Spindle Cell Carcinoma of the Oral Cavity and Oropharynx: Factors Affecting Outcome

Su, Hsing‐Hao; Chu, Sau-Tung; Hou, Yu‐Yi; Chang, Kuo-Ting; Chen, Chia‐Jung

doi:10.1016/s1726-4901(09)70312-0

Cited by 110 publications

(146 citation statements)

References 11 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…Sarcomatoid (spindle cell) carcinomas of the head and neck are unusual variants of squamous carcinoma commonly reported in the larynx but also described in other mucosal sites such as gingiva, tongue, hypopharynx and nasal cavity [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. These tumors have now been proved to be monoclonal, evolving from conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Viswanathan

Rahman

Pallavi

et al. 2010

Head and Neck Pathol

170

177

View full text Add to dashboard Cite

Sarcomatoid carcinomas are biphasic tumors proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. This study evaluates their clinicopathologic characteristics in head and neck mucosal sites and the problems in distinguishing them from other spindle cell tumors. A total of 103 cases with a confirmed diagnosis of sarcomatoid carcinoma accessioned in the pathology department of a tertiary referral cancer centre over a period of 7 years (2004)(2005)(2006)(2007)(2008)(2009)(2010) were studied. An algorithm used for their diagnosis is presented. Ages of the patients were 22-90 years (median 53 years), and male:female ratio was 3.7:1. Site distribution was oral cavity (n = 65, 63.1%), larynx (18, 17.5%), oropharynx/hypopharynx (12, 10.7%), maxilla (6, 5.8%) and metastatic nodes (2, 1.9%). A large number of patients (95%) presented with a mass lesion of less than 1 year duration. Histopathologically, epithelial differentiation was evident on morphology in 48 (46.6%) cases, only on IHC in 34 (33%) cases, and in 21 (20.4%) no epithelial differentiation was seen. Typically, tumors were polypoidal (92, 89.3%) and ulcerated (95, 92.2%) with cells arranged predominantly in fascicles (59, 57.3%) or storiform pattern (17, 16.5%) amidst collagenous (50, 48.5%) or myxoid matrix (35, 34%). Anaplasia (2?/3?) and mitosis[10 per 10 HPF were noted in 96 (93.2%) cases. IHC was done in 82 cases; 55 (66.7%) showed positivity for epithelial markers with aberrant expression of mesenchymal markers in 43 (41.7%). Diagnosis of sarcomatoid squamous carcinoma is challenging because of overlapping histopathological features with other spindle cell tumors. Understanding their clinicopathologic characteristics facilitates their diagnosis and appropriate clinical management.

show abstract

Section: Introductionmentioning

confidence: 99%

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Viswanathan

Rahman

Pallavi

et al. 2010

Head and Neck Pathol

170

177

View full text Add to dashboard Cite

show abstract

“…The larynx is the most frequent site of development in the head and neck region. In the oral cavity, many cases of SPCC in the lips and tongue have been reported, but development of SPCC in the alveolar gingiva is relatively rare [4][5][6][7]. SPCC tends to occur more frequently in men and the onset age varies from the 20s to the 90s, with a reported association with cigarette smoking and alcohol consumption [2, 4-6, 8, 9].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Ellis et al [4] reported metastasis in 16 of 59 cases, with 11 occurrences in the cervical lymph node, and Su et al [5] found a metastasis rate of 33.3%. Survival rates for SPCC of 36% [4] and 27.5% [5] have been reported. SPCC is treated similarly to SCC through surgery alone or in combination with radiotherapy, but high recurrence rates after treatment of 12 of 59 cases [4] and 73.3% [5] have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Survival rates for SPCC of 36% [4] and 27.5% [5] have been reported. SPCC is treated similarly to SCC through surgery alone or in combination with radiotherapy, but high recurrence rates after treatment of 12 of 59 cases [4] and 73.3% [5] have been reported.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A case of oral multiple primary cancer including Spindle Cell Carcinoma

Kato

Nomura

Matsumura

et al. 2010

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Spindle Cell Carcinoma (SPCC) is a relatively rare tumour that is classified as a subtype of squamous cell carcinoma (SCC). Histologically, SPCC is composed of a SCC region and epithelium-derived spindle cells with mesenchymal differentiation. We encountered an interesting case of multiple cancer including SPCC. A histopathologically atypical papillary lesion was found 13 years before our initial examination. Multiple verrucous leukoplakia later developed in the oral mucosa, for which an oral vitamin A derivative (a retinoid) was intermittently administered. Multiple cancer including SPCC subsequently developed in the lower gingiva. We investigated the case histologically and immunohistologically based on the concept of field cancerization.

show abstract

TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target

Silva

Alaoui‐Jamali

Soares

et al. 2013

Cancer

View full text Add to dashboard Cite

BACKGROUND: Locoregional recurrence and distant metastases are ominous events in patients with advanced oral squamous cell carcinoma (OSCC). The objective of this study was to identify functional biomarkers that are predictive of OSCC progression to metastasis. METHODS: The expression profile of a network of epithelial-mesenchymal transition (EMT) genes was investigated in a large cohort of patients with progressive OSCC using a complimentary DNA microarray platform coupled to quantitative reverse transcriptase-polymerase chain reaction and immunohistochemical analyses. Therapeutic potential was investigated in vitro and in vivo using an orthotopic mouse model of metastatic OSCC growing in the tongue microenvironment. RESULTS: Among deregulated EMT genes, the Twist-related protein 1 (TWIST1) transcription factor and several of its regulated genes were significantly overexpressed across advanced stages of OSCC. This result was corroborated by the clinical observation that Twist1 up-regulation predicted the occurrence of lymph node and lung metastases as well as poor patient survival. In support of Twist1 as a driver of OSCC progression, the up-regulation of Twist1 was observed in cells isolated from patients with metastatic OSCC. The inhibition of Twist1 in these metastatic cells induced a potent inhibition of cell invasiveness in vitro as well as progression in vivo. CONCLUSIONS: The current results provide evidence for the prognostic value and therapeutic potential of a network of Twist genes in patients with advanced OSCC. Cancer 2014;120:352-62.

show abstract

Spindle Cell Carcinoma of the Oral Cavity and Oropharynx: Factors Affecting Outcome

Cited by 110 publications

References 11 publications

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

A case of oral multiple primary cancer including Spindle Cell Carcinoma

TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target

Contact Info

Product

Resources

About