Discussionmentioning

confidence: 99%

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Neuropathologic Correlates of Cognition in a Population-Based Sample

Cholerton

Larson

Baker

et al. 2013

JAD

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Many cognitively normal older adults have underlying neuropathologic changes of Alzheimer’s disease (AD), vascular brain injury (VBI), or Lewy body disease (LBD), which confer an increased risk of dementia. The current study focused on the association between multiple neuropathologic indices and performance on specific cognitive domains in a community sample of older adults. Of 438 participants in the Adult Changes in Thought population-based study of brain aging who were autopsied, 363 subjects had cognitive testing at their final study visit and were included. Associations were measured between performance on the Cognitive Abilities Screening Instrument prior to death and neuropathologic endpoints, including AD neuropathologic changes, LBD, cerebral amyloid angiopathy, and measures of VBI. Braak stage for neurofibrillary tangles, lower brain weight, and VBI as measured by cerebral cortical microvascular lesions (μVBI) explained a significant proportion of the variance associated with global cognitive test performance (R2=0.31, p< 0.0001) both in the entire sample and when analysis was restricted to non-demented subjects (R2= 0.23, p< 0.0001). Specific cognitive domains were differentially related to neuropathologic lesion type: memory and executive function with AD pathologic changes and cortical μVBI, executive function with subcortical μVBI, and visuospatial construction with LBD. Thus, neuropathologic lesions of LBD and μVBI are associated with poorer cognitive performance over and above AD neuropathologic changes in subjects without dementia in this cohort. These findings underscore that cognitive impairment is a complex convergent trait that has important implications for clinical investigation and medical management of older adults.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Neuropathologic Correlates of Cognition in a Population-Based Sample

Cholerton

Larson

Baker

et al. 2013

JAD

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“…76 Focal brain lesions, typically affecting thalamic and/or midbrain structures, may also lead to the expression of palilalic behaviors. 34,60,62,[76][77][78][79][80][81][82][83][84][85] A family with extensive intracerebral calcification was reported to present palilalia, 86 and indeed patients with Fahr syndrome, an etiologically heterogeneous disorder, 87 will often present this clinical sign. Further, palilalia was reported as ictal, 88 autoimmune, 89 and drug-induced phenomenon (eg, with clozapine 90 or cefepime 91 ).…”

Section: Palilaliamentioning

confidence: 99%

The spectrum of involuntary vocalizations in humans: A video atlas

et al. 2019

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In clinical practice, involuntary vocalizing behaviors are typically associated with Tourette syndrome and other tic disorders. However, they may also be encountered throughout the entire tenor of neuropsychiatry, movement disorders, and neurodevelopmental syndromes. Importantly, involuntary vocalizing behaviors may often constitute a predominant clinical sign, and, therefore, their early recognition and appropriate classification are necessary to guide diagnosis and treatment. Clinical literature and video‐documented cases on the topic are surprisingly scarce. Here, we pooled data from 5 expert centers of movement disorders, with instructive video material to cover the entire range of involuntary vocalizations in humans. Medical literature was also reviewed to document the range of possible etiologies associated with the different types of vocalizing behaviors and to explore treatment options. We propose a phenomenological classification of involuntary vocalizations within different categorical domains, including (1) tics and tic‐like vocalizations, (2) vocalizations as part of stereotypies, (3) vocalizations as part of dystonia or chorea, (4) continuous vocalizing behaviors such as groaning or grunting, (5) pathological laughter and crying, (6) vocalizations resembling physiological reflexes, and (7) other vocalizations, for example, those associated with exaggerated startle responses, as part of epilepsy and sleep‐related phenomena. We provide comprehensive lists of their associated etiologies, including neurodevelopmental, neurodegenerative, neuroimmunological, and structural causes and clinical clues. We then expand on the pathophysiology of the different vocalizing behaviors and comment on available treatment options. Finally, we present an algorithmic approach that covers the wide range of involuntary vocalizations in humans, with the ultimate goal of improving diagnostic accuracy and guiding appropriate treatment. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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“…The neuro-linguistic diagnostic protocol used for the assessment of speech and language status [8] included MMSE [9], Boston Diagnostic Aphasia Examination (BDAE) [10], Boston Naming Test (BNT) [11] and phonemic and category fluency tests [12]. For the purposes of this research, we have designed a specific protocol for the assessment of the ability for recognition and naming of colors (ARNC) (verbal-verbal, visual-visual and visual-verbal tasks).…”

Section: Case Reportmentioning

confidence: 99%

Neurorehabilitation of alexia without agraphia - a case report

Tomić¹,

Nikolić²,

Punišić³

et al. 2018

Med pregl

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Introduction. Alexia without agraphia is an impairment of reading ability. Speech, auditory comprehension, repetition and writing are relatively intact. Due to a damage of the splenium of corpus callosum, alexia without agraphia is considered to be an interhemispheric disconnection syndrome. Case Report. We presented a 71-year-old male, with chronic hypertension, diabetes mellitus and dyslipidemia. The magnetic resonance imaging showed a lesion in the left medial temporal region, including the equilateral thalamus, posterior cingulate gyrus, splenium of corpus callosum, lingual occipital gyrus, and the tail of the hippocampus. Lacunar ischemia was found on the right side of cerebellum. The neuro-linguistic diagnostic protocol included the Mini Mental State Examination, Boston Diagnostic Aphasia Examination, Boston Naming Test and phonemic and category fluency tests. We have also designed a clinical protocol for color recognition assessment. The results showed a mild cognitive impairment related to the time and space orientation, delayed memory and reading. On the speech and language levels, a severe acquired alexia without agraphia was registered which was not associated with other language modalities. Conclusion. The neuro-linguistic tests and clinical techniques provide a rather reliable diagnostic criteria, which is the basis for neuro-rehabilitation. The rehabilitation protocol refers to training techniques: tactile-kinesthetic recognition of graphemes and application of various reading techniques, such as letter-by-letter reading, Multiple Oral Re-reading, melodic intonation therapy and oral reading technique in order to facilitate rehabilitation of reading. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 178027]

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Speech and language disorders secondary to diffuse subcortical vascular lesions: Neurolinguistic and acoustic analysis. A case report

Cited by 11 publications

References 20 publications

Neuropathologic Correlates of Cognition in a Population-Based Sample

Neuropathologic Correlates of Cognition in a Population-Based Sample

The spectrum of involuntary vocalizations in humans: A video atlas

Neurorehabilitation of alexia without agraphia - a case report

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