Sphenoid sinus neuroendocrine carcinoma

Jayme, Eduardo Matarolo; Morimoto, Tauy Pereira; Lozano, Thales Masirevic; Campos, Zelia; Castro, Cláudio Campi de

doi:10.1259/bjrcr.20150334

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Occupational exposure to wood dust, leather, flour, tissue, and other industrial compounds (chromium and nickel), exposure to glues, formaldehyde, and organic solvents are shown to have a causal role in the development of TuNSs in several studies. For this reason, TuNSs are officially recognized as “occupational diseases” [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Additional non-occupational risk factors for TuNSs development include tobacco, nasal polyposis, inverted sinusal papilloma [ 16 , 17 ], chronic sinusitis and, finally, radiotherapy used for the treatment of retinoblastoma, a hereditary eye tumor that generally affects children.…”

Section: Etiopathogenesis Of Tunssmentioning

confidence: 99%

“…Prognostic factors include age, performance status, tumor location and local extension, histotype, presence or lack of perineural invasion. For example, about the precise site of origin, carcinomas arising from the nasal cavity show a better prognosis than those from the paranasal sinuses, likely because nasal carcinomas give rise to symptoms (e.g., nasal obstruction or epistaxis) coming earlier to clinical attention [ 1 , 2 , 3 , 4 , 5 , 10 , 14 , 16 , 17 ]. In addition, among maxillary sinus carcinomas, those arising from the anterior-inferior portion have a better prognosis than those arising from the superior-posterior portion, likely because the latter group has easier access to structures such as the orbit or skull base.…”

Section: Clinical Aspects and Prognosismentioning

confidence: 99%

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Malignant Sinonasal Tumors: Update on Histological and Clinical Management

et al. 2021

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Tumors of nasal cavity and paranasal sinuses (TuNSs) are rare and heterogeneous malignancies, presenting different histological features and clinical behavior. We reviewed the literature about etiology, biology, and clinical features of TuNSs to define pathologic features and possible treatment strategies. From a diagnostic point of view, it is mandatory to have high expertise and perform an immunohistochemical assessment to distinguish between different histotypes. Due to the extreme rarity of these neoplasms, there are no standard and evidence-based therapeutic strategies, lacking prospective and large clinical trials. In fact, most studies are retrospective analyses. Surgery represents the mainstay of treatment of TuNSs for small and localized tumors allowing complete tumor removal. Locally advanced lesions require more demolitive surgery that should be always followed by adjuvant radio- or chemo-radiotherapy. Recurrent/metastatic disease requires palliative chemo- and/or radiotherapy. Many studies emphasize the role of specific genes mutations in the development of TuNSs like mutations in the exons 4–9 of the TP53 gene, in the exon 9 of the PIK3CA gene and in the promoter of the TERT gene. In the near future, this genetic assessment will have new therapeutic implications. Future improvements in the understanding of the etiology, biology, and clinical features of TuNSs are warranted to improve their management.

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Section: Etiopathogenesis Of Tunssmentioning

confidence: 99%

Section: Clinical Aspects and Prognosismentioning

confidence: 99%

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

et al. 2021

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“…4) Primary intracranial NETs are extremely rare entities, and to date, only 12 cases have been reported in the literature. 1,[4][5][6][7][8][9][10][11][12][13] Most were located in the skull base and sellar regions, except for one case each in the third ventricle, 1) frontal convexity, 6) parietal lobe, 9) and cerebellum. 13) Based on the pathological findings of the present case, we consider that the differential diagnosis of NETs should include esthesioneuroblastoma and ectopic sparsely granulated corticotroph adenoma (SGCA).…”

Section: Discussionmentioning

confidence: 99%

Primary Intracranial Neuroendocrine Tumor of the Skull Base Complicated with Tension Pneumocephalus after Radiotherapy

Kambe

Nakajima

Fukushima

et al. 2021

NMC Case Report Journal

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Neuroendocrine tumors (NETs) are neoplasms that originate from cells of the endocrine and nervous systems, and are commonly found in the gastrointestinal and respiratory tracts. Primary intracranial NETs are extremely rare and have been the focus of only a few studies thus far. Herein, we report the case of a primary intracranial NET of the skull base complicated with tension pneumocephalus after radiotherapy. An 84-year-old woman visited a local hospital for a head injury, and CT revealed a skull base tumor. MRI showed that the tumor was located mainly on the clivus and extended into the paranasal sinuses and nasal cavity. We biopsied the tumor via the nasal cavity, and the pathological diagnosis was NET, WHO grade 2. We subsequently administered focal intensity-modulated radiation therapy, but the patient developed tension pneumocephalus 1 year after radiotherapy. We therefore performed endoscopic transnasal cerebrospinal fluid leak closure with a nasoseptal flap. The postoperative course was successful, and the patient returned home but died of an unknown cause 2 years after discharge. The optimal postoperative management of primary intracranial NETs remains controversial. Tension pneumocephalus related to radiotherapy is a rare complication. Assessing skull bone erosion before radiotherapy and performing regular radiological follow-up examinations are essential to prevent this rare complication.

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“…An MRI provides detailed information on the relationships between the tumor and the surrounding structures; therefore, this technique is superior in assessing dural invasion and perineural and arterial encasement. CT scans with multiplanar reconstructions, on the other hand, are more helpful in characterizing the degree and extent of bony erosion [ 35 , 36 ] (Fig. 14 ).…”

Section: Tumorsmentioning

confidence: 99%

Sphenoid sinus anatomical variants and pathologies: pictorial essay

Sethi,

Choudhary,

Ganesan

et al. 2023

Neuroradiology

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The sphenoid sinus (SS) is one of the four paired paranasal sinuses (PNSs) within the sphenoid bone body. Isolated pathologies of sphenoid sinus are uncommon. The patient may have various presentations like headache, nasal discharge, post nasal drip, or non-specific symptoms. Although rare, potential complications of sphenoidal sinusitis can range from mucocele to skull base or cavernous sinus involvement, or cranial neuropathy. Primary tumors are rare and adjoining tumors secondarily invading the sphenoid sinus is seen. Multidetector computed tomography (CT) scan and magnetic resonance imaging (MRI) are the primary imaging modalities used to diagnose various forms of sphenoid sinus lesions and complications. We have compiled anatomic variants and various pathologies affecting sphenoid sinus lesions in this article.

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Sphenoid sinus neuroendocrine carcinoma

Cited by 3 publications

References 6 publications

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

Primary Intracranial Neuroendocrine Tumor of the Skull Base Complicated with Tension Pneumocephalus after Radiotherapy

Sphenoid sinus anatomical variants and pathologies: pictorial essay

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