Spermatogenesis in Drosophila

Hackstein, J.H.P.

doi:10.1007/978-3-540-47184-4_2

Cited by 42 publications

(11 citation statements)

References 121 publications

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“…1). In both species the size of the Y chromosome is greater than 40 Mb and is roughly equivalent to about 10 % of the haploid genome (Hackstein, 1987). D. melanogaster belongs to the Sophophora subgenus and D. hydei to the Drosophila subgenus, family Drosophilidae.…”

Section: Resultsmentioning

confidence: 99%

Biased distribution of repetitive elements: a landmark for neo-Y chromosome evolution in <i>Drosophila miranda</i>

Steinemann

Steinemann²

2001

Cytogenet Genome Res

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It is generally assumed that the sex chromosomes developed from a pair of homologs. Over evolution, the proto-Y chromosome, with a very short differential segment, matured in its final stage into a heterochromatic and, for the most part, genetically eroded Y chromosome. The constraints on the evolution of the proto-Y chromosome have been speculated upon since the sex chromosomes were discovered. Several models have been suggested. Drosophila miranda has proved to be a unique and potent model system to study Y-chromosome evolution. We use selected test genes distributed along the neo-Y chromosome as entry gates to analyze the molecular mechanisms involved in the process of Y-chromosome evolution. Here, we report our findings on the Krüppel gene (Kr), which is located distally on the neo-sex chromosome pair.

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Section: Resultsmentioning

confidence: 99%

Biased distribution of repetitive elements: a landmark for neo-Y chromosome evolution in <i>Drosophila miranda</i>

Steinemann

Steinemann²

2001

Cytogenet Genome Res

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“…We conclude that the nucleolar organizing activity of secondary constrictions is an intrinsic property of the rDNA or its'RNA products. Thus, the relationship between rDNA and nucleoli may be analogous to other nuclear structures that are associated with highly active transcription units, such as puffs (Ritossa 1964;Simon et al 1985a, b) and lampbrush loops in oocytes (Callan 1986) and spermatocytes (for review, see Hackstein 1987).…”

Section: Rdna and The Nomentioning

confidence: 99%

A Drosophila rRNA gene located in euchromatin is active in transcription and nucleolus formation.

Karpen¹,

Schaefer²,

Laird³

1988

Genes & Development

159

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P-element transformants of a single rRNA gene (rDNA) were used to investigate the relationship between the organization of the nucleolus organizer (NO) and rDNA function in Drosophila melanogaster. In situ hybridization to rRNA in polytene nuclei of salivary glands demonstrated that an rRNA gene can be transcribed at a high rate when inserted into chromosomal sites other than the NO. Structures that resemble morphologically the endogenous nucleoli ('mininucleoli') were associated with four different euchromatic sites of rDNA insertion. Molecular analyses revealed that these mininucleoli contained both rRNA and an antigen specific to nucleoli. Phenotypes resulting from rDNA deficiencies were rescued partially by the presence of the transformed rDNA, indicating that the transcripts and mininucleoli associated with the rDNA insertion sites were functional. Thus, two conserved features of rDNA organization in eukaryotes, namely tandem repetition and heterochromatic localization, are not required for rRNA gene function. We conclude that 'nucleolar organizing activity' is an intrinsic property of the rDNA or its RNA products.

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“…As already mentioned, the Y chromosome of Drosophila is not involved in sex determination or realization; in most but not all cases it controls male fertility (28). Whereas mutations in these fertility genes identify distinct, unique functions in spermatogenesis, mutations of the non-coding repetitive DNA sequences can cause a number of puzzling, normally dose-dependent effects.…”

Section: Drosophilamentioning

confidence: 99%

Is the Y chromosome of Drosophila an evolved supernumerary chromosome?

et al. 1996

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SummaryThe Y chromosomes of most Drosophila species are necessary for male fertility but they are not involved in sex determination. They have many puzzling properties that resemble the effects caused by B chromosomes. Classical genetic and molecular studies reveal substantial affinities between Y and B chromosomes and suggest that the Y chromosomes of Drosophila are not degenerated homologues of the X chromosomes, but rather that their Y chromosomes evolved Accepted 7 December 1995 as specialized supernumeraries similar to classical B chromosomes.

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Spermatogenesis in Drosophila

Cited by 42 publications

References 121 publications

Biased distribution of repetitive elements: a landmark for neo-Y chromosome evolution in <i>Drosophila miranda</i>

Biased distribution of repetitive elements: a landmark for neo-Y chromosome evolution in <i>Drosophila miranda</i>

A Drosophila rRNA gene located in euchromatin is active in transcription and nucleolus formation.

Is the Y chromosome of Drosophila an evolved supernumerary chromosome?

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