Spherulitic growth rates and morphology of absorbable poly(<i>p</i>‐dioxanone) homopolymer and its copolymer by hot‐stage optical microscopy

Andjelić, Saša; Jamiolkowski, Dennis D.; McDivitt, James; Fischer, Jerome; Zhou, Jiangying

doi:10.1002/polb.10065

Cited by 25 publications

(31 citation statements)

References 34 publications

(50 reference statements)

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“…Kinetic analysis using DSC data suggests a slightly lower transition temperature (66 °C, against 78 °C obtained from microscopy) than that deduced by microscopy. A similar difference in transition temperatures between DSC and HSOM has been reported, for example, for polydioxanone, whose slow crystallization rate allows an accurate analysis covering a wide temperature range to be performed 40. Perhaps the most striking discrepancy is in the transport activation energy U *, obtained by the two methods.…”

Section: Resultssupporting

confidence: 62%

Isothermal crystallization kinetics and spherulitic morphology of poly(4‐hydroxybutyric acid‐alt‐glycolic acid)

Martínez-Palau¹,

Franco²,

Puiggalı́³

et al. 2007

J Polym Sci B Polym Phys

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Isothermal crystallization behavior of a new regular polyester constituted by glycolic acid and 4‐hydroxybutyric acid units is studied by means of differential scanning calorimetry and hot‐stage optical microscopy. A wide range of crystallization conditions were experimentally accessible, allowing various morphological features to be observed and accurate estimates made of characteristic growth parameters, including radial growth and nucleation rates. Three‐dimensional spherulitic growth from heterogeneous nuclei is deduced from the Avrami analysis, whereas optical micrographs reveal two different spherulitic textures that agree with the existence of two crystallization regimes. These can be well distinguished from the breaks observed in the Lauritzen and Hoffman plots when the linear crystal growth rate or the overall crystallization rate is considered. Ringed and nonringed spherulites with negative and positive birefringence, respectively, can be obtained depending on crystallization conditions and regimes. The studied polyester shows rather complex melting behavior which is interpreted in terms of a recrystallization process involving the two different kinds of spherulites. This study allows polymorphism to be discounted. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 2640–2653, 2007

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Section: Resultssupporting

confidence: 62%

Isothermal crystallization kinetics and spherulitic morphology of poly(4‐hydroxybutyric acid‐alt‐glycolic acid)

Martínez-Palau¹,

Franco²,

Puiggalı́³

et al. 2007

J Polym Sci B Polym Phys

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“…As PDO is emerging as an attractive biodegradable polymer; however, there is still a lack of understanding in its structure–property relationships. For example, although both isothermal and nonisothermal crystallization kinetics of PDO have been studied , there is no report on its effect on mechanical and degradation properties as of yet. Furthermore, to our best knowledge, there are few reports on molecular weight measurements, mainly because of limited instrumentation capable of accommodating hexafluoroisopropanol (HFIP), which is the best solvent for high‐molecular‐weight PDO .…”

Section: Introductionmentioning

confidence: 99%

Influence of thermal annealing on mechanical properties andin vitrodegradation of poly(p‐dioxanone)

Zhang¹,

Jones²,

Wang³

et al. 2019

Polymer Engineering & Sci

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Poly(p‐dioxanone) (PDO), a versatile poly(ester‐ether), has been used for a variety of biomedical applications. Functional performance of this semicrystalline polymer heavily relies on its crystallinity and crystalline behavior. Upon extended exposure to heat above the glass transition temperature and below the melting temperature, PDO undergoes thermal annealing. Isothermal studies at elevated temperatures utilizing a differential scanning calorimeter were performed in order to determine the most appropriate conditions to anneal the polymer. Of the investigated mechanical properties, yield strength and elastic modulus were significantly improved with annealing. This improvement over nonannealed samples was also observed with samples subjected to phosphate‐buffered saline (PBS) solution at 37°C for 2 weeks. After 1 month continuous immersion in PBS solution, the PDO became brittle with deteriorated elongation at break but maintained yield strength and modulus. At 2 months, all specimens exhibited cracks on the surface and a complete loss of mechanical strength. The enhanced yield strength by thermal annealing creates more opportunities for PDO in medical device implants particularly in applications involving soft tissue repair and hemostasis. POLYM. ENG. SCI., 59:1701–1709 2019. © 2019 Society of Plastics Engineers

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“…Although many researchers have investigated the degradation behavior, spherulitic crystallization mechanism, and mechanical and thermal properties of this attractive PPDX for the medical device and pharmaceutical fields, [10][11][12][13][14][15][16][17][18][19][20] almost no detailed analysis of the crystal structure and conformation of PPDX has been reported. In this paper, we report the first preparation of lamellar crystals of PPDX grown from a dilute solution by isothermal crystallization.…”

Section: Introductionmentioning

confidence: 99%

X‐Ray and Electron Diffraction Study of Poly(p‐dioxanone)

Furuhashi

Nakayama

Monno

et al. 2004

Macromol. Rapid Commun.

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Summary: Solution‐grown lamellar crystals of poly(p‐dioxanone) (PPDX) have been crystallized isothermally from butane‐1,4‐diol at 100 °C. The crystal structure of PPDX has been determined by interpretation of X‐ray fiber diagrams of PPDX fibers and electron diffraction diagrams of lozenge‐shaped chain‐folder lamellar crystals. The unit cell of PPDX is orthorhombic with space group P212121 and parameters: a = 0.970 nm, b = 0.742 nm, and c (chain axis) = 0.682 nm. There are two chains per unit cell, which exist in an antiparallel arrangement.Transmission electron micrograph of PPDX chain‐folded lamellar crystals obtained by isothermal crystallization and its electron diffraction diagram.imageTransmission electron micrograph of PPDX chain‐folded lamellar crystals obtained by isothermal crystallization and its electron diffraction diagram.

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Spherulitic growth rates and morphology of absorbable poly(p‐dioxanone) homopolymer and its copolymer by hot‐stage optical microscopy

Cited by 25 publications

References 34 publications

Isothermal crystallization kinetics and spherulitic morphology of poly(4‐hydroxybutyric acid‐alt‐glycolic acid)

Isothermal crystallization kinetics and spherulitic morphology of poly(4‐hydroxybutyric acid‐alt‐glycolic acid)

Influence of thermal annealing on mechanical properties andin vitrodegradation of poly(p‐dioxanone)

X‐Ray and Electron Diffraction Study of Poly(p‐dioxanone)

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