Speed of tooth movement is related to stress and IL-1 gene polymorphisms

Iwasaki, Laura R.; Gibson, Colin; Crouch, Larry D.; Marx, David B.; Pandey, Janardan P.; Nickel, Jeffrey C.

doi:10.1016/j.ajodo.2006.04.022

Cited by 56 publications

(69 citation statements)

References 29 publications

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“…Among these studies, further analysis of the titles, abstracts, and fulltexts revealed that 25 were relevant for the present study. A summary of papers that were excluded is presented in Figure 1 (exhibiting the orthodontic mechanics, GCF sampling methods, and cytokine measurements) [1][2][3][4][5][6][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

“…Among the 25 studies, the most commonly studied cytokines were IL-1β (n=12), PGE 2 (n=5), TNF-α (n=7), and IL-6 (n=5) (Figure 1). Four studies [23,30,32,42] had to be excluded from quantitative data synthesis because of insufficient relevant data or fewer than three observation time-points (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…With regard to the speed of tooth movement, Iwasaki et al [23,30,42] observed positive correlation with the IL-1β: IL-1 receptor antagonist (IL-1) ratio.…”

Section: Discussionmentioning

confidence: 99%

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Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: This paper aimed to analyze studies in the literature addressing the role of cytokines in the gingival crevicular fluid (GCF) in the orthodontic treatment. METHODS: Several databases were surveyed using both MESH terms and free terms. Additional studies were obtained by reference tracking. This review was registered in PROSPERO, and the procedures foreseen by its statement were followed. Data were obtained from the included studies addressing the orthodontic mechanics, GCF sampling/handling methods, and cytokine measurements. Clinical studies written in English were browsed. Papers were selected by one reviewer and checked by a second investigator. RESULTS: A total of 115 articles were identified, among which 25 were selected for detailed analysis. Common drawbacks consisted mainly of inadequacies in the study design (e.g. short duration and small number of study subjects). The most consistent result was a peak of cytokine levels at 1 d. Associations were observed between prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) and pain, velocity of tooth movement, and treatment mechanics. Interleukin-1b and PGE2 showed different patterns of up-regulation, with IL-1β being more responsive to mechanical stress and PGE2 more responsive to synergistic regulation of IL-1β and mechanical force. The results support the use of light continuous forces for orthodontic treatment. CONCLUSION: There was a tendency of maintenance of relatively high IL-1β levels for longer periods with the use of light continuous forces, which might decrease the frequency of activation. These outcomes provide evidence at the cellular level for the utilization of light continuous forces.Key words: Systematic review; Orthodontics, corrective; Gingival Crevicular Fluid (GCF); Interleukin; T Cells.Papel das citocinas presentes no fluido crevicular durante o tratamento ortodôntico: uma revisão sistemática REsUMO OBJETIVO: Este artigo teve como objetivo analisar estudos na literatura abordando o papel das citocinas no Líquido do Sulco Gengival no tratamento ortodôntico. MéTODOS: Várias bases de dados foram pesquisadas usando termos MESH e termos livres. Estudos adicionais foram obtidos por rastreamento de referência. Esta revisão foi registrada no PROSPERO, e os procedimentos previstos por sua declaração foram seguidos. Os dados foram obtidos dos estudos incluídos sobre a mecânica ortodôntica, métodos de amostragem / manuseio de Líquido do Sulco Gengival e medições de citoquinas. Estudos clínicos escritos em inglês foram pesquisados. Os trabalhos foram selecionados por um revisor e verificados por um segundo investigador. RESULTADOS: Foram identificados 115 artigos, dentre os quais 25 foram selecionados para análise detalhada. As desvantagens comuns consistiram principalmente em insuficiências no design do estudo (por exemplo, curta duração e pequeno número de sujeitos do estudo). O resultado mais consistente foi um pico de níveis de citocinas a 1 d. Foram observadas associações entre prostaglandina E2 (PGE2) e interleucina-1β (IL-1β) ...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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“…For instance, patients homozygous for allele 1 of IL-1β (diminished levels of IL-β) had an accentuated ERR response attributed to a slow initiation of tooth movement (Al-Qawasmi et al, 2003a). However, in a recent clinical study, patients homozygous for allele 1of IL-1β demonstrated increased rates of sustained tooth movement compared to other patients (Iwasaki et al, 2006). This inconsistency may be biologically valid and related to timing of the study (the initial presence of necrotic tissue,) or it may reflect an uncontrolled mechanical environment in the clinical setting.…”

Section: Discussionmentioning

confidence: 99%

“…Histological results can be puzzling (Verna et al, 1999) if the sectioning plane orientations are not determined according to specific stress (loading) patterns. This is sometimes neglected in clinical and basic science studies in which biological responses are linked to orthodontic loads and/or "stresses" that are improperly characterized (Iwasaki et al, 2006). Although there are some attempts for clarification, e.g., parametric analyses and partial descriptions, knowledge gaps abound at virtually all steps of the cascade shown in Figure 11.…”

Section: The Three-dimensional Mechanical Environment Of Orthodonticmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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Genetic influences on orthodontic tooth movement

Zeichner‐David¹

2015

Biological Mechanisms of Tooth Movement

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Speed of tooth movement is related to stress and IL-1 gene polymorphisms

Cited by 56 publications

References 29 publications

Cytokines in crevicular fluid and orthodontic force: a systematic review

Cytokines in crevicular fluid and orthodontic force: a systematic review

Orthodontic mechanotransduction and the role of the P2X7 receptor

Genetic influences on orthodontic tooth movement

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