Spermatotoxic Effects of Nickel in Mice

Pandey, Ratna; Srivastava, S. P.

doi:10.1007/s001289910025

Cited by 39 publications

(32 citation statements)

References 5 publications

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“…Chromium is a trace element, which has generated increased interest in recent years due to its essential character. Chromium acts as a cofactor in maintaining the normal metabolism of glucose [33]. Chromium upper acceptable concentration in drinking water [32] is 100 μ g/L.…”

Section: Resultsmentioning

confidence: 99%

Isotopic and Elemental Determination in Some Romanian Apple Fruit Juices

Măgdaş

Dehelean

Puşcaş

2012

The Scientific World Journal

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H, C, O stable isotope ratios and the content of some heavy elements of 31 Romanian single-strength organic apple juices collected from four Transylvanian areas are discussed in this study. The aim of this study was to measure the 2H/1H, 18O/16O, 13C/12C ratios of these juices and their elemental profile and to establish a database of authentic values to be used for adulteration and authenticity testing. Our results have shown mean values of δ 18O = −4.2‰ and δDδ−46.5‰, respectively, for apples from Transylvania and at the same time the mean value of δ 13C = −28.2‰. The content of Cd, Pb, U, Zn, As was below the acceptable limits stipulated in US-EPA standard for drinking water. Cu and Cr limits exceeded for one single juice; Ni content for some apple juices from Maramures, Alba, and Cluj was higher than the acceptable value.

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Section: Resultsmentioning

confidence: 99%

Isotopic and Elemental Determination in Some Romanian Apple Fruit Juices

Măgdaş

Dehelean

Puşcaş

2012

The Scientific World Journal

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“…On the other hand, it was also documented that Ni has adversative effects on spermatozoa as well as on the structure and function of prostate gland, seminal vesicles and testis (Massanyi et al 2005). Furthermore, many studies, reporting animal mice models, have evidenced the links between spermatozoa-toxic effects and nickel (Pandey and Srivastava 2000).…”

Section: Nickel (Ni)mentioning

confidence: 96%

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Zafar

Eqani

Bostan

et al. 2014

Environ Geochem Health

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Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p < 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = -0.26, -0.29) and motility (r = -0.33, -0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.

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“…Pandey and Srivastava [32] reported spermatotoxic effects of Ni 2+ in mice. The animals were treated with 5, 10, or 20 mg/kg bw NiSO 4 or NiCl 2 orally (5 days/week) for 35 days.…”

Section: Spermatotoxicitymentioning

confidence: 98%

Reproductive toxicology of nickel – Review

Forgács¹,

Massányi

Lukáč

et al. 2012

Journal of Environmental Science and Health, Part A

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The goal of this minireview is to summarize our current knowledge on the reproductive toxicity of soluble nickel salts. We made an attempt to present the most relevant data obtained from in vivo and in vitro experiments performed on mammals, mammalian primary cell cultures and cell lines. Nickel has been demonstrated to disturb the mammalian reproductive functions at several levels of regulation. The results of previous investigations indicate that the hormonal effects may play an important role in the reproductive toxicology of nickel both at the neuroendocrine and gonadal levels in the hypothalamic-pituitary-gonadal (HPG) axis. At the molecular level, it may be important that nickel may substitute certain other metals in metal dependent enzymes, leading to an altered protein function. It readily crosses the cell membrane via calcium channels and competes with calcium for specific receptors. Nickel can cross-link aminoacids to DNA, lead to formation of reactive oxygen species (ROS), moreover mimic hypoxia. These changes may lead to the activation of some signaling pathways, subsequent transcription factors and eventually to alterations in gene expression and cellular metabolism. These events are likely to be involved in the reproductive toxicity of nickel.

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Spermatotoxic Effects of Nickel in Mice

Cited by 39 publications

References 5 publications

Isotopic and Elemental Determination in Some Romanian Apple Fruit Juices

Isotopic and Elemental Determination in Some Romanian Apple Fruit Juices

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Reproductive toxicology of nickel – Review

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