Empirical work has shown that maternal education is related to children’s language outcomes, especially in the societal language, among Spanish-English bilingual children growing up in the U.S. However, no study thus far has assessed the links between maternal cultural orientation and children’s speech sound production. This paper explores whether mothers’ orientation to American (acculturation) and Mexican culture (enculturation) and overall linear acculturation are related to children’s accuracy of production of consonants, of different sound classes, and of phonemes shared and unshared between languages in both English and Spanish at age 4;6 (4 years and 6 months). The results reveal a link between maternal acculturation and children’s segmental accuracy in English, but no relation was found between mothers’ enculturation and children’s speech sound production in Spanish. We interpreted the results in English as suggesting that more American-oriented mothers may have been using more English with their children, boosting their English production abilities and promoting English speech sound development. At the same time, we speculate that the results in Spanish were possibly due to the high and homogeneous levels of Mexican orientation among mothers, to language input differences attributable to distinct cultural practices, or to the status of Spanish as a minority language.