Spinal xanthogranuloma in a child: Case report

Shimosawa, S; Tohyama, Kiyonori; Shibayama, Mikine; Takeuchi, H; Hirota, Toshiyuki

doi:10.1016/0090-3019(93)90092-f

Cited by 29 publications

(32 citation statements)

References 12 publications

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“…16,26,30,37 These cases were positive for CD68 and negative for CD1a, or showed Touton giant cells. The location was intracranial in 2 cases, 16,30 and intraspinal in the other 2 cases.…”

Section: Discussionmentioning

confidence: 99%

“…The location was intracranial in 2 cases, 16,30 and intraspinal in the other 2 cases. 26,37 One case was in an infant, 37 and the other 3 cases were in adults. 16,26,37 Among the 42 cases of isolated intracraniospinal nonLCHs (reported as JXG, fibrous xanthoma, xanthoma, fibroxanthoma, and XG) including our case (Table 1), 18 cases (43%) were dural-based lesions.…”

Section: Discussionmentioning

confidence: 99%

“…26,37 One case was in an infant, 37 and the other 3 cases were in adults. 16,26,37 Among the 42 cases of isolated intracraniospinal nonLCHs (reported as JXG, fibrous xanthoma, xanthoma, fibroxanthoma, and XG) including our case (Table 1), 18 cases (43%) were dural-based lesions. 1,2,5,9,11,16,21,22,[25][26][27][28]30,32,35,37,38 Eleven of these 18 cases were intracranial 1,2,5,9,16,21,27,28,30,38 and the other 7 were spinal.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report

Miyake¹,

Ito²,

Tanaka

et al. 2015

PED

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The authors report the case of a large left occipital mass lesion in an 8-month-old boy who presented with seizure. Neuroimaging demonstrated an approximately 5-cm extraaxial tumor, and the patient underwent partial resection. The tumor was strongly attached to the tentorium and falx. In the postoperative course the residual lesion regressed spontaneously, and after 5 years only a slight residual tumor remained along the tentorium. Histopathological examination of the tumor revealed non-Langerhans cell histiocytosis (non-LCH). However, the tumor was not diagnosed as juvenile xanthogranuloma (JXG) because it lacked Touton giant cells. Hence, the authors described this lesion as a fibroxanthogranuloma. Most intracraniospinal non-LCHs have been reported as JXG; however, several cases of xanthomatous tumors with histopathological features resembling those of JXG have been described as fibrous xanthoma, xanthoma, fibroxanthoma, and xanthogranuloma. Among JXG and the xanthomatous tumors, a review of the literature revealed several cases of dural-based tumors; these dural-based tumors have had favorable courses, including the case described in this report. In addition, the patient in the present case experienced spontaneous regression of the residual tumor. The authors report this unique case and review the literature on isolated intracraniospinal non-LCHs, especially in cases of dural-based lesion.

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“…16,26,30,37 These cases were positive for CD68 and negative for CD1a, or showed Touton giant cells. The location was intracranial in 2 cases, 16,30 and intraspinal in the other 2 cases.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report

Miyake¹,

Ito²,

Tanaka

et al. 2015

PED

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“…And other reported involving organs include the oropharynx, heart, lung, liver, spleen, adrenals, muscles, subcutaneous tissues, and the central nervous system, but the involvement of spine is extremely rare [2,11,15]. We could find only four such cases reported in English [8,9,15,16] so far, and no report of a xanthogranuloma involving C1 and C2 (Table 1). The present case, to the best of our knowledge, is the first solitary JXG case involving the upper cervical spine, which originated from the C2 nerve root.…”

Section: Discussionmentioning

confidence: 50%

Solitary juvenile xanthogranuloma in the upper cervical spine: case report and review of the literatures

Cao

Yang

et al. 2008

Eur Spine J

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Solitary juvenile xanthogranuloma (JXG) in the spinal column is extremely rare and there has been no report of such a lesion involving C1 and C2 in English literature so far. Here, we report and characterize the first case of xanthogranuloma of the upper cervical spine. This case report draws attention to the fact that solitary xanthogranuloma should be considered among possible diagnoses of spinal tumor in children and young adults. An 18-year-old female patient presented to the hospital with intermittent pain in the right side of the neck. MRI studies revealed a huge soft tissue mass to the right side of the C1 and C2 vertebras, and osseous destruction can be found in the cervical spine CT scan. Complete surgical removal of the tumor and occipital-cervical instrumentation with autogenous bone graft were performed with no complications. The patient was free of pain immediately after the surgery with intact neurological functions. Follow-up MRI 6 and 12 months after the surgery showed no residue or recurrence of the tumor. Our report and the literature review indicate that isolated JXG does not show any predilections of localization inside the central nervous system. So a solitary xanthogranuloma should be considered among possible diagnoses of spinal tumor in susceptible patients. Localized JXG shows isointense signals in MRI and enhances homogeneously with gadolinium. Immunohistochemical studies can ensure the diagnosis. Whenever possible, total surgical removal alone seems to be curative.

