1996
DOI: 10.1002/aheh.19960240312
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Spezielle Ökologie Limnische Systeme. Von H. W. Bohle Springer‐Verlag, Berlin, 1995, ISBN 3‐540‐58263‐0, 267 S., brosch., DM 48,–

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“…6 Approximately 5% to 14% of DLBCLs have MYC rearrangements, which have been confirmed to be associated with an unfavorable clinical course. [7][8][9] The BCL2 gene encodes a protein that regulates the apoptotic process, and elevated levels of BCL2 can provide resistance to cell death. 10 The BCL2/18q21 rearrangement is detected in approximately 20% to 30% of DLBCLs, and this rearrangement plays an important role in the pathogenesis of DLBCL.…”
Section: Introductionmentioning
confidence: 99%
“…6 Approximately 5% to 14% of DLBCLs have MYC rearrangements, which have been confirmed to be associated with an unfavorable clinical course. [7][8][9] The BCL2 gene encodes a protein that regulates the apoptotic process, and elevated levels of BCL2 can provide resistance to cell death. 10 The BCL2/18q21 rearrangement is detected in approximately 20% to 30% of DLBCLs, and this rearrangement plays an important role in the pathogenesis of DLBCL.…”
Section: Introductionmentioning
confidence: 99%
“…7 Recent studies have suggested that chromosomal aberrations of the MYC and/or the BCL2 gene locus are associated with a very unfavorable prognosis in aggressive B-cell lymphomas. [8][9][10][11][12][13] Classification of these neoplasms is frequently problematic as their features fall within a morphologic and immunophenotypic spectrum that include Burkitt-like lymphoma, atypical Burkitt lymphoma, diffuse large B-cell lymphoma with high-grade features, and high-grade B-cell lymphoma not otherwise specified. 13 Although these lymphomas do not express a homogeneous phenotype, most of them have a high proliferation (Ki-67) rate (from 60% to 100%).…”
Section: Novel Uses For "Old" Markers In Hematopathology Ki-67mentioning
confidence: 99%