Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2

Lim, Bong-Suk; Park, Sukh Que; Chang, Ung-Kyu; Kim, Min Suk

doi:10.1016/j.jocn.2009.09.045

Cited by 17 publications

(12 citation statements)

References 5 publications

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“…The incidence of intramedullary gliomas in NF1 patients may be far more than their sporadic counterparts according to similar works17). Meanwhile, compared with NF22,15,25), ependymomas were reported rarely to occur in NF1 patient, to our knowledge, only three cases have been described in English literature19,21). One patient was a 7-year-old boy with NF1 which developed an ependymoma in the left temporal lobe, the tumor was totally removed and histopathological examination revealed a benign ependymoma (grade II in the WHO classification).…”

Section: Discussionmentioning

confidence: 88%

Spinal Cord Ependymoma Associated with Neurofibromatosis 1 : Case Report and Review of the Literature

Cheng

Shan

Feng

et al. 2014

J Korean Neurosurg Soc

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Patients with neurofibromatosis 1 (NF1) are predisposed to develop central nervous system tumors, due to the loss of neurofibromin, an inactivator of proto-oncogene Ras. However, to our knowledge, only three cases of ependymomas with NF1 have been reported in the literature. The authors present a case of NF1 patient with a spinal cord ependymoma. She was referred for about half a year history of increasing numbness that progressed from her fingers to her entire body above the bellybutton. Magnetic resonance imaging revealed a relative-demarcated, heterogeneously enhanced mass lesion accompanied by perifocal edema in C5-7 level, a left-sided T11 spinous process heterogeneously enhanced mass in soft tissue, intervertebral disk hernia in L2-5 level, and widespread punctum enhancing lesion in her scalp and in T11-L5 level. The patient underwent C5-7 laminectomies and total excision of the tumor under operative microscope, and intraoperative ultrasonography and physiological monitoring were used during the surgery. Histopathologically, her tumor was found to be a ependymoma without malignant features (grade II in the World Health Organization classification). Therefore, no adjuvant therapy was applied. Following the operation, the patient showed an uneventful clinical recovery with no evidence of tumor recurrence after one year of follow-up.

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Section: Discussionmentioning

confidence: 88%

Spinal Cord Ependymoma Associated with Neurofibromatosis 1 : Case Report and Review of the Literature

Cheng

Shan

Feng

et al. 2014

J Korean Neurosurg Soc

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“…In the cerebrum, tanycytes are most commonly located along the lateral wall of the third ventricle. In the spinal cord, however, they surround the central canal and radiate towards the grey matter [5–7]. Published reports indicate that most adult ependymomas are located in the spinal cord in an extra- or intramedullary location [8].…”

Section: Discussionmentioning

confidence: 99%

Tanycytic Ependymoma: A Challenging Histological Diagnosis

Krisht

Schmidt

2013

Case Reports in Neurological Medicine

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Tanycytic ependymoma is a rare form of ependymoma that usually arises in the intramedullary spine. It has a unique histology emphasized by the inconspicuous ependymal pattern of cells and close resemblance to schwannoma and astrocytoma. The authors report a 50-year-old man with a cervical tanycytic ependymoma that was initially thought to be a schwannoma. The frozen histology section showed spindle cells with oval and elongated nuclei with occasional hemosiderin deposits present suggesting a preliminary diagnosis of schwannoma. Immunohistochemical staining of the permanent section revealed strong immunoreactivity for glial fibrillary acidic protein with intermittent S-100 positivity, confirming that the tumor was a tanycytic ependymoma. This underlines the challenges involved in making an accurate diagnosis and demonstrates that careful and detailed histological inspection with immunohistochemical stains and ultrastructural microscopy may be necessary to distinguish tanycytic ependymoma from other neoplasms.

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“…10 Morphologic features, such as a biphasic pattern (cellular Antoni A area and hypocellular Antoni B area) in schwannoma and whorl formation and psammoma bodies in meningioma, are helpful for the differential diagnosis; however, immunohistochemical examinations are essential for making a correct diagnosis. 11 Schwannoma is invariably S-100 protein positive and meningioma is epithelial membrane antigen positive, whereas both markers are absent in nodular fasciitis. In addition, tanycytic ependymoma 11 -13 and myxopapillary ependymoma 14 are composed of cellular proliferation of spindle cells with a myxoid area; however, both types of ependymomas show strong immunohistochemical reactions for S-100 protein.…”

Section: Discussionmentioning

confidence: 99%

Extradural Nodular Fasciitis Arising in the Spinal Canal

Kubota

Okada

Maeda

et al. 2012

Spine

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This report presents a very rare case of extradural nodular fasciitis arising in the lumbar spinal canal, which could have been misinterpreted as a malignant tumor such as extraskeletal Ewing sarcoma/primitive neuroectodermal tumor because of its rapid growth and absence of distinguishing radiologic features. A detailed histopathologic examination including immunohistochemistry is important for the correct diagnosis.

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Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2

Cited by 17 publications

References 5 publications

Spinal Cord Ependymoma Associated with Neurofibromatosis 1 : Case Report and Review of the Literature

Spinal Cord Ependymoma Associated with Neurofibromatosis 1 : Case Report and Review of the Literature

Tanycytic Ependymoma: A Challenging Histological Diagnosis

Extradural Nodular Fasciitis Arising in the Spinal Canal

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