2018
DOI: 10.1016/j.lfs.2018.01.023
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Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF)

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Cited by 15 publications
(8 citation statements)
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“…S1P signaling has emerged as an important regulator of cardiac and vascular homeostasis [10] and has reportedly been related to the pathogenesis of multiple cardiovascular outcomes, including coronary artery disease, atherosclerosis, myocardial infarction, and/or HF [11,[52][53][54][55][56][57][58][59][60][61][62][63]. In addition to the effects of S1P on atherosclerosis, which is regarded as a major mechanism involved in ischemic cardiovascular burden, a protective role of S1P on injured myocardium elicited by nonischemic causes has also been suggested [64][65][66].…”
Section: The Effect Of S1p On the Cellular Mechanisms Involved In Carmentioning
confidence: 99%
“…S1P signaling has emerged as an important regulator of cardiac and vascular homeostasis [10] and has reportedly been related to the pathogenesis of multiple cardiovascular outcomes, including coronary artery disease, atherosclerosis, myocardial infarction, and/or HF [11,[52][53][54][55][56][57][58][59][60][61][62][63]. In addition to the effects of S1P on atherosclerosis, which is regarded as a major mechanism involved in ischemic cardiovascular burden, a protective role of S1P on injured myocardium elicited by nonischemic causes has also been suggested [64][65][66].…”
Section: The Effect Of S1p On the Cellular Mechanisms Involved In Carmentioning
confidence: 99%
“…STAT3, a transcription factor, plays a protective role in the cardiovascular diseases and the deletion of STAT3 in cardiomyocytes makes the heart more vulnerable to chronic pathological lesion ( Kurdi et al, 2018 ). Animal research data by Deshpande et al (2018) showed that activation of STAT3 has a protective effect on acute HF. YY1 also has been found to be an activator of STAT3 while interaction between STAT3 and CREB1 is not clear ( Tsui et al, 2014 ; Chen et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the results indicating that NF-κB and STAT3 are the downstream effectors of SphK2/S1P signaling have been observed in earlier studies. For example, S1P promoted the activation of STAT3 in cardiomyocytes (41), and ABC294640 blocked NF-κB activity in multidrug-resistant breast cancer cells (32).…”
Section: Discussionmentioning
confidence: 99%