Spindle-Cell and Pleomorphic Neoplasms of the Skin

Ng, Silvis; Pe, Swanson; Jc, Manivel; Vn, Kaye; Mr, Wick

doi:10.1097/00000372-198802000-00002

Cited by 85 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 They found each of the immunostains decorated all the neoplasms; however, MNF showed more intense labeling than the other markers. 19 Most of these studies used vimentin and only 1 or 2 cytokeratins within the IHC panel. The spindle cell squamous carcinomas showed cytokeratin and vimentin positivity, whereas other nonsquamous neoplasms were cytokeratin negative and vimentin positive.…”

Section: Discussionmentioning

confidence: 95%

“…18 The final study examined 2 cases of spindle cell squamous carcinoma and found both to stain with AE1/AE3. 19 Finally, a group of keratin immunohistochemical stains consisting of CAM 5.2, AE1/AE3, and MNF116 (keratins 5, 6, 8, 17, and 19) were tested in 5 poorly differentiated spindle cell squamous cell carcinomas. 19 They found each of the immunostains decorated all the neoplasms; however, MNF showed more intense labeling than the other markers.…”

Section: Discussionmentioning

confidence: 99%

“…19 Finally, a group of keratin immunohistochemical stains consisting of CAM 5.2, AE1/AE3, and MNF116 (keratins 5, 6, 8, 17, and 19) were tested in 5 poorly differentiated spindle cell squamous cell carcinomas. 19 They found each of the immunostains decorated all the neoplasms; however, MNF showed more intense labeling than the other markers. 19 Most of these studies used vimentin and only 1 or 2 cytokeratins within the IHC panel.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Distinction of Cutaneous Spindle Cell Carcinoma

Morgan¹,

Purohit²,

Anglin³

2008

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Cutaneous spindle cell squamous carcinoma is an uncommon variant of squamous cell carcinoma in which keratinocytes infiltrate the dermis as single cells with elongated nuclei rather than as cohesive nests or islands, and signs of keratinization of conventional squamous cell carcinoma are insubstantial or nonexistent. Spindle cell carcinoma must be distinguished from spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, atypical fibroxanthoma (AFX), and scar. In instances when there is no definitive evidence of squamous differentiation, immunohistochemical studies may confer diagnostic discrimination. Twenty-four cases consisting of 12 spindle cell squamous cell carcinomas, 3 AFXs, 3 leiomyosarcomas, 3 desmoplastic melanomas, and 3 scars were evaluated with a battery of immunohistochemical stains, with the specificity and sensitivity of each marker calculated. The immunohistochemical battery consisted of S-100, desmin, CD68, and smooth muscle actin and cytokeratins P KER (keratins predominantly of molecular weight 56 and 69 kd) and low-molecular weight keratin (CAM 5.2), AE1/AE3, p63, and 34 beta E12 (CK903). Spindle cell squamous carcinomas were negative for S-100, CD68, smooth muscle actin, and desmin with the exception of 2 cases with weak staining for smooth muscle actin. 34 beta E12 provided positive results for each spindle cell squamous carcinoma. The other cytokeratin stains were less sensitive for spindle cell squamous carcinoma than 34 beta E12. The final immunohistochemical results were as follows: 34 beta E12 (12/12, 100%), p63 (10/12, 80%), AE1/AE3 (8/12, 67%), low-molecular weight keratin (7/12, 58%), and P KER (4/12, 33%). The 3 AFXs were positive for CD68 and negative for all other stains, whereas the 3 leiomyosarcomas stained positively for desmin and smooth muscle actin and negatively for all other stains. The 3 melanomas stained positively for S-100 and negatively for all other immunohistochemistry. The scars were negative for all stains. In conclusion, our study of 34 beta E12 proved most promising in distinguishing spindle cell squamous carcinoma from the histologic mimickers, AFX, spindle cell melanoma, scar, and leiomyosarcoma.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical Distinction of Cutaneous Spindle Cell Carcinoma

Morgan¹,

Purohit²,

Anglin³

2008

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…The present tumor is carcinoma. Atypical fibroxanthoma and desmoplastic melanoma was excluded because the present tumor expressed various CKs and did not express HMB45, Melan-A, SOX10, MITF; [3][4][5][6][7][8][9][10] the specificity of S100 protein is low, [3][4][5][6][7][8][9][10] the possibility of desmoplastic melanoma is quite unlikely. Because the present tumor expressed CKs, it is carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9][10] These two variants of skin SCC lack keratinization and intercellular bridge, thus causing diagnostic problems. [1][2][3][4][5][6][7][8][9][10] The author herein reports a case of desmoplastic SCC composed predominantly of spindle cells.…”

Section: Introductionmentioning

confidence: 99%

Desmoplastic spindle cell squamous cell carcinoma of skin

Terada

2016

CRCP

View full text Add to dashboard Cite

Desmoplastic squamous cell carcinoma (SCC) and spindle cell SCC is very rare in skin. An 86-year-old woman presented a skin tumor of face. The tumor measured 1.8 cm × 1.6 cm × 0.6 cm. An excisional biopsy was performed. Histologically, malignant spindle cells with hyperchromatic nuclei and nucleoli were seen to proliferate together with marked solar elastosis and desmoplasia. Mitotic figures were scattered. Immunohistochemically, the malignant cells were positive for pancytokeratin AE1/3, pancytokeratin WSS, cytokeratin (CK) 5/6, CK34BE12, CK14, vimentin, S100 protein, α-smooth muscle actin, p53, p63, and Ki-67 (labeling = 70%). They were negative for EMA, pancytokeratin CAM5.2, CK7, CK8, CK18, CK19, CK20, desmin, HMB45, Melan-A, SOX10, MITF, myoglobin, CEA, CA19-9 and CD34. The lesion recurred two times and showed neck lymph node metastasis during the following 2 years. The patient died of other diseases 3 years after the first presentation.

show abstract