We consider asymmetric spin-1 2 two-leg ladders with nonequal antiferromagnetic ͑AF͒ couplings J ʈ and J ʈ along legs ͑ Յ 1͒ and ferromagnetic rung coupling, J Ќ . This model is characterized by a gap ⌬ in the spectrum of spin excitations. We show that in the large J Ќ limit this gap is equivalent to the Haldane gap for the AF spin-1 chain, irrespective of the asymmetry of the ladder. The behavior of the gap at small rung coupling falls in two different universality classes. The first class, which is best understood from the case of the conventional symmetric ladder at = 1, admits a linear scaling for the spin gap ⌬ ϳ J Ќ . The second class appears for a strong asymmetry of the coupling along legs, J ʈ Ӷ J Ќ Ӷ J ʈ and is characterized by two energy scales: the exponentially small spin gap ⌬ ϳ J Ќ exp͑−J ʈ / J Ќ ͒, and the bandwidth of the low-lying excitations induced by a Suhl-Nakamura indirect exchange ϳJ Ќ 2 / J ʈ . We report numerical results obtained by exact diagonalization, densitymatrix renormalization group and quantum Monte Carlo simulations for the spin gap and various spin correlation functions. Our data indicate that the behavior of the string order parameter, characterizing the hidden AF order in Haldane phase, is different in the limiting cases of weak and strong asymmetries. On the basis of the numerical data, we propose a low-energy theory of effective spin-1 variables, pertaining to large blocks on a decimated lattice.