Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD

Fertility After Allogeneic Hematopoietic Stem Cell Transplantation: A 23-Year Review From A Tertiary Hospital.

“…3 Recovery of fertility after HSCT therapy has been reported in both sexes; in males the rate of spermatogenesis may increase with time. 4 Successful pregnancies after HCST have been reported in previous studies. 5 In this study, we investigated the pregnancy outcomes and factors related to infertility in our patients after allo-HSCT.…”

“…These time periods are consistent with the observation that spermatogenesis recovers in 20% to 25% of HCT patients after prolonged follow-up. 4 Longer follow-up is important if fertility is desired.…”

Spontaneous conception after autologous hematopoietic stem cell transplantation: a case report

“…2 While few cases of successful conception or spermatogenic recovery after HSCT, with chemotherapy alone, or combined with TBI conditioning, have been reported 1, [3][4][5][6][7][8][9][10][11][12] (Table 1), other studies assessing male fertility after HSCT have not reported any conception, highlighting the increased risk of altered reproductive function after HSCT. In 2010, the patient was still in complete remission.…”

Paternity wishes in long-term survivors after allogeneic hematopoietic SCT. A study of the late effects working party of the EBMT

“…Fertility and paternity issues are frequent problems that long-term survivors and their respective partner face and it represents a challenge for the transplantation team. Several published studies have reported data on the rate of paternity after allogeneic HSCT, [4][5][6][7] however, these publications did not address patient attitudes and the wish of paternity after HSCT.…”