Speech Perception Results for Children Implanted with the Clarion® Cochlear Implant at the Medical University of Hannover

Illg, Angelika; S, von der Haar-Heise; Je, Goldring; Lesinski‐Schiedat, Anke; Battmer, R. D.; Lenarz, Thomas

doi:10.1177/00034894991080s419

Cited by 17 publications

(9 citation statements)

References 4 publications

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“…The implant operates by directly electrically stimulating the auditory nerve, bypassing damaged or missing sensory receptor cells. This device now provides significant speech understanding, with a score for everyday sentence understanding of about 80% without lip reading in the majority of patients implanted (so far more than 40,000 worldwide) (1)(2)(3). However, the cochlear prosthesis depends on remaining excitable auditory nerve fibers, and their loss severely compromises the effectiveness of the implant and the hearing benefits it provides.…”

mentioning

confidence: 99%

Neurotrophic factor intervention restores auditory function in deafened animals

Shinohara

Bredberg

Ulfendahl

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

200

176

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A primary cause of deafness is damage of receptor cells in the inner ear. Clinically, it has been demonstrated that effective functionality can be provided by electrical stimulation of the auditory nerve, thus bypassing damaged receptor cells. However, subsequent to sensory cell loss there is a secondary degeneration of the afferent nerve fibers, resulting in reduced effectiveness of such cochlear prostheses. The effects of neurotrophic factors were tested in a guinea pig cochlear prosthesis model. After chemical deafening to mimic the clinical situation, the neurotrophic factors brain-derived neurotrophic factor and an analogue of ciliary neurotrophic factor were infused directly into the cochlea of the inner ear for 26 days by using an osmotic pump system. An electrode introduced into the cochlea was used to elicit auditory responses just as in patients implanted with cochlear prostheses. Intervention with brainderived neurotrophic factor and the ciliary neurotrophic factor analogue not only increased the survival of auditory spiral ganglion neurons, but significantly enhanced the functional responsiveness of the auditory system as measured by using electrically evoked auditory brainstem responses. This demonstration that neurotrophin intervention enhances threshold sensitivity within the auditory system will have great clinical importance for the treatment of deaf patients with cochlear prostheses. The findings have direct implications for the enhancement of responsiveness in deafferented peripheral nerves. Hearing impairment is the most frequent disability of people in industrialized countries, affecting more than one in seven individuals. Most hearing loss is caused by destruction of the sensory cells within the cochlea of the inner ear. In mammals, the auditory cells do not regenerate, nor are there currently effective interventions for their repair. Moreover, in the auditory system, as in other afferent systems, degeneration of the auditory nerve occurs secondary to the loss of the inner ear sensory cells (hair cells), thus aggravating the functional impairment. In the severely and profoundly deaf, the cochlear implant (prosthesis) has been shown to provide an effective habilitative intervention. The cochlear prosthesis consists of one or more electrodes inserted into the fluid space of the inner ear. The implant operates by directly electrically stimulating the auditory nerve, bypassing damaged or missing sensory receptor cells. This device now provides significant speech understanding, with a score for everyday sentence understanding of about 80% without lip reading in the majority of patients implanted (so far more than 40,000 worldwide) (1-3). However, the cochlear prosthesis depends on remaining excitable auditory nerve fibers, and their loss severely compromises the effectiveness of the implant and the hearing benefits it provides. Studies show a clear relationship between the total number of viable auditory neurons available for stimulation and the performance of subjects receiving cochlear implant...

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mentioning

confidence: 99%

Neurotrophic factor intervention restores auditory function in deafened animals

Shinohara

Bredberg

Ulfendahl

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

200

176

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“…Eine möglichst frühe Erkennung von Hörstörungen, beispielsweise durch das Neugeborenen-Screening, und die baldige Versorgung durch ein "Cochlear Implant" (CI) ermöglichen es dem Kind, in Verbindung mit einer intensiven Rehabilitation, eine nahezu normale Sprachentwicklung zu erreichen und eine Regelschule zu besuchen [6].…”

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“…Diese Defizite sind durch den Einsatz eines CI reversibel [6,18,19]. Viele Studien bestätigen, dass eine frühere Implantation schnellere und bessere Sprachkompetenz und -produktion bedingt, sodass viele Autoren eine mög-lichst frühzeitige Implantation befür-worten [1,4,11,13,16,17].…”

Section: Ergebnisseunclassified

91 dB Hörverlust - die Schwelle zum "Cochlear Implant"?

Walch

Moser

Anderhuber

et al. 2000

HNO

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“…Um die Ergebnisse des Echosensors mit denen des konventionellen TEOAE-Meßgeräts ILO88 zu vergleichen, wurden OAE-Messungen an 111 Neugeborenen von audiologisch geschulten Personen durchgeführt.Im Rahmen dieser Pilotstudie wurden Reliabilität und Validität der Messungen im Vergleich zum Goldstandard der Hirnstammaudiometrie bestimmt.Es zeigte sich eine sehr hohe Übereinstimmung (Sensitivität 100%, Spezifität 93,3%) zwischen den Ergebnissen Für eine suffiziente Behandlung angeborener kindlicher Schwerhörigkeiten ist die rechtzeitige Diagnose die entscheidende Voraussetzung. Je früher eine Schwerhörigkeit erkannt wird, desto größer ist die Chance für das Kind, mit rechtzeitigen und adäquaten, bereits heute verfügbaren Therapie-und Rehabilitationsmaßnahmen eine annähernd normale Sprachentwicklung zu erreichen [9,16]. Hörvermögen und Sprachentwicklung sind untrennbar miteinander verbunden.…”

Section: Zusammenfassungunclassified

Neugeborenenhörscreening mit dem automatisierten Meßgerät Echosensor für otoakustische Emissionen

Reuter

Bördgen

Dressler

et al. 1998

HNO

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Following the recommendations of the United States National Institutes of Health Consensus Conference in 1993, otoacoustic emissions (OAE) are now used internationally for hearing screening. The use of recording systems as well as the interpretation of results requires specially trained personnel although measurements are easier to perform than other recording methods available. To date, no objective method for general hearing screening, has been introduced in Germany, for neonates or children at risk, even though it would be desirable to detect and rehabilitate children with congenital hearing loss as early as possible (incidence, 1-6 per 1000). The Echosensor provides the means for carrying out OAE recordings within a short period of time and includes an automatic evaluation of results. Recordings can also be made by trained personnel. As a comparison test, audiologically trained staff recorded otoacoustic emissions in 111 new-born children in order to compare the results of the Echosensor with the results of a conventional OAE measurements device (the ILO88). The aim of this pilot study was to determine the reliability and validity of the recordings in comparison with available standards in brainstem audiometry. Our study showed that the results of the Echosensor corresponded well with the ILO88 results. Consequently, an OAE measuring method is now available is also provides high sensitivity and specificity and is easy to use. Our findings show that the Echosensor can meet the demands of systematic hearing screening in Germany.

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Speech Perception Results for Children Implanted with the Clarion® Cochlear Implant at the Medical University of Hannover

Cited by 17 publications

References 4 publications

Neurotrophic factor intervention restores auditory function in deafened animals

Neurotrophic factor intervention restores auditory function in deafened animals

91 dB Hörverlust - die Schwelle zum "Cochlear Implant"?

Neugeborenenhörscreening mit dem automatisierten Meßgerät Echosensor für otoakustische Emissionen

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