Sphingophosphonolipid molecular species from edible mollusks and a jellyfish

Kariotoglou, Dimitrios M.; Mastronicolis, Sofia K.

doi:10.1016/s1096-4959(03)00168-4

Cited by 28 publications

(17 citation statements)

References 53 publications

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“…CAEP is structurally very similar to CPE except for phosphate being replaced by phosphonate with a direct C-P bond connecting phosphonate and ethanolamine (30,31). The nonhydrolyzable C-P bond would enhance stability of the lipid, especially with respect to phospholipases.…”

Section: When Incubated With Cdp-[mentioning

confidence: 99%

Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen

Vacaru

Dikkenberg

Ternes

et al. 2013

Journal of Biological Chemistry

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Background: Many invertebrates contain ceramide phosphoethanolamine (CPE) rather than sphingomyelin as key membrane component. Results: Insect-specific CPE synthase belongs to a novel branch of CDP-alcohol phosphotransferases with unique membrane topology. Conclusion: CPE production is catalyzed by a CDP-ethanolamine:ceramide ethanolamine phosphotransferase in the Golgi lumen. Significance: Identification of CPE synthase provides a novel opportunity to elucidate the biological role of an enigmatic but widespread sphingolipid.

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Section: When Incubated With Cdp-[mentioning

confidence: 99%

Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen

Vacaru

Dikkenberg

Ternes

et al. 2013

Journal of Biological Chemistry

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“…Sphingophosphonolipid composition of Pelagia noctiluca was recently defined and a suite of two ceramide 2-aminoethylphosphonic acids (CAEP) was quantified at 2.0 and 1.3% of phospholipids [65]. The pH of body fluids taken from Pelagia noctiluca collected in the intertidal zone from Laguna Beach (California) was also performed; the results showed a pH ranging from 7.304 to 7.307 [4].…”

Section: Pelagia Noctiluca: Distribution and Bloomsmentioning

confidence: 99%

“…As Pelagia noctiluca is a top predator and its feeding activity is exerted on several zooplankters, including eggs and larvae of nektonic and benthic organisms, this impact could have affected remarkably prey populations and consequently caused lower production [122]. In this connection, from the biological and ecological point of view the chemical analyses carried out on Pelagia noctiluca specimens [62,64,65] are important in order to evaluate the transfer of energy to high trophic levels as well as the amount of C and N available for microorganisms in consequence of the decomposition, which becomes more intense during outbreaks.…”

Section: Distribution and Bloommentioning

confidence: 99%

The Mauve Stinger Pelagia noctiluca (Forsskål, 1775). Distribution, Ecology, Toxicity and Epidemiology of Stings.

2008

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Abstract:The toxicity of Cnidaria is a subject of concern due to its influence on humans. In particular, jellyfish blooms can highly affect human economical activities, such as bathing, fishery, tourism, etc., as well as the public health. Stinging structures of Cnidaria (nematocysts) produce remarkable effects on human skin, such as erythema, swelling, burning and vesicles, and at times further severe dermonecrotic, cardio-and neurotoxic effects, which are particularly dangerous in sensitive subjects. In several zones the toxicity of jellyfish is a very important health problem, thus it has stimulated the research on these organisms; to date toxicological research on Cnidarian venoms in the Mediterranean region is not well developed due to the weak poisonousness of venoms of jellyfish and anemones living in this area. In spite of this, during last decades several problems were also caused in the Mediterranean by stinging consequent to Cnidarian blooms mainly caused by Pelagia noctiluca (Forsskål, 1775) which is known to be the most venomous Mediterranean jellyfish. This paper reviews the knowledge on this jellyfish species, particularly considering its occurrence and toxicity.

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“…Sphingolipids are ubiquitous in eukaryotic fungal, protozoan, animal, and plant cells and can occur in membranes as glycosphingolipids, phosphosphingolipids, and inositolsphingolipids [5][6][7][8][9][10][11][12][13][14][15]. These lipids and their precursors and metabolic products such as sphingosine, sphingosine-1-phosphate, and ceramide can be highly bioactive agents in cell proliferation, differentiation, aging, and apoptosis, transmembrane signal transduction, and other cell functions [16 -19].…”

mentioning

confidence: 99%

Detection and identification of Bacteriovorax stolpii UKi2 sphingophosphonolipid molecular species

Jayasimhulu

Hunt

Kaneshiro

et al. 2007

J. Am. Soc. Mass Spectrom.

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Bacteriovorax stolpii is a predator of larger gram-negative bacteria and lives as a parasite in the intraperiplasmic space of the host cell. This bacterium is unusual among prokaryotes in that sphingolipids comprise a large proportion of its lipids. We here report the presence of 18 molecular species of B. stolpii UKi2 sphingophosphonolipids (SPNLs).31 P NMR spectroscopy and analysis of P i released by a differential hydrolysis protocol confirmed the phosphonyl nature of these lipids. The SPNLs were dominated by those with 1-hydroxy-2-aminoethane phosphonate (hydroxy-aminoethylphosphonate) polar head groups; aminoethylphosphonate was also detected in minor SPNL components. The long-chain bases (LCBs) were dominated by C 17 iso-branched phytosphingosine; C 17 iso-branched dihydrosphingosine was also present in some SPNLs. The N-linked fatty acids were predominantly iso-branched and most contained an ␣-hydroxy group (C 15 ␣-hydroxy fatty acid was the major fatty acid). Minor molecular species containing nonhydroxy fatty acids were also detected. The definitive iso-structures of the predominant fatty acids and LCBs present in the B. stolpii SPNLs were established using 13 C and 3 H nuclear magnetic resonance spectroscopy; less than 20% were unbranched. Detection and analyses of intact compounds by MS-MS were performed by a hybrid quadrupole time-of-flight (Q-TOF-II) MS equipped with an electrospray ionization source. Analyses of peracetylated derivatives verified the structural assignments of these lipids. (J Am Soc Mass Spectrom 2007, 18, 394 -403)

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Sphingophosphonolipid molecular species from edible mollusks and a jellyfish

Cited by 28 publications

References 53 publications

Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen

Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen

The Mauve Stinger Pelagia noctiluca (Forsskål, 1775). Distribution, Ecology, Toxicity and Epidemiology of Stings.

Detection and identification of Bacteriovorax stolpii UKi2 sphingophosphonolipid molecular species

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