Spermatogenesis in agricultural workers exposed to dibromochloropropane (DBCP)

Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane

“…Male workers with DBCP-induced oligospermia or azoospermia had increased levels of FSH, and normal levels of testosterone (15,16). In animals, testicular damage by DBCP is accompanied by hematopoietic toxicity such as anemia, leukopenia, or bone marrow hypoplasia (1 1, 17).…”

Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane

“…The major effects were azoospermia or oligospermia. Sandifer et al (1979) showed significant differences in median sperm counts among formulators, custom applicators, and farmers.…”

Health effects classification and its role in the derivation of minimal risk levels: Reproductive and endocrine effects

“…Even for chemicals well known to target human reproductive system, such as 1,2-dibromo-3-chloropropane, a health-based guidance value related to observed effects in humans is difficult to derive. Most available data came from occupational settings, in case of 1,2-dibromo-3-chloropropane, from cohorts of workers exposed to this nematocide during production at factories (Potashnik et al, 1978;Whorton et al, 1979), and from cohorts of applicators and farmers (Glass et al, 1979;Sandifer et al, 1979) and actual levels of exposure were not established. Animal studies intended to investigate reproductive effects should follow certain protocols that were outlined elsewhere (EPA, 1991(EPA, , 1996(EPA, , 1998FDA, 1993).…”