Sperm Oxidative Stress and the Effect of an Oral Vitamin E and Selenium Supplement on Semen Quality in Infertile Men

Keskes, Leila; Feki-Chakroun, N.; Rebaï, Tarek; Sahnoun, Zouheir; Ghozzi, H.; Hammami, S.; Zghal, K.; Fki, H.; Damak, J.; Bahloul, A.

doi:10.1080/01485010390129269

Cited by 302 publications

(151 citation statements)

References 45 publications

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“…However the results of antioxidant therapy alone or in combination are controversial. For example, some studies have shown that vitamin C, vitamin E, zinc, folic acid, and selenium alone or in combination could improve sperm parameters, especially sperm motility and sperm DNA integrity (36)(37)(38)(39). In contrast, several reports refute the effects of these antioxidants on sperm parameters (40,41).…”

Section: Discussionmentioning

confidence: 86%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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Background: Oxidative stress is the result of an imbalance between the production and scavenging of reactive oxygen species (ROS). Recently, oxidative stress has been introduced as a major cause of male infertility. Objectives: The aim of the present study was to determine the correlation between total antioxidant capacity (TAC) and malondialdehyde (MDA) as markers of oxidative stress in relation to idiopathic male infertility and sperm parameters. Patients and Methods: This case control study was conducted using 35 men with idiopathic infertility and 34 men with proven fertility. Seminal plasma TAC and MDA were measured by ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods, respectively. Results: Seminal TAC levels were significantly lower and seminal MDA levels were significantly higher in men with idiopathic infertility than in fertile men (P < 0.0001 and P = 0.004, respectively). A positive correlation was shown between sperm motility, sperm morphology, and TAC levels in men with idiopathic infertility (P = 0.002 and P = 0.002, respectively). In addition, there was a correlation between sperm motility and TAC levels in fertile men (P = 0.005). There was no correlation between sperm count and TAC levels in either men with idiopathic infertility or in fertile men. Negative correlations were observed between MDA levels and sperm motility, morphology, and sperm count only in men with idiopathic infertility (P = 0.003, P = 0.001, and P = 0.006, respectively). Conclusions: Our results show that oxidative stress could play an important role in male infertility as well as in sperm motility and sperm morphology.

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Section: Discussionmentioning

confidence: 86%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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“…As already described, the trials conducted by Keskes-Ammar et al 43 in 2003 and by Safarinejad and Safarinejad 60 in 2009 used a combination therapy-selenium and vitamin E in the former and selenium and NAC in the latter-which led to increased motility in both studies and to an improvement in sperm count and morphology in the latter.…”

Section: Seleniummentioning

confidence: 90%

“…Only four of these studies [28][29][30][31] found little or no effect on semen parameters, whereas beneficial effects were reported in the remaining 18 studies. 8,19,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] In vitro studies. Two studies by Aitken et al 8,32 on the effects of vitamin E showed that 10 mmol l 21 suppressed lipid peroxidation, leading to preserved motility in vitro, with a dose-dependent effect.…”

Section: Vitamin Ementioning

confidence: 99%

The role of antioxidant therapy in the treatment of male infertility: an overview

Lombardo¹,

Sansone²,

Romanelli³

et al. 2011

Asian J Androl

100

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In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.

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“…Los antioxidantes se han utilizado en tratamientos in vivo e in vitro debido a su capacidad protectora (27)(28). Al incubar semen con una suspensión de neutrófilos activados, se crea un ambiente de estrés oxidativo, el cual lleva a la disminución de la movilidad progresiva, pero ésta se recupera al adicionar ciertos antioxidantes como la hipotaurina y la N-acetilcisteína, pero no al adicionar vitamina E (27).…”

Section: Discussionunclassified

“…Al incubar semen con una suspensión de neutrófilos activados, se crea un ambiente de estrés oxidativo, el cual lleva a la disminución de la movilidad progresiva, pero ésta se recupera al adicionar ciertos antioxidantes como la hipotaurina y la N-acetilcisteína, pero no al adicionar vitamina E (27). In vivo, se ha evaluado la capacidad de diferentes antioxidantes para proteger el espermatozoide humano (28); un estudio en el cual se realizó un tratamiento oral con vitamina E y un suplemento de selenio durante tres meses, mostró mejoría notoria en la movilidad y una disminución significativa en la concentración de malondialdehído (28).…”

Section: Discussionunclassified

Evaluación de parámetros seminales no convencionales en individuos cuyas parejas presentan muerte embrionaria temprana recurrente: en busca de un valor de referencia

et al. 2011

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Introducción. En estudios previos se relacionaron las alteraciones en los parámetros espermáticos no convencionales con la presencia de muerte embrionaria temprana recurrente de la pareja; debido a esto, se planteó la necesidad de establecer un valor de referencia de utilidad clínica para el manejo de estos pacientes. Objetivo. Evaluar los parámetros seminales convencionales y las pruebas funcionales de lipoperoxidación de las membranas espermáticas, capacidad antioxidante del plasma seminal e integridad de la cromatina espermática, en individuos cuyas parejas presentan muerte embrionaria temprana recurrente, con el fin de obtener un valor de referencia y poder identificar aquellos individuos en quienes la disminución de la fertilidad se pueda demostrar con estas pruebas. Materiales y métodos. Se evaluaron los parámetros espermáticos convencionales y no convencionales de 47 muestras de semen, de las cuales, 36 pertenecían al grupo de individuos con disminución de la fertilidad por historia de muerte embrionaria temprana recurrente en sus parejas, y 11 muestras de individuos sanos con fertilidad reciente.Resultados. Mediante el análisis discriminante se obtuvo una función que permitió clasificar los dos grupos analizados así: un valor menor de 0,50 para el 86,1 % de los individuos del grupo de muerte embrionaria temprana recurrente y un valor mayor de 0,50 para clasificar el 81,8 % de los individuos del grupo de fertilidad reciente. Conclusiones. Este valor de referencia de 0,5, basado en los resultados de los análisis espermáticos y utilizando el análisis discriminante, permitiría categorizar a los pacientes que consulten por historia de muerte embrionaria temprana en sus parejas y le ayudaría al médico a sugerir un tratamiento más enfocado en la posible causa de la disminución de la fertilidad.Palabras clave: espermatozoide, aborto espontáneo, estrés oxidativo, cromatina, antioxidantes, fertilidad. Evaluation of atypical semen parameters in individuals whose couples had a history of early recurrent embryo death: in search for a reference valueIntroduction. Previous studies related alterations in non-conventional seminal parameters with recurrent early embryonic death for one couple. A reference standard of clinical assessment is required for the management of these kinds of patients. Objective. Normal semen parameters were established based on functional tests including lipid peroxidation of sperm membranes, antioxidant capacity of seminal plasma and integrity of sperm chromatin to compare with men whose partners have recurrent early embryonic death. These parameters set reference values to identify subfertile individuals whose condition can be attributed to altered semen parameters. Materials and methods. The conventional and non-conventional semen parameters of 47 samples of semen were evaluated. Thirty-six samples were from subfertile individuals whose partners had a history of early recurrent embryo death, and 11 samples were from individuals with recent evidence of normal fertility.Results. By discriminant...

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Sperm Oxidative Stress and the Effect of an Oral Vitamin E and Selenium Supplement on Semen Quality in Infertile Men

Cited by 302 publications

References 45 publications

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

The role of antioxidant therapy in the treatment of male infertility: an overview

Evaluación de parámetros seminales no convencionales en individuos cuyas parejas presentan muerte embrionaria temprana recurrente: en busca de un valor de referencia

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