Spermidine in dementia

Pekar, Thomas; Wendzel, Aribert; Flak, Walter; Kremer, Alexandra; Pauschenwein-Frantsich, Susanne; Gschaider, Anna; Wantke, F.; Jarisch, Reinhart

doi:10.1007/s00508-019-01588-7

Cited by 32 publications

(24 citation statements)

References 16 publications

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“…Whether exercise-induced oxidative stress might exert protective effects through the activation of antioxidant response mechanisms in this population remains to be determined. Spermidine is a polyamine metabolite (50) that has been implicated in cognitive function and AD (116,117) and may alleviate oxidative stress. Increased dietary intake of spermidine is considered beneficial for brain function in people with dementia (116).…”

Section: Discussionmentioning

confidence: 99%

“…Spermidine is a polyamine metabolite (50) that has been implicated in cognitive function and AD (116,117) and may alleviate oxidative stress. Increased dietary intake of spermidine is considered beneficial for brain function in people with dementia (116). Consistent with our findings of other antioxidant metabolites, spermidine was diminished in the EPA group.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

et al. 2021

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Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. To begin to address this issue, we utilized blood samples of 23 asymptomatic late middle-aged adults, with familial and genetic risk for AD (mean age 65 years old, 50% female) who underwent 26 weeks of supervised treadmill training. Systemic biomarkers implicated in learning and memory, including the myokine Cathepsin B (CTSB), brain-derived neurotrophic factor (BDNF), and klotho, as well as metabolomics were evaluated. Here we show that aerobic exercise training increases plasma CTSB and that changes in CTSB, but not BDNF or klotho, correlate with cognitive performance. BDNF levels decreased with exercise training. Klotho levels were unchanged by training, but closely associated with change in VO2peak. Metabolomic analysis revealed increased levels of polyunsaturated free fatty acids (PUFAs), reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis, with exercise. Multiple metabolites (~30%) correlated with changes in BDNF, but not CSTB or klotho. The positive association between CTSB and cognition, and the modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function. Overall, our analyses indicate metabolic regulation of exercise-induced plasma BDNF changes and provide evidence that CTSB is a marker of cognitive changes in late middle-aged adults at risk for dementia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

et al. 2021

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“…A clear correlation was established between spermidine concentration and improvement in cognitive performance in patients with mild to moderate dementia. Simultaneous dietary administration of 200 µg putrescine, 900 µg spermidine, and 500 µg spermine (total 1600 µg) per day for 12 months in elderly people had the most effective positive effect on cognitive processes [ 89 , 90 ].…”

Section: The Influence Of Introducing Polyamines To the Diet On Cogni...mentioning

confidence: 99%

The Role of Polyamines in the Mechanisms of Cognitive Impairment

et al. 2022

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—As the population ages, age-related cognitive impairments are becoming an increasingly pressing problem. Currently, the role of polyamines (putrescine, spermidine, and spermine) in the pathogenesis of cognitive impairments of various origin is actively discussed. It was shown that the content of polyamines in the brain tissue decreases with age. Exogenous administration of polyamines makes it possible to avoid cognitive impairment and/or influence the pathogenetic processes associated with disease progression. There are 3 known ways that polyamines can enter the human body: food, synthesis by intestinal bacteria, and biosynthesis in the body. Currently, one of the most promising approaches to the prevention of cognitive impairment is the use of foods with a high content of polyamines, as well as the use of various probiotics that affect intestinal bacteria that synthesize polyamines. Since 2018, in a number of European countries projects have been launched aimed at evaluation of the impact of a diet high in polyamines on cognitive processes. The review, based on analysis of modern scientific literature and the authors' own data, presents material on the effect of polyamines on cognitive processes and the role of polyamines in the regulation of neurotransmitter processes, and discusses the role of polyamines in cognitive disorders in mental and neurological diseases.

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“…The preliminary results already showed a significant correlation between the spermidine levels in serum and memory performance [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The positive effect of spermidine in older adults suffering from dementia

Pekar

Bruckner

Pauschenwein-Frantsich

et al. 2020

Wien Klin Wochenschr

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SummaryThe worldwide prevalence of dementia is estimated at 35.6 million and will rise to 115 million by 2050. There is therefore an urgent need for well-founded dementia diagnostics and well-researched therapeutic options. Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. They also confirmed that nutritional intervention with the natural polyamine spermidine can prevent memory loss in aging model organisms. This multicentric double-blind preliminary study focused on the effect of oral spermidine supplementation on older adults’ cognitive performance. Memory tests were carried out on 85 subjects aged between 60 and 96 years in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration and measurement of metabolic parameters. The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group treated with the higher spermidine dosage. The most substantial improvement in test performance was found in the group of subjects with mild dementia with an increase of 2.23 points (p = 0.026) in the mini mental state examination (MMSE) and 1.99 (p = 0.47) in phonematic fluidity. By comparison, the group which had a lower spermidine intake showed consistent or declining cognitive performance.

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Spermidine in dementia

Cited by 32 publications

References 16 publications

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

The Role of Polyamines in the Mechanisms of Cognitive Impairment

The positive effect of spermidine in older adults suffering from dementia

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