Speech and school performance in children with benign partial epilepsy with centro-temporal spikes (BCECTS)

Völkl-Kernstock, Sabine; Bauch-Prater, Sonja; Ponocny‐Seliger, Elisabeth; Feucht, Martha

doi:10.1016/j.seizure.2008.11.011

Cited by 83 publications

(84 citation statements)

References 47 publications

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“…Impairment of language development is one symptom of active epilepsy in children. Several case reports have described an association between nocturnal epileptiform EEG discharges and language impairment [1]. This is partly confirmed in some of the studies that investigated the effect of nocturnal epileptiform EEG discharges on neurocognitive function [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 72%

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Impaired language performance as a precursor or consequence of Rolandic epilepsy?

Overvliet

Aldenkamp

Klinkenberg

et al. 2011

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 72%

“…However, several studies have demonstrated cognitive impairment in children with Rolandic epilepsy [1,6,[13][14][15]. In particular language impairment may occur.…”

Section: Introductionmentioning

confidence: 99%

Impaired language performance as a precursor or consequence of Rolandic epilepsy?

Overvliet

Aldenkamp

Klinkenberg

et al. 2011

Journal of the Neurological Sciences

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“…Normal neurocognitive function and outcome was classically an integral feature of these syndromes. However, detailed neuropsychological examination may reveal mild cognitive dysfunction in several domains, and-in the setting of additional neuropsychological testing in recent years-there is an increased prevalence of language, learning, and behavioral disorders (Croona et al, 1999;Fejerman, 2009;Germano et al, 2005;Gulgonen et al, 2000;Metz-Lutz and Filippini, 2006;Panayiotopoulos et al, 2008;Pinton et al, 2006;Sart et al, 2006;Vinayan et al, 2005;Völkl-Kernstock et al, 2009). Evolution of atypical BECTS into BOEC illustrates this spectrum (Caraballo et al, 2008).…”

Section: Bects and Boecmentioning

confidence: 99%

Continuous Spike and Waves During Sleep and Electrical Status Epilepticus in Sleep

Loddenkemper

Fernández²,

Peters³

2011

Journal of Clinical Neurophysiology

109

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Continuous spike and waves during sleep is an age-related epileptic encephalopathy that presents with neurocognitive regression, seizures, and an EEG pattern of electrical status epilepticus during sleep. Patients usually present around 5 years of age with infrequent nocturnal unilateral motor seizures that progress within 1 to 2 years to a severe epileptic encephalopathy with frequent seizures of different types, marked neurocognitive regression, and an almost continuous spike-wave EEG pattern during slow-wave sleep. The pathophysiology of continuous spike and waves during sleep is not completely understood, but the corticothalamic neuronal network involved in physiologic oscillating patterns of sleep is thought to be switched into a pathologic discharging mode. Early developmental injury and/or genetic predisposition may play a role in the potentiation of age-related hyperexcitability in the immature brain. A better understanding of the mechanisms leading to electrical status epilepticus during sleep may provide additional therapeutic targets that can improve the outcome of seizures, EEG pattern, and cognitive development in patients with continuous spike and waves during sleep.

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“…Because of the increasing awareness of significant comorbidities in RE, its classification as benign is under debate (Hughes, 2010;Nicolai et al, 2006;Vinayan et al, 2005;Völkl-Kernstock et al, 2009;Weglage et al, 1997). In the current study, we report widespread cortical abnormalities in language areas in children with RE who were selected based on EEG criteria and seizure semiology and not on language performance.…”

Section: Clinical Outlookmentioning

confidence: 99%

“…Although the seizure semiology of RE is relatively mild (Lerman and Kivity, 1975;Loiseau et al, 1992), recent evidence suggests serious comorbidities in selected cases and has put the assumed purely benign nature of RE under debate (Nicolai et al, 2006;Vinayan et al, 2005;Völkl-Kernstock et al, 2009;Weglage et al, 1997). An often reported comorbidity of RE is language impairment (Monjauze et al, 2005;Northcott et al, 2007;Overvliet et al, 2010;Papavasiliou et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Early onset of cortical thinning in children with Rolandic epilepsy

Overvliet

Besseling

Jansen

et al. 2013

Journal of the Neurological Sciences

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Introduction: Rolandic epilepsy, a childhood epilepsy associated with language impairments, was investigated for language-related cortical abnormalities. Methods: Twenty-four children with rolandic epilepsy and 24 controls (age 8-14 years) were recruited and underwent the Clinical Evaluation of Language Fundamentals test. Structural MRI was performed at 3 T (voxel size 1 × 1 × 1 mm 3 ) for fully automated quantitative assessment of cortical thickness. Regression analysis was used to test for differences between patients and controls and to assess the effect of age and language indices on cortical thickness. Results: For patients the core language score (mean ± SD: 92 ± 18) was lower than for controls (106 ± 11, p = 0.0026) and below the norm of 100 ± 15 (p = 0.047). Patients showed specific impairments in receptive language index (87 ± 19, p = 0.002) and language content index (87 ± 18, p = 0.0016). Cortical thickness was reduced in patients (p b 0.05, multiple-comparisons corrected) in left perisylvian regions. Furthermore, extensive cortical thinning with age was found in predominantly left-lateralized frontal, centro-parietal and temporal regions. No associations were found between cortical thickness and language indices in the regions of aberrant cortex. Conclusion: The cortical abnormalities described represent subtle but significant pathomorphology in this critical phase of brain development (8-14 years) and suggest that rolandic epilepsy should not be considered merely a...

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Speech and school performance in children with benign partial epilepsy with centro-temporal spikes (BCECTS)

Abstract: Both deficits of speech-related abilities (in both expressive and receptive vocabulary) and behavioral disturbances can be detected in children with typical BCECTS, but are no longer apparent after remission of the seizure disorder.

Cited by 83 publications

References 47 publications

Impaired language performance as a precursor or consequence of Rolandic epilepsy?

Impaired language performance as a precursor or consequence of Rolandic epilepsy?

Continuous Spike and Waves During Sleep and Electrical Status Epilepticus in Sleep

Early onset of cortical thinning in children with Rolandic epilepsy

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