Spinal hyperbaric prilocaine vs. mepivacaine in perianal outpatient surgery

Gebhardt, Volker; Beilstein, Benedikt; Herold, Alexander; Weiß, Christel; Fanelli, Guido; Dusch, M.; Schmittner, Marc D.

doi:10.2478/s11536-013-0336-5

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Previous study done by Gebhardt et al suggested that hyperbaric prilocaine had faster recovery from spinal anaesthesia when compared with mepivacaine. (Gebhardt et al, 2014) Figure 11: Bar graph depicting the association between the awareness of effective use of hyperbaric prilocaine and age groups. X axis -age in years; Y axis-number of students with their responses.…”

Section: Methodsmentioning

confidence: 99%

Awareness About Hyperbaric Prilocaine Among Dental Students

Prashaanthi¹

2020

Biosci. Biotech. Res. Comm

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Hyperbaric formulation of local anesthetic solutions have some advantages over plain solutions. The hyperbaric solutions are used in various fields of medicine due to their properties. The aim of this study was to assess the awareness about hyperbaric prilocaine among dental students.This study included 150 dental students in a dental hospital during the month of December 2019. Pre tested questionnaire was distributed among the students through an online link. Data was tabulated and results were obtained.Descriptive and chi square statistics were performed.Out of 150 patients, 6 students (44%) were under 18-20 years and 84 students (56%) were under 21-25 years age groups. Out of 150 students ,87 students (58%) were males and 63 students (42%) were females. On analysing the awareness of hyperbaric prilocaine among students, 88% had known about hyperbaric oxygen and 12% were not aware about hyperbaric prilocaine. There was a significant association between age groups and awareness among dental students (p<0.05) while no statistically significant was found between gender and awareness among dental students (p>0.05). Within the limitations of the present study, the awareness about the uses and properties of hyperbaric prilocaine was moderate.

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Section: Methodsmentioning

confidence: 99%

Awareness About Hyperbaric Prilocaine Among Dental Students

Prashaanthi¹

2020

Biosci. Biotech. Res. Comm

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“…Since 2009, a new and stable formulation of 2% hyperbaric prilocaine for intrathecal administration has been developed and increasingly used in day-case surgery setting. The ever-growing use of this drug led to several studies deining the optimal doses for diferent types of surgery (Gebhardt et al 2013(Gebhardt et al , 2014Kaban et al 2014;Guntz et al 2014). Metabolism of prilocaine and particularly its downstream metabolite o-toluidine was also studied (Fig.…”

Section: Introductionmentioning

confidence: 99%

Quantification of systemic o-toluidine after intrathecal administration of hyperbaric prilocaine in humans: a prospective cohort study

et al. 2021

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Optimal local anesthetic regimen for saddle block in ambulatory anorectal surgery: an evidence-based systematic review

Yung

Abdallah

Todaro

et al. 2020

Reg Anesth Pain Med

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BackgroundAmbulatory anorectal surgery requires an anesthetic of short duration but profound depth. Saddle block anesthesia (SBA) can provide dense sacral anesthesia with minimal motor blockade, but the ideal local anesthetic agent remains undefined. This systematic review aims to identify the optimal SBA regimen for ambulatory anorectal surgery.MethodsWe sought randomized trials examining SBA for ambulatory anorectal surgery and stratified patients into four subgroups according to local anesthetic type and dose: (1) longer acting, higher dose; (2) longer acting, lower dose; (3) shorter acting, higher dose; and (4) shorter acting, lower dose. Longer acting agents included bupivacaine and levobupivacaine; shorter acting agents included chloroprocaine, mepivacaine, and prilocaine. Lower dose was defined as ≤5 mg and ≤20 mg for longer and shorter acting local anesthetics, respectively. The primary outcome was time to discharge; secondary outcomes included times to sensory and motor block regression, urine voiding, and ambulation, as well as block success.ResultsA total of 11 trials (1063 patients) were included. Overall study quality and reporting consistency was poor. Doses ranged from 1.5–7.5 mg to 3–30 mg of longer and shorter acting local anesthetics, respectively. Hyperbaric local anesthetics were used in eight trials (953 patients, 86%). The median time to discharge appeared similar across all subgroups with an overall time of 182 (IQR 102) min. The use of long-acting, lower dose regimens was associated with a faster median time to motor block regression. Block success approached 99% among all trials.ConclusionsThere is presently insufficient qualitative and quantitative evidence to identify an optimal SBA regimen for ambulatory anorectal surgery. Nonetheless, we found that doses as low as 1.5 and 3 mg of longer and shorter acting hyperbaric local anesthetics, respectively, can achieve effective and reliable SBA with timely hospital discharge. Despite similar discharge times, longer acting, lower dose local anesthetics may produce faster motor block regression following SBA for ambulatory anorectal surgery.

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Spinal hyperbaric prilocaine vs. mepivacaine in perianal outpatient surgery

Abstract: Abstract

Cited by 3 publications

References 30 publications

Awareness About Hyperbaric Prilocaine Among Dental Students

Awareness About Hyperbaric Prilocaine Among Dental Students

Quantification of systemic o-toluidine after intrathecal administration of hyperbaric prilocaine in humans: a prospective cohort study

Optimal local anesthetic regimen for saddle block in ambulatory anorectal surgery: an evidence-based systematic review

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