Spinal Metastasis of Cerebral Glioblastoma with Genetic Profile: Case Report and Review of Literature

Shaaban, Ahmed A.; R, Arun Babu; Elbadry, Rasha; Haddad, Rizq; Al-Bozom, Issam; Ayyad, Ali; Belkhair, Sirajeddin

doi:10.1016/j.wneu.2020.07.163

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…LMD can mimic infectious/inflammatory meningitis, while the focal form, depicting spinal pseudo-tumoral lesions, can mimic dural-based tumors [ 6 , 7 ]. Spinal metastases are usually multifocal, multiplanar lesions displaying a predilection for the thoracic region, followed by the lumbar and cervical segments [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Primary malignant central nervous system (CNS) tumors represent 2% of all types of cancer, of which more than 50% are glioblastomas (GBMs) [ 1 , 2 ]. The leptomeningeal dissemination (LMD) of GBM is poorly documented, and insufficient data exist to evaluate its incidence and prevalence [ 3 ]. A few studies suggest that there may be multiple risk factors for dissemination, including surgical resection, surgical opening of the ventricles, ventricular invasion, and immunosuppression [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Leptomeningeal Dissemination Complicated With Acute Tetraplegia From a Supratentorial Multicentric Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma: A Case Report

Visarion,

Cale,

Miron

et al. 2024

Cureus

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Glioblastoma (GBM) is a major concern for neurosurgeons and oncologists, being a malignant tumor with a high recurrence rate and reduced survival. Leptomeningeal dissemination (LMD) of GBM is rare and difficult to diagnose due to the low rate of cellular detection in the cerebrospinal fluid and clinical and imaging similarities with fungal and tuberculous meningitis. We report the case of a 25-year-old female patient suffering from multicentric GBM who developed hydrocephalus and extensive LMD three months after surgery for a left frontal parafalcine cerebral GBM isocitrate dehydrogenase (IDH)-wildtype.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leptomeningeal Dissemination Complicated With Acute Tetraplegia From a Supratentorial Multicentric Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma: A Case Report

Visarion,

Cale,

Miron

et al. 2024

Cureus

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“…Previously reported therapeutic options include surgical decompression, chemotherapy, and radiotherapy of the craniospinal axis (25 to 40 Gy) for spinal metastases of GBM ( 11 ). Some authors suggest that treatment for spinal metastases of GBM was only for pain relief and neurologic deficits but exerted no effect on the overall outcome ( 21 , 22 ). Chemoradiotherapy is the typical treatment method after diagnosis of spinal metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Chemoradiotherapy is the typical treatment method after diagnosis of spinal metastasis. Surgery can be performed for focal lesions, but chemoradiotherapy is the only option for diffuse or leptomeningeal disease ( 21 , 22 ). The anatomical location and the infiltrative nature of GBM make total resection of the tumor mass virtually impossible ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

et al. 2022

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BackgroundGlioblastoma multiforme (GBM) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric (MC) gliomas involve lesions widely separated in space or time, and MC gliomas involving supra- and infratentorial brain regions are rare. In most cases, the infratentorial lesion is seen after surgical manipulation or radiation therapy; it is typically located in the cerebellum or the cervical region, manifesting as metastasis originating from the brain. Besides, venous thromboembolism in brain tumors is usually seen after craniotomy.Case PresentationWe present an uncommon adult case of symptomatic H3K27M-mutant MC glioblastoma simultaneously present in the brain, fourth ventricle, and cervical and lumbar spinal cord regions accompanied by acute pulmonary artery embolism in an adult woman who had not undergone previous therapeutic interventions. We also review the literature on this interesting presentation.ConclusionOur report highlights that clinicians should be alert to the potential alarming presentation of GBM. The incidence of spinal metastasis of cerebral GBM is increasing. Patients with a prior diagnosis of GBM with or without any new onset in the spinal cord should undergo an early MRI of the spinal cord to confirm the diagnosis at an early stage. While management of GBM remains controversial, more research is needed to explore molecular features of GBM further and develop novel targeted therapies for these patients.

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“…A ocorrência de metástase em medula espinhal a partir de um glioblastoma de origem cerebral é considerada extremamente rara. Além disso, recorrências de glioblastomas na medula também apresentam tal padrão de raridade (BATASH et al, 2017;SHAABAN et al, 2020).…”

Section: Introductionunclassified

Glioblastoma recidivante em medula espinal: um relato de caso / Recurrent glioblastoma in spinal cord: a case report

Lucino¹,

Reis²,

Silva³

et al. 2021

BJDV

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Spinal Metastasis of Cerebral Glioblastoma with Genetic Profile: Case Report and Review of Literature

Cited by 7 publications

References 20 publications

Leptomeningeal Dissemination Complicated With Acute Tetraplegia From a Supratentorial Multicentric Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma: A Case Report

Leptomeningeal Dissemination Complicated With Acute Tetraplegia From a Supratentorial Multicentric Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma: A Case Report

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

Glioblastoma recidivante em medula espinal: um relato de caso / Recurrent glioblastoma in spinal cord: a case report

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