Sperm Dynamics in Tubular Confinement

Magdanz, Veronika; Koch, Britta; Sánchez, Samuel; Schmidt, Oliver G.

doi:10.1002/smll.201401881

Cited by 24 publications

(19 citation statements)

References 34 publications

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“…An external magnetic field is applied to control the orientation and motion trajectory, as expressed by the red arrows ( Figure IB,C) [60]. More recently, transparent microtubes of diameters 10-45 mm were fabricated by the same research group using rolled-up transparent silicon oxide/dioxide nanomembranes and were utilized to study sperm dynamics in tubular confinements [61]. The effects of tube diameter on the velocity, directionality, and linearity of sperm were investigated.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Microfluidics for sperm research

Knowlton

Sadasivam

Tasoğlu

2015

Trends in Biotechnology

124

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Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Microfluidics for sperm research

Knowlton

Sadasivam

Tasoğlu

2015

Trends in Biotechnology

124

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“…A first means to orientate themselves in the comparatively vast environment inside the uterus -after passing the hostile, low-pH vagina and cervix region by ejaculation and sheer numbers -is their tendency to swim preferably along walls, that is, endothelium (Fauci and McDonald 1995, Denissenko et al 2012, Rode et al 2018. This behavior can be considered as a form of thigmotaxis, that is, the ability to follow a touch stimulus (Magdanz et al 2015a). Inside the uterus, peristaltic pumping by muscle contractions of the epithelial surroundings seems to be the major factor to transport sperm, as it has been reported that sperm cells can be found inside the fallopian tubes only seconds after ejaculation, which would otherwise not be possible simply by flagellar swimming with a speed of several tens of micrometers per second (Brannigan and Lipshultz 2008).…”

Section: Sperm Taxis and Cooperative Actionmentioning

confidence: 99%

Sperm-hybrid micromotors: on-board assistance for nature’s bustling swimmers

2020

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Sperm cells that cannot swim and orient properly compromise male fertility. Such defects are responsible for male infertility regardless of the actual quality of the most important content, the sperm’s DNA. Synthetic micromotors are engineered devices that are able to swim in (body) fluids and microscopic environments, similar to flagellated cells like sperm. Coupled together, a sperm-hybrid micromotor embodies the concept of bringing the sperm cell together with artificial components that assist or replace defective functions of the cell, helping it to pursue its goal without interfering with its health, enabling the process of assisted fertilization and further embryo development all inside the body. Non-invasive, remote-controlled in vivo applicability is the key quality of such hybrid microdevices. Assisted reproduction with the help of micromotors is in the focus of this review, although other biomedical applications that arise from the powerful combination of sperm cell and synthetic enhancement are also discussed and summarized. Details are provided about different fabrication processes and cell-material coupling strategies, and the way from proof-of-concept studies to in vivo experiments in animals is outlined.

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“…1(b, d-f)). 7 The influence of tube diameter on the velocity, directionality, and linearity of spermatozoa was investigated. 6 In another recent publication, Magdanz et al fabricated an on-chip system that mimics tubular micro-environments for the study of spermatozoa motion in confinement ( Fig.…”

Section: Transparent Biocompatible Microtubes For Cell Studiesmentioning

confidence: 99%

Lab-in-a-tube systems as ultra-compact devices

Sánchez

2015

Lab Chip

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In this Focus article, I will give an overview on the current and future interests of our multidisciplinary research group. One of our main interests is to develop highly integrated on-chip components towards ultra-compact devices for biosensing technologies (lab-in-a-tube). Our other activities are focused in developing self-powered devices that can generate either motion of a fluid or autonomous propulsion. We are particularly interested in three-dimensional (3D) nanofabrication technologies and stimuli responsive soft materials.

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Sperm Dynamics in Tubular Confinement

Cited by 24 publications

References 34 publications

Microfluidics for sperm research

Microfluidics for sperm research

Sperm-hybrid micromotors: on-board assistance for nature’s bustling swimmers

Lab-in-a-tube systems as ultra-compact devices

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