Spindle cell carcinoma of the breast – A case report –

Nozoe, Emiko; Nozoe, Tetsuo; Tanaka, Junko; Ohga, Takefumi; Fujita, Akio; Sueishi, Katsuo

doi:10.2152/jmi.67.365

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Other antibodies ER, PgR and HER2 are generally negative, resembling normalised metaplastic carcinoma. As in our case, Rekhi et al [ 17 ], Nozoe et al [ 18 ], Rito et al [ 19 ] and others also found by immunohistochemical examination that FLMCa did not express estrogen receptors, progesterone receptors, and HER2 receptors, but mainly vimentin and basal cytokeratin. In addition, immunohistochemical expression of AE1/3 and CAM5.2 was also observed, and positive expression of epithelial and mesenchymal markers in these cells may be considered indicative of the "epithelial-mesenchymal" transformation observed in these tumors.…”

Section: Discussionsupporting

confidence: 85%

Fibromatosis-like metaplastic carcinoma of the breast: Two case reports

Bao¹,

Zhou²,

Luo³

et al. 2023

World J Clin Cases

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BACKGROUND Fibromatosis-like metaplastic carcinoma is classified as a rare type of metaplastic carcinoma of the breast by the 2012 WHO pathological and genetic classification criteria for breast tumors, which takes hyperplastic spindle cells as the main component and is often misdiagnosed as benign stromal proliferative lesions or benign mesenchymal tumors of the breast because of its mild morphology. Here, we collected the clinical data of 2 cases of fibromatosis-like metaplastic carcinoma of the breast and performed pathomorphological observation and immunohistochemical staining of the surgically resected specimens. According to the clinical features, imaging features, immunophenotype, diagnosis and differential diagnosis of 2 cases of fibromatosis-like metaplastic carcinoma of the breast, it was further differentiated. CASE SUMMARY Case 1: A 56-year-old postmenopausal female was admitted due to "right breast mass for over 1 year and local ulceration for over 1 mo". Physical examination showed a mass with a diameter of 4.5 cm × 5.5 cm palpable at 2.5 cm from the nipple at 1 o'clock in the right breast. The skin on the surface of the mass ruptured about 3 cm, with a small amount of exudation and bleeding, less clear boundary, hard texture, fair activity, without obvious tenderness. No obvious abnormality was palpable in the left breast. No enlarged lymph nodes were palpable in the bilateral axillae and bilateral supraclavicular region. After removing the mass tissue, it was promptly sent to the pathology department for examination. Case 2: Female, 52-years-old, premenopausal, admitted due to "right breast mass for more than 3 mo". Physical examination showed a 4.0 cm × 4.0 cm diameter mass palpable at 2.0 cm of the nipple in the lower outer 7 o'clock direction of the right breast, with less clear boundary, hard texture, fair activity, no significant tenderness, no palpable significant abnormalities in the left breast, and no palpable enlarged lymph nodes in the bilateral axillae and bilateral supraclavicular region. The mass was resected and sent for pathological examination. Postoperative pathological examination revealed fibromatosis-like metaplastic carcinoma of the breast in both patient 1 and patient 2. No systemic therapy and local radiotherapy were performed after surgery, and no tumor recurrence or metastasis was observed. CONCLUSION Fibromatosis-like metaplastic carcinoma of the breast is a rare subtype of metaplastic carcinoma that is often misdiagnosed, and the diagnosis relies on medical history collection, complete sampling, and full use of immunohistochemical assessment. The risk of lymph node and distant metastasis is low, and the current treatment is based on complete surgical resection. The efficacy of systemic radiotherapy and chemotherapy is not clear.

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Section: Discussionsupporting

confidence: 85%

Fibromatosis-like metaplastic carcinoma of the breast: Two case reports

Bao¹,

Zhou²,

Luo³

et al. 2023

World J Clin Cases

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“…Finally, another pitfall is where the spindle cell component demonstrates loss of cohesion of the tumor cells and consequently mimics an angiosarcoma. This has been described in other body sites as pseudoangiosarcomatouscarcinoma and has also been reported in oral cavity SpCC [19]. Mitotic activity can vary, but averages more than one per high power field with a range from 0 to over 10.…”

Section: Spindle Cell Carcinomamentioning

confidence: 53%

Sarcomatoid Lesions of Head and Neck Region: A Diagnostic Dilemma

Samaddar

Chatterjee

Abhinandan³

et al. 2021

JPRI

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One challenging feature of head and neck pathology is that a dizzying array of sarcomatoid lesions occurs here ranging all the way from reactive to malignant and very aggressive. This makes accurate diagnosis critical. These lesions are quite diverse with great clinical and biological heterogeneity. Some are malignant while many others are benign or simply reactive in nature. For example; at mucosal sites, a well known lesion is spindle cell carcinoma (SpCC), which are overtly malignant, and the differential diagnosis then includes a number of different malignant spindle cell lesions. However, there are several benign or even non-neoplastic lesions that can sometimes be difficult to discern from SpCC, e.g. Nodular fasciitis, Proliferative myositis, Cellular schwannoma, Benign fibrous histiocytoma, Carcino sarcoma, Sarcomatoid melanoma. Fracture callus, etc. Aim of Study: There is a diagnostic challenge to the oral pathologists to differentiate dizzying array of sarcoma like lesions from other similar microscopic simulates ranging all the way from reactive to malignant and very aggressive. This article aims to review the sarcomatoid lesions of the head and neck region with emphasis on differential diagnosis histologically and immunohistochemicaly.

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Spindle cell carcinoma of the breast – A case report –

Cited by 2 publications

References 13 publications

Fibromatosis-like metaplastic carcinoma of the breast: Two case reports

Fibromatosis-like metaplastic carcinoma of the breast: Two case reports

Sarcomatoid Lesions of Head and Neck Region: A Diagnostic Dilemma

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