Spinal neurotoxicity and tolerance after repeated intrathecal administration of YM 872, an AMPA receptor antagonist, in rats

Abstract

Administration of YM 872 (1 micro g) once a day for 30 days did not induce any tolerance and caused no histological changes in the spinal cord.

Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats

“…In our study, changes compatible to chronic nonspecific inflammation at the tip of the catheter location were observed in all the animals. This finding has been documented in previous reports 22–26,41–43 . The evidence of chronic nonspecific inflammation has been associated with the presence of the catheter rather than a possible neurotoxic effect.…”

The analgesic effect of diclofenac sodium administered via the epidural route in an experimental visceral pain model

“…[15] Therefore, many studies have been performed on the intrathecal or epidural use of NSAID. [1,[12][13][14]17] In a previous study, diclofenac sodium administered via subcutaneous, intracerebroventricular, and intrathecal routes was shown to lead to dose-dependent inhibition in a visceral pain model. [18] Björkman also studied the localizations of central antinociceptive effects of diclofenac sodium.…”