Speech prognosis and need of pharyngeal flap for non syndromic vs syndromic Pierre Robin Sequence

Roessingh, Anthony de Buys; Herzog, Georges; Cherpillod, Jacques; Trichet-Zbinden, Chantal; Hohlfeld, Judith

doi:10.1016/j.jpedsurg.2007.09.050

Cited by 34 publications

(20 citation statements)

References 20 publications

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“…Our study agrees with Khosla et al and we found no difference between the PRS patients and the CPO patients who developed VPI requiring surgical correction, however their data only compared speech outcomes in patients with soft palate clefts only, repaired with a Z-plasty technique [14]. A study by de Buys et al comparing speech outcomes between syndromic and non-syndromic PRS patients showed no differences in the need for surgical intervention for VPI [15]. Furthermore, the rate of surgical correction of VPI in the syndromic PRS patients was 23% compared to 36% of the non-syndromic patients, with an average rate of 31% for all patients, which is higher than what we found but less than that found by Witt et al [6,15].…”

Section: Discussionsupporting

confidence: 91%

“…In our PRS patients we did not identify higher rates of VPI after palate repair compared to cleft palate only patients, which contradicts the findings of Witt et al [15]. Post-palatoplasty VPI occurs in up to one fifth of non-syndromic children who have had their cleft palate repaired [8].…”

Section: Discussioncontrasting

confidence: 84%

“…Although Witt et al found that PRS patients have a higher degree of VPI after palate repair, other studies suggest that the occurrence of VPI in PRS patients is no different than patients with cleft palate alone [14,15]. Based on our experience we hypothesize that PRS children are no more likely to require secondary surgery to correct velopharyngeal function than non-syndromic cleft palate only (CPO) patients.…”

Section: Introductionmentioning

confidence: 59%

See 2 more Smart Citations

The occurrence of velopharyngeal insufficiency in Pierre Robin Sequence patients

Goudy¹,

Ingraham²,

Canady³

2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 59%

See 1 more Smart Citation

The occurrence of velopharyngeal insufficiency in Pierre Robin Sequence patients

Goudy¹,

Ingraham²,

Canady³

2011

International Journal of Pediatric Otorhinolaryngology

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“…PRS includes a micrognatia or underdevelopment of the mandible which causes glossoptosis, a relatively enlarged tongue relative to the space within the oral cavity. The glossoptosis interferes with the fusion of the palatal shelves during the early embryonic period (4 -12 weeks) resulting in a sub -total cleft of the secondary palate [12][13][14][15][16][17][18][19][20][21][22].…”

Section: Cleft Palate and Submucous Cleft Palatementioning

confidence: 99%

“…However, in several cases, an early mandibular distraction is indicated. All patients with syndromic PRS are present with VPI [21][22][23]27]. …”

Section: Syndromic Pierre -Robin Sequencementioning

confidence: 99%

Diagnosis and Management of Velopharyngeal Insufficiency Associated with Chromosomal Syndromes

Ysunza

Craniofacial²,

Lozon³

2013

Clon Transgen

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All congenital structural defects in the body are the result of an error in morphogenesis. Morphogenesis takes place around 25 to 29 days of intrauterine life. Chromosomal syndromes involve a phenotypically significant structural and/or numerical chromosomal abnormality.An insufficient function of the velopharyngeal sphincter induces excessive nasal resonance during speech. This abnormal resonance is called hypernasality. A deficient seal of the velopharyngeal sphincter creates an airflow leaking into the rhinopharynx, resulting in abnormal air turbulence through the nasal cavities which can be easily perceived and is called nasal emission. Hypernasality and nasal emission are the clinical signs of velopharyngeal insufficiency (VPI). In other words, VPI is the velopharyngeal inability to create an efficient seal during speech.Most chromosomal syndromes cause VPI as a consequence of a cleft palate. However, when patients with a chromosomal abnormality and VPI are being clinically assessed, it is essential to keep in mind that an apparently and morphologically intact uvula and velum do not rule out the possibility of a sub mucous cleft palate.Several chromosomal syndromes can be associated with VPI, including: 22q11.2 deletion syndrome (22q11.2DS) or velocardiofacial syndrome among other names, Opitz G/BBB syndrome (OS), Kabuki syndrome (KS) and Jacobsen syndrome (JS). Pierre -Robin sequence (PRS) can be associated with some chromosomal syndromes. In these cases, PRS is referred as syndromic PRS.In this paper, the diagnosis and management of VPI in the most common chromosomal syndromes is discussed.

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Facial Cleft and Pierre Robin Sequence

et al. 2019

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Speech prognosis and need of pharyngeal flap for non syndromic vs syndromic Pierre Robin Sequence

Cited by 34 publications

References 20 publications

The occurrence of velopharyngeal insufficiency in Pierre Robin Sequence patients

The occurrence of velopharyngeal insufficiency in Pierre Robin Sequence patients

Diagnosis and Management of Velopharyngeal Insufficiency Associated with Chromosomal Syndromes

Facial Cleft and Pierre Robin Sequence

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