Spermicidal action of a protein isolated from ethanolic root extracts of Achyranthes aspera: An in vitro study

Anuja, M.M.; Nithya, R.; Swathy, S.; Rajamanickam, C.; Indira, M.

doi:10.1016/j.phymed.2011.01.007

Cited by 10 publications

(6 citation statements)

References 9 publications

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“…158 A follow up study with the same protein, showed that it has antifertility effect on human males. 159 Similar study to references 156 and 157. 160 Chemical composition Selected articles that reported general chemical composition, which means, natural products families (phenolics, carbohydrates … etc.…”

Section: Reproductive System Sexsupporting

confidence: 71%

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Azab¹

2020

ECB

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Section: Reproductive System Sexsupporting

confidence: 71%

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Azab¹

2020

ECB

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“…Reddy et al, 2004 [20] observed that Nisin, a 34 amino acid cationic peptide produced by Lactococcus lactis has sperm immobilization effect. A 52 kDa protein isolated from 50% ethanolic extract of the root bark of Cananga odorata [21] and a 58 kDa protein from Achyranthes aspera [22] were also reported to have similar spermatotoxicity in male animals.…”

Section: Discussionmentioning

confidence: 99%

Effects on spermatogenesis in swiss mice of a protein isolated from the roots of Ricinus communis (Linn.) (Euphorbiaceae)

Nithya

Anuja

Swathy

et al. 2011

Journal of Hazardous Materials

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“…The root of A. aspera possesses a protein responsible for spermatotoxicity in Swiss male albino mice when administered orally [83]. The isolated 58kDa Achyranthes protein (Ap) shows stronger spermicidal activity at a dose of 150 μg compared to nonoxynol-9 at a dose of 250 μg by in-vitro [84]. This protein produces an irreversible spermicidal effect.…”

Section: Antifertilitymentioning

confidence: 99%

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

Nargatti¹,

Patil²,

Wadkar³

2021

JPRI

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Background: Achyranthes asperaLinn, commonly known as Apamarga in Ayurveda (Prickly Chaff flower in English, Aghara in Hindi, Aghada in Marathi), is aannual, perennial herb that belong to Family Amaranthaceae and Genus Achyranthes consisting of several species which are popular as folk remedies. Certain ayurvedic and Unani practitioners use various parts of plant to treat various diseases.The present review aims to provide up-to-date information on different aspects of plant involving its botanical description, phytochemistry and bioactivities of different extractsto assess its therapeutic potential as a valuable source of natural compounds with beneficial effects on human health. Methodology: Systematic search of scientific databases like Google, Google scholar, PubMed, Web of Science, Science Direct, SciFinder, Springer link were used to find potentially significant scientific research and reports of Achyranthes asperaLinnusing combination of relevant keywords. Results: Achyranthes aspera Linn is a popular folk remedy in the traditional medicinal system in all tropical Asian and African countries. So far,58 important compounds have been isolated and identified from various parts of plant. These isolated constituents are mainly flavonoids, tannins, terpenoids, saponins, phytosterols; phenolic compounds etc which posseses activities like anti-inflammatory, antimicrobial, anti-oxidant, hypoglycemic, antihyperlipidemic, spermicidal and other various important medicinal properties. Conclusion: Even though this plant consists of a wide range of phytochemicals and evaluated forbiological activities using various in-vitro and in-vivo models but they are limited. More attention should be paid to identify mechanisms that underlie beneficial therapeutic potential.It is essential to conduct the next level of research, by extending pharmacological to design novel drugs.

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Spermicidal action of a protein isolated from ethanolic root extracts of Achyranthes aspera: An in vitro study

Cited by 10 publications

References 9 publications

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Effects on spermatogenesis in swiss mice of a protein isolated from the roots of Ricinus communis (Linn.) (Euphorbiaceae)

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

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