Spinal brucellosis: a review

Bouaziz, Mouna Chelli; Ladeb, Mohamed Fethi; Chakroun, M.; Chaabane, Skander

doi:10.1007/s00256-007-0371-x

Cited by 94 publications

(54 citation statements)

References 13 publications

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“…ceti infection (McDonald et al, 2006). These bone-joint lesions are not uncommon in secondary hosts such as humans brucellosis cases (Chelli-Bouaziz et al, 2008). With the solely example of occasional hygromas in cattle with brucellosis (Humphreys and Moore, 1941), joint lesions are rare in ungulates (Johnson et al, 1994).…”

Section: Brucella Induced Pathologymentioning

confidence: 99%

Brucella ceti and Brucellosis in Cetaceans

Guzmán-Verri¹,

González-Barrientos²,

Hernández-Mora³

et al. 2012

Front. Cell. Inf. Microbio.

129

178

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Since the first case of brucellosis detected in a dolphin aborted fetus, an increasing number of Brucella ceti isolates has been reported in members of the two suborders of cetaceans: Mysticeti and Odontoceti. Serological surveys have shown that cetacean brucellosis may be distributed worldwide in the oceans. Although all B. ceti isolates have been included within the same species, three different groups have been recognized according to their preferred host, bacteriological properties, and distinct genetic traits: B. ceti dolphin type, B. ceti porpoise type, and B. ceti human type. It seems that B. ceti porpoise type is more closely related to B. ceti human isolates and B. pinnipedialis group, while B. ceti dolphin type seems ancestral to them. Based on comparative phylogenetic analysis, it is feasible that the B. ceti ancestor radiated in a terrestrial artiodactyl host close to the Raoellidae family about 58 million years ago. The more likely mode of transmission of B. ceti seems to be through sexual intercourse, maternal feeding, aborted fetuses, placental tissues, vertical transmission from mother to the fetus or through fish or helminth reservoirs. The B. ceti dolphin and porpoise types seem to display variable virulence in land animal models and low infectivity for humans. However, brucellosis in some dolphins and porpoises has been demonstrated to be a severe chronic disease, displaying significant clinical and pathological signs related to abortions, male infertility, neurobrucellosis, cardiopathies, bone and skin lesions, strandings, and death.

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Section: Brucella Induced Pathologymentioning

confidence: 99%

Brucella ceti and Brucellosis in Cetaceans

Guzmán-Verri¹,

González-Barrientos²,

Hernández-Mora³

et al. 2012

Front. Cell. Inf. Microbio.

129

178

View full text Add to dashboard Cite

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“…The specificity decreases as the disease prolongs. Abscess culture gives positive findings in 10%-20% cases (10). In our patient, abscess culture was positive for Brucella, despite the SAT, Coombs test, and blood culture being negative.…”

Section: Discussionmentioning

confidence: 46%

“…In the presence of clinical symptoms, the presence of Brucella species in the culture of blood, bone marrow, or tissue must be evaluated even if the serological test results are negative. The specificity of blood culture in the diagnosis of brucellosis ranges between 17% and 85% (10). The specificity decreases as the disease prolongs.…”

Section: Discussionmentioning

confidence: 99%

Seronegative brucellosis of the spine: A case of psoas abscess secondary to brucellar spondylitis

Bozbaş

Ünübol²,

Gürer

2017

Eur J Rheumatol

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185Brucellosis is an infectious disease that affects many organ systems. Osteoarticular involvement, especially spondylitis, is the most common complication of brucellosis, but psoas abscess is very rare. Serological tests at diagnosis of the disease are very valuable and most widely used. Herein, we report a case of psoas abscess secondary to brucellar spondylitis. In this case, interestingly, the serological test results were negative, and the diagnosis could be made by abscess culture. In patients, particularly those who live in areas endemic for brucellosis, as in our case, it should be kept in mind that a negative serological test result should not exclude the diagnosis of brucellosis.

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“…The type of skeletal involvement depends on the patient's age. The spine is the targeted site in the elderly, while the sacroiliac joints and knee predominate in children and young adults2-4,7,11). Brucellar spondylitis occurs most commonly in the lumbar region.…”

Section: Discussionmentioning

confidence: 99%

Collapsed L4 Vertebral Body Caused by Brucellosis

Ekici

Özbek

Kazanci

et al. 2014

J Korean Neurosurg Soc

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Brucellosis is caused by gram-negative, aerobic, non-motile, facultative, intracellular coccobacilli belonging to the genus Brucella. A 50-year-old man working as an employee was admitted to neurosurgery clinic with severe low back, radicular right leg pain and hypoesthesia in right L4-5 dermatomes for 2 months. Brucella tube agglutination (Wright) test was positive in serum sample of the patient with a titer of 1/640. Brucella melitensis was isolated from blood culture. X-ray and MRI of the lomber spine showed massive collapse of L4 vertebral body. Neural tissue was decompressed and then posterior L3-5 short segment transpedicular screw fixation and stabilization was performed. Brucella melitensis was isolated from microbiologic culture of pathologic specimen. Antibiotic therapy was given as doxycycline 200 mg/day and rifampicin 600 mg/day for 6 months. Brucellosis is a systemic zoonotic infection and still an important public health problem in many geographical parts of the world. Vertebral body collapse caused by brucellosis occurs very rarely but represents a neurosurgical emergency because of its potential for causing rapidly progressive spinal cord compression and permanent paralysis. Neurosurgeons, emergency department personnel as well as infectious disease specialists should always keep a high index of suspicion and include brucellosis in the differential diagnosis of vertebral body collapse.

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Spinal brucellosis: a review

Cited by 94 publications

References 13 publications

Brucella ceti and Brucellosis in Cetaceans

Brucella ceti and Brucellosis in Cetaceans

Seronegative brucellosis of the spine: A case of psoas abscess secondary to brucellar spondylitis

Collapsed L4 Vertebral Body Caused by Brucellosis

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