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“…Orbital and skull base involvement is common, though xanthogranuloma in a colloid cyst has been described before (13). Isolated spinal involvement is extremely rare, and to the best of our knowledge, there are only 11 reported cases in the English literature, and third in the subaxial cervical spine (1,3,5,6,8,14,15,(18)(19)(20).…”

Section: Konar S Et Al: Solitary Juvenile Xanthogranuloma In Cervicamentioning

confidence: 99%

Solitary juvenile xanthogranuloma in cervical spine: case report and review of literature

Konar

Pandey²,

Yasha³

2013

Turkish Neurosurgery

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Solitary juvenile xanthogranuloma (JXG) in the spinal column is extremely rare. Here, we report and characterize the case of xanthogranuloma of the upper cervical spine. A 18-year-old male presented with neck pain for 3 months, along with progressive quadriparesis and sensory loss of 2 months duration with urinary retention. Motor examination revealed spastic quadriparesis with power of 2/5 in all the 4 limbs. Magnetic Resonance Imaging (MRI) spine with contrast showed a dorsally placed intradural extramedullary lesion at the level of C2-C4 vertebral body. The lesion, measuring 2.9x1.7x1.4 cm, was isointense on T1WI, hypointense on T2WI, and enhanced homogenously on contrast. He underwent an emergency C2-C4 laminectomy and complete excision of the lesion. At 3-month follow-up, he was asymptomatic except for mild neck pain. MRI scan of the cervical spine done at follow-up, revealed complete excision of tumor without any residual lesion. Histopathological examination of the mass revealed a polymorphous population of sheets of bloated pale foamy histiocytes (xanthoma cells), numerous admixed mature lymphocytes and several Touton giant cells. The cells were positive for CD68, a histiocytic marker, and negative for CD1a (excludes LCH) and S-100 (excludes RDD). KeywOrds: Juvenile xanthogranuloma, Cervical spine, MRI, Complete resection ÖZOmurgada soliter jüvenil ksantogranülom çok nadirdir. Burada üst servikal omurgada bir ksantogranülom olgusunu bildiriyoruz. 18 yaşında bir erkek 3 aydır boyun ağrısı, 2 aydır progresif kuadriparezi ve duyu kaybı ile üriner retansiyonla geldi. Motor inceleme 4 uzuvda 2/5 güçle spastik kuadriparezi gösterdi. Omurganın kontrastlı Manyetik Rezonans Görüntülemesi (MRG) C2-C4 vertebral cisim seviyesinde dorsal yerleşimli bir intradural ekstramedüller lezyon ortaya koydu. 2,9x1,7x1,4 cm boyutlarında olan lezyon T1WI ile izointens, T2WI ile hipointens ve kontrast ile homojen tutulum göstermekteydi. Acil C2-C4 laminektomi ve lezyonun tam eksizyonu yapıldı. 3 aylık takipte hafif boyun ağrısı dışında semptom yoktu. Takipte yapılan servikal omurga MRG taraması herhangi bir rezidüel lezyon olmadan tümörün tam eksizyonunu gösterdi. Kitlenin histopatolojik incelemesi şiş ve soluk köpüklü histiosit tabakalarının (ksantoma hücreleri) polimorfik bir popülasyonunu, araya karışmış çok sayıda matür lenfositi ve birkaç Touton dev hücresini gösterdi. Hücreler bir histiositik belirteç olan CD68 için pozitifti ve CD1a (LCH ekarte eder) ve S-100 (RDD ekarte eder) için negatifti.

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Spinal xanthogranuloma in a child: Case report

Cited by 29 publications

References 12 publications

Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report

Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report

Solitary juvenile xanthogranuloma in the upper cervical spine: case report and review of the literatures

Solitary juvenile xanthogranuloma in cervical spine: case report and review of literature

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