Spinal Anesthesia with Low-Dose Bupivacaine-Fentanyl Combination: A Good Alternative for Day Case Transurethral Resection of Prostrate Surgery in Geriatric Patients

Akçaboy, Zeynep Nur; Akçaboy, Erkan Yavuz; Mutlu, Nevzat Mehmet; Serger, Nurten; Aksu, C.; Göğüş, Nermin

doi:10.1016/s0034-7094(12)70176-9

Cited by 12 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In geriatric patients undergoing day-case transurethral resection of the prostate (TURP) surgery, Akcaboy matched intrathecal administration of a conventional dose of 50 mg 2% hyperbaric prilocaine plus fentanyl 25 μg and a low dose of 4 mg 0.5% hyperbaric bupivacaine plus fentanyl 25 μg 37. Dermatome T10 was the desired level of analgesia.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Manassero¹,

Fanelli²

2017

LRA

View full text Add to dashboard Cite

Prilocaine is a local anesthetic characterized by intermediate potency and duration and fast onset of action. As hyperbaric formulation of 5% solution, it was introduced and has been successfully used for spinal anesthesia since 1960. A new formulation of 2% plain and hyperbaric solution is currently available in Europe. Because of its lower incidence of transient neurological symptoms, prilocaine is suggested as substitute to lidocaine and mepivacaine in spinal anesthesia for ambulatory surgery, as well as a suitable alternative to low doses of long-acting local anesthetics. The National Library of Medicine database, the Excerpta Medica database, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials database, were searched for the period 1970 to September 2016, with the aim to identify studies evaluating the intrathecal use of 2% prilocaine. A total of 13 randomized clinical trials (RCTs), 1 observational study, 2 dose finding, and 4 systematic reviews has been used for this review. The studies evaluated showed that 2% hyperbaric prilocaine due to a favorable anesthetic and safety profile is an alternative drug to lidocaine and mepivacaine for spinal anesthesia of intermediate or short duration. In comparison with plain solutions, hyperbaricity remarkably accelerates the onset and offset times of intrathecal 2% prilocaine. Literature suggests a dose ranging between 40 and 60 mg of prilocaine for lower extremities and lower abdominal procedures lasting up to 90 min, whereas a dose ranging from 10 to 30 mg is appropriate for perineal surgery. Readiness for discharge occurs in ~4 h from spinal administration.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Although the combination of prilocaine and fentanyl (20–25 μg) has been tested with the aim to improve the quality and extend the duration of the spinal block, pruritus and urinary retention are possible side effects which can delay home discharge 29,36,37…”

Section: Resultsmentioning

confidence: 99%

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Manassero¹,

Fanelli²

2017

LRA

View full text Add to dashboard Cite

show abstract

“…[41][42][43] Given the increasing proportion of anesthesia administered in the ambulatory setting, 44,45 there is demand for anesthetic techniques which allow for rapid recovery with minimal side effects. 46,47 The demand for low-dose spinal techniques in ambulatory surgery highlights the need for additional studies focusing on nonobstetric populations.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Prin

Guglielminotti²,

Moitra

et al. 2016

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

show abstract

“…Hyperbaric prilocaine provides faster spinal block onset and earlier patient recovery in ambulatory surgery compared to plain prilocaine [ 14 ]. Plain prilocaine was also compared to bupivacaine in day-case surgery and the authors concluded that bupivacaine provided shorter block duration [ 15 ]. The baricity of the local anaesthetic agent is the major factor that influences the distribution of the local anaesthetic in the subarachnoid space [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Spinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled Trial

Kaban

Yazicioglu

Akkaya

et al. 2014

The Scientific World Journal

View full text Add to dashboard Cite

Background. The local anaesthetics used in day-case spinal anaesthesia should provide short recovery times. We aimed to compare hyperbaric prilocaine and bupivacaine in terms of sensory block resolution and time to home readiness in day-case spinal anaesthesia. Methods. Fifty patients undergoing perianal surgery were randomized into two groups. The bupivacaine-fentanyl group (Group B) received 7.5 mg, 0.5% hyperbaric bupivacaine + 20 μg fentanyl in total 1.9 mL. The prilocaine-fentanyl group (Group P) received 30 mg, 0.5% hyperbaric prilocaine + 20 μg fentanyl in the same volume. Results. Time to L1 block and maximum block was shorter in Group P than in Group B (Group P 4.6 ± 1.3 min versus Group B 5.9 ± 01.9 min, P = 0.017, and Group P 13.2 ± 7.5 min versus Group B 15.3 ± 6.6 min, P = 0.04). The time to L1 regression and S3 regression of the sensorial block was significantly shorter in Group P than in Group B (45.7 ± 21.9 min versus 59.7 ± 20.9 min, P = 0.024, and 133.8 ± 41.4 min versus 200.4 ± 64.8 min, P < 0.001). The mean time to home readiness was shorter for Group P than for Group B (155 ± 100.2 min versus 207.2 ± 62.7 min (P < 0.001)). Conclusion. Day-case spinal anaesthesia with hyperbaric prilocaine + fentanyl is superior to hyperbaric bupivacaine in terms of earlier sensory block resolution and home readiness and the surgical conditions are comparable for perianal surgery.

show abstract

Spinal Anesthesia with Low-Dose Bupivacaine-Fentanyl Combination: A Good Alternative for Day Case Transurethral Resection of Prostrate Surgery in Geriatric Patients

Cited by 12 publications

References 16 publications

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Prilocaine hydrochloride 2% hyperbaric solution for intrathecal injection: a clinical review

Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus

Spinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled Trial

Contact Info

Product

Resources

About