Speed of sound ultrasound: a pilot study on a novel technique to identify sarcopenia in seniors

Sanabria, Sergio J.; Martini, Katharina; Freystätter, Gregor; Ruby, Lisa; Göksel, Orçun; Frauenfelder, Thomas; Rominger, Marga B.

doi:10.1007/s00330-018-5742-2

Cited by 46 publications

(67 citation statements)

References 53 publications

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“…A pilot study by Sanabria et al evaluated SoS in calf muscles bilaterally in 11 young healthy women and 10 elderly women using conventional ultrasound equipment and a Plexiglas reflector at the opposite end of the extremity. 52 The SoS technique and a variation, called ΔSoS, showed significant differences between groups; the measurement technique was rapidly effected and well tolerated. Moreover, SoS strongly correlated with muscle strength and muscle performance tests (handgrip strength and Tegner score test).…”

Section: Speed Of Sound Ultrasoundmentioning

confidence: 96%

“…Ultrasound waves hit the panel and return to the transducer, with different types of tissue yielding different SoS. 52,53 SoS US is valuable for revealing breast tissue composition. Evidence indicates that SoS US values related to breast tissue correlate with American College of Radiology mammographic breast density categories.…”

Section: Speed Of Sound Ultrasoundmentioning

confidence: 99%

“…Muscle and adipose tissues have different SoS times (1440 m/s for adipose tissue; 1585 m/s for muscle). 52 Therefore, there may be benefits of using SoS ultrasound for the evaluation of muscular and adipose tissue percentage within the skeletal muscles and for assessing muscle quality.…”

Section: Speed Of Sound Ultrasoundmentioning

confidence: 99%

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Future Ultrasound Biomarkers for Sarcopenia: Elastography, Contrast-Enhanced Ultrasound, and Speed of Sound Ultrasound Imaging

Ivanoski

Nikodinovska

2020

Semin Musculoskelet Radiol

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Sarcopenia is the advanced and generalized loss of muscle mass and strength among the elderly population and is a cause of adverse outcomes. Methods used for the diagnosis of sarcopenia are either unavailable or expensive in everyday clinical settings. Ultrasound presents an inexpensive, convenient, and available method that offers advantages for the evaluation of skeletal muscle. Muscle quality will probably be the most important factor in defining sarcopenia in the future. Different features of muscle quality, including muscle elasticity, microcirculation and muscle perfusion during rest and physical activity, and the content of intramuscular adipose tissue can be measured using emerging and promising ultrasound techniques such as elastography, contrast-enhanced imaging, and speed of sound ultrasound technology. This article reviews the recent evidence on the use of ultrasound techniques in the assessment of muscle quality and the possibilities for the future evaluation of sarcopenia.

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Section: Speed Of Sound Ultrasoundmentioning

confidence: 96%

Section: Speed Of Sound Ultrasoundmentioning

confidence: 99%

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Future Ultrasound Biomarkers for Sarcopenia: Elastography, Contrast-Enhanced Ultrasound, and Speed of Sound Ultrasound Imaging

Ivanoski

Nikodinovska

2020

Semin Musculoskelet Radiol

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“…99 A group of authors recently proposed a quantitative method based on speed of sound using a portable US system coupled with a plastic reflector for the assessment of calf muscles. 100 Speed of sound is lower in fat than in muscular tissue, and this difference can then be used to quantify muscle and fat content. Such an approach was superior to conventional thickness and echo intensity parameters.…”

Section: Quantitative Ultrasound In Osteosarcopeniamentioning

confidence: 99%

Quantitative Musculoskeletal Ultrasound

Gitto

Messina

Vitale

et al. 2020

Semin Musculoskelet Radiol

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Ultrasound (US) imaging plays a crucial role in the assessment of musculoskeletal (MSK) disorders. Several quantitative tools are offered by US systems and add information to conventional US imaging. This article reviews the quantitative US imaging tools currently available in MSK radiology, specifically focusing on the evaluation of elasticity with shear-wave elastography, perfusion with contrast-enhanced US and noncontrast superb microvascular imaging, and bone and muscle mass with quantitative US methods. Some of them are well established and already of clinical value, such as elasticity and contrast-enhanced perfusion assessment in muscles and tendons. MSK radiologists should be aware of the potential of quantitative US tools and take advantage of their use in everyday practice, both for clinical and research purposes.

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“…34 External reflectors in combination with hand-held US probes have been used to measure SoS (external reflector-based method). 35,36 Sanabria et al 34 have shown the potential of tissue reflections and scattering (speckles) to serve as internal reflector and timing references, which leads to even easier measurement operability for SoS imaging by hand-held probes.…”

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confidence: 99%

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections

et al. 2019

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The aim of this study was to differentiate malignant and benign solid breast lesions with a novel ultrasound (US) technique, which measures speed of sound (SoS) using standard US transducers and intrinsic tissue reflections and scattering (speckles) as internal reference. MATERIALS AND METHODS This prospective, institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective comparison study was performed with prior written informed consent from 20 women. Ten women with histological proven breast cancer and 10 with fibroadenoma were measured. A conventional US system with a linear probe was used for SoS-US (SonixTouch; Ultrasonix, Richmond, British Columbia, Canada). Tissue speckle reflections served as a timing reference for the US signals transmitted through the breasts. Relative phase inconsistencies were detected using plane wave measurements from different angular directions, and SoS images with 0.5-mm resolution were generated using a spatial domain reconstruction algorithm. The SoS of tumors were compared with the breast density of a larger cohort of 106 healthy women. RESULTS Breast lesions show focal increments ΔSoS (meters per second) with respect to the tissue background. Peak ΔSoS values were evaluated. Breast carcinoma showed significantly higher ΔSoS than fibroadenomas ([INCREMENT]SoS > 41.64 m/s: sensitivity, 90%; specificity, 80%; area under curve, 0.910) and healthy breast tissue of different densities (area under curve, 0.938; sensitivity, 90%; specificity, 96.5%). The lesion localization in SoS-US images was consistent with B-mode imaging and repeated SoS-US measurements were reproducible. CONCLUSIONS Using SoS-US, based on conventional US and tissue speckles as timing reference, breast carcinoma showed significantly higher SoS values than fibroadenoma and healthy breast tissue of different densities. The SoS presents a promising technique for differentiating solid breast lesions.

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Speed of sound ultrasound: a pilot study on a novel technique to identify sarcopenia in seniors

Cited by 46 publications

References 53 publications

Future Ultrasound Biomarkers for Sarcopenia: Elastography, Contrast-Enhanced Ultrasound, and Speed of Sound Ultrasound Imaging

Future Ultrasound Biomarkers for Sarcopenia: Elastography, Contrast-Enhanced Ultrasound, and Speed of Sound Ultrasound Imaging

Quantitative Musculoskeletal Ultrasound

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections

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