Spina bifida and anencephaly: miscarriage as possible cause.

Clarke, C. A.; Hobson, D.; McKendrick, O M; Rogers, Stephen; Sheppard, P. M.

doi:10.1136/bmj.4.5999.743

Cited by 67 publications

(33 citation statements)

References 24 publications

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“…This difference disappeared when we pooled the group of mothers with only two pregnancies and those with three or more. Therefore, our data do not confirm the reported relationship between spontaneous abortions in the preceding pregnancy and NTD [Knox, 1970;Clarke et al, 1975;Carmi et al, 1994;Adám et al, 1995]. However, as previously noted [Gardiner et al, 1978], we identified a significantly higher proportion of spontaneous abortions preceding pregnancies resulting in infants with congenital defects (either blastogenetic other than NTD or nonblastogenetic) than those producing normal liveborn infants.…”

Section: Discussioncontrasting

confidence: 75%

Are blastogenetic anomalies sporadic?

Martı́nez-Frı́as

Frías

1997

Am. J. Med. Genet.

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Opitz [Birth Defects, 1993, 1:3-37] postulated that sporadic defects of blastogenesis generally are highly lethal and have a low recurrence risk. We have observed that mothers of infants with blastogenetic defects have more previous abortions than mothers of children with nonblastogenetic defects or than mothers of control infants. Thus the high lethality of blastogenetic abnormalities may be responsible for the spontaneous abortions, and there may be a potential for an increased recurrence risk in some cases. Our results also show that the increased rate of spontaneous abortions is not similar for all blastogenetic defects, since it is not elevated in mothers of infants with neural tube defects (NTD). Further, our analysis does not confirm the relationship between spontaneous abortions in the preceding pregnancy and the occurrence of NTD previously reported by other authors.

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Section: Discussioncontrasting

confidence: 75%

Are blastogenetic anomalies sporadic?

Martı́nez-Frı́as

Frías

1997

Am. J. Med. Genet.

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“…As expected, group U had a significantly shorter pregnancy duration than others. Group A also had a shorter duration than group H, as has been reported before [8]. This finding, the wide distribution of pregnancy duration in group A, and the excess of unknown diagnoses in the shortest pregnancies ( fig.…”

Section: Short Pregnanciessupporting

confidence: 68%

“…Short intervals have been observed or predicted before affected outcomes [3,5,8,13]. However, this was not found in the present series.…”

Section: Reproductive Intervalscontrasting

confidence: 55%

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Reproductive History in Mothers of Children with Neural Tube Defects

Rivas

Dávalos

Olivares

et al. 2000

Gynecol Obstet Invest

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The reproductive history of 100 women with at least 1 child with a neural tube defect (NTD) has been studied. The data analyzed correspond to the period previous to their first visit to a genetic counseling service. A total of 204 pregnancies resulted in 205 outcomes. Of the 100 sibships, 14 (14%) had more than 1 affected member. The pregnancy was shorter than 28 weeks in 56/205 (27%) of the total outcomes. Of 104 evaluable previous outcomes, 34 corresponded to short pregnancies, positioned before an affected (23/60, 38%), a healthy (2/18, 11%), or an undiagnosed product (9/26, 35%). Short pregnancies subsequent to affected outcomes were also increased. The inter-gestational interval varied according to diagnosis: it was longer in the affected group than in the healthy one (0.1 > p > 0.05) and the subsequent intervals were shorter for the affected group (p < 0.05). An increased number of abortions adjacent to affected offspring and a changing fertility pattern, depending on the product diagnosis, point to an environmental etiological component in this high-risk NTD group of mothers.

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“…A high miscarriage rate before the birth of a child with a neural tube defect has recently been described (Clarke et al, 1975;Laurence and Roberts, 1977).…”

Section: Discussionmentioning

confidence: 99%