Spinnability of collagen as a biomimetic material: A review

Bazrafshan, Zahra; Stylios, George K

doi:10.1016/j.ijbiomac.2019.02.024

Cited by 86 publications

(55 citation statements)

References 117 publications

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“…However, chitosan and collagen hydrogels have been investigated in the search for more efficient chitosanbased hydrogel for use in medical and pharmaceutical technology. Collagen is the main structural protein in the extracellular space of some connective tissue [12]. It supports cell attachment in vertebrates, interacts with cells, and regulates cell migration, proliferation, and survival [13].…”

Section: Introductionmentioning

confidence: 99%

Integration of collagen into chitosan blend film composites: physicochemical property aspects for pharmaceutical materials

et al. 2020

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Chitosan and collagen-based hydrogel composites were successfully prepared at chitosan:collagen volume ratio of 1:1, 1:3, 1:5, and 1:10. The structural, thermal, morphological, swelling, mechanical characteristics were investigated, and in vitro degradation testing was conducted. Tetraethyl orthosilicate (TEOS) was used as a crosslinking agent between the chitosan and collagen chains. The NH group of both chitosan and collagen can form crosslinks with the OH groups of TEOS. XRD reported that no significant peak of crystallinity was observed during the integration of collagen into the chitosan film. The surface of the composite was rougher than that of the collagen. The composites were thermally stable up to 200 °C. The glass transition temperature slightly decreased in the presence of collagen. The tensile strength significantly decreased, while the elongation at break significantly increased, when collagen was integrated into the chitosan film. The collagen conferred strong swelling and rapid degradation on the composite. The chitosan/collagen composite films developed in this study have potential applications as pharmaceutical materials.

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Section: Introductionmentioning

confidence: 99%

Integration of collagen into chitosan blend film composites: physicochemical property aspects for pharmaceutical materials

et al. 2020

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“…It is commonly found in tendons, skin, bones and blood vessel walls. To date, researchers have recognized and categorized 29 types of collagen, among which type I collagen makes up 90% of the collagen present in the animal body [ 83 ]. Collagen possesses complex supramolecular structure.…”

Section: Biomaterials From Marine Organismsmentioning

confidence: 99%

Biomaterials from the sea: Future building blocks for biomedical applications

Wan

Qin

Chen

et al. 2021

Bioactive Materials

105

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Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in the present review. These materials are easily available and possess excellent biocompatibility, biodegradability and potent bioactive characteristics. Important applications of marine biomaterials include medical applications, antimicrobial agents, drug delivery agents, anticoagulants, rehabilitation of diseases such as cardiovascular diseases, bone diseases and diabetes, as well as comestible, cosmetic and industrial applications.

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“…One other constraint for this experiment is the solvent used for dissolving the polymer. In current electrospinning methods, common solvents for collagen include 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), 2,2,2-trifluoroethanol (TFE), or acids (tri-fluoro acetic acid (TFA), acetic acid, hydrochloric acid) [22,23]. These solvents could be toxic if cells are directly incorporated into the polymer-solvent solution.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning Live Cells Using Gelatin and Pullulan

et al. 2020

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Electrospinning is a scaffold production method that utilizes electric force to draw a polymer solution into nanometer-sized fibers. By optimizing the polymer and electrospinning parameters, a scaffold