Spinal Cord Compression in a Patient With Multiple Hereditary Exostoses Caused by Breast Adenocarcinoma Metastatic to Osteochondromas of the Spine

Pandya, Nirav K.; Auerbach, Joshua D.; Baldwin, Keith; Lackman, Richard D.; Chin, Kingsley R.

doi:10.1097/01.brs.0000245926.30594.bf

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Because chondrosarcoma has estrogen receptor, it has been proved to be sensitive to estrogen ( 15 , 16 ). The use of antiestrogen drugs may stimulate the growth of chondrosarcoma, thus increasing the risk of malignant transformation of HME into chondrosarcoma ( 17 ). Therefore, this kind of patients are not suitable for anti-estrogen treatment.…”

Section: Discussionmentioning

confidence: 99%

Hereditary multiple exostoses complicated with lung cancer with cough as the first symptom: a case report

Jia¹,

Liu²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Hereditary multiple exostoses (HME) is an autosomal dominant genetic disease. It mainly involves the extremities long bone metaphyseal and flat bone, with the cartilage cap covering the surface. The main clinical symptoms include the compression of the surrounding soft tissue caused by osteophyte hyperplasia, such as pain, dysfunction, and developmental deformity, etc. The cases of HME with lung cancer are rare. We performed a case of cough as the first symptom who had a paternal family history of HME. According to the results of positron emission tomography/computed tomography (PET/CT), pathology and immunohistochemistry, the case was finally diagnosed as right lung adenocarcinoma, T3N2M1a, stage IVA. At present, the patient was given pemetrexed with nedaplatin for 2 cycles and added anlotinib combined with chemotherapy for additional 3 cycles. The recent chest computer tomographic (CT) showed the right lung lesion was slightly smaller than before. When we meet patients of such multiple exostoses with lung occupying lesions, we need to think about many possibilities of the disease from various perspectives, such as primary lung cancer, lung metastasis or bone metastasis.

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Section: Discussionmentioning

confidence: 99%

Hereditary multiple exostoses complicated with lung cancer with cough as the first symptom: a case report

Jia¹,

Liu²,

Wu³

et al. 2020

Transl Cancer Res TCR

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“…Spinal compression syndrome may also be seen. [21] Lesions that arise in the head and neck may be associated with facial asymmetry and dysfunction of the masseters. [22,23] An inwardly growing osteochondroma can cause injuries of the viscera such as hemothorax, obstruction of the intestine or the urinary tract and dysphagia.…”

Section: Discussionmentioning

confidence: 99%

Osteochondroma. An Osteological Study

Arquez

2018

int arch med

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Background: Osteochondroma is the most common tumor of bone, accounting for approximately one third of benign lesions in the skeleton, is a broad (sessile) or narrow (pedunculated) skeletal protrusion comprised of marrow and cortical bone. Although it is benign, its biological behavior still has a malignant potential. Chondrosarcoma arising in osteochondroma has been recognized for many years. Osteochondromas might occur on any bone preformed in cartilage, they were especially seen on the long bones of the extremities, predominantly around the knee. In fact, the lower limb seemed to be at a higher risk of the tumor than the upper limb on the top two locations: distal part of the femur and proximal part of the tibia, however, the proximal humerus ranked the third place for solitary osteochondroma while the proximal fibula for multiples osteochondromas. Methods and Findings:A total of 20 skeletons and 18 cadavers of both sex, 16 males and 2 females, with different age groups were used, this study was carried out by routine dissection classes for undergraduate medical student´s in the Morphology Laboratory of the University of Pamplona during the years 2013-2016. In only one sample was found the presence of osteochondroma. The measurement of the osseous mass was of 7x3.5x1.5 cm, attached to the posterolateral aspect of the middle third of the femur. Conclusions:Osteochondroma is generally asymptomatic or discovered accidentally, but it can cause different symptoms depending on site of occurrence local swelling, bony deformities, fracture, bursa formation, arthritis and impingement on adjacent tendons, vascular or neurologic compromise, and dislocation The importance of correct treatment and follow-up of large osteochondromas to avoid complications such as further damage to neighboring neurovascular structures, and potential malignant degeneration. The present study describe a rare location from an osteochondroma in the femur diaphysis.

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Solitary Osteochondroma of the Spine—A Case Series: Review of Solitary Osteochondroma With Myelopathic Symptoms

Yakkanti

Onyekwelu

Carreon

et al. 2017

Global Spine Journal

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Study Design:Case series and literature review.Objective:There is a growing body of literature supporting that osteochondroma of the spine may not be as rare as previously documented. The purpose of this study was to perform an updated review and present our experience with 4 cases of solitary osteochondroma of the spine, including surgical treatment and subsequent outcomes.Methods:A review of 4 cases and an updated literature review.Results:All 4 cases were diagnosed as solitary osteochondroma of the spine based on clinical and histopathologic findings. Majority of the lesions arose from the posterior column with one case showing extension into the middle column with clinical neurologic sequelae. Treatment strategies for all cases included complete marginal excision of the lesions using a posterior approach. All 4 cases showed no radiographic evidence of recurrence. The literature review yielded 132 cases of solitary osteochondroma and 17 case associated with multiple hereditary exostosis. Out of the 132 cases, 36 presented with myelopathic symptoms.Conclusion:Osteochondroma of the spine may not be as rare as previously reported. The best approach to treatment in almost all symptomatic cases include wide surgical excision of the tumor. This should include complete resection of the cartilaginous cap of the tumor in an effort to prevent recurrence. When excision is performed properly, the outcomes are excellent with very low recurrence of the tumor.

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Spinal Cord Compression in a Patient With Multiple Hereditary Exostoses Caused by Breast Adenocarcinoma Metastatic to Osteochondromas of the Spine

Abstract: When faced with a patient with a history of multiple hereditary exostoses with new onset of myelopathic symptoms and a mass compressing the spinal cord, the clinician's differential should be broad and always initially include a metastatic lesion, osteochondroma, or chondrosarcoma.

Cited by 3 publications

References 29 publications

Hereditary multiple exostoses complicated with lung cancer with cough as the first symptom: a case report

Hereditary multiple exostoses complicated with lung cancer with cough as the first symptom: a case report

Osteochondroma. An Osteological Study

Solitary Osteochondroma of the Spine—A Case Series: Review of Solitary Osteochondroma With Myelopathic Symptoms

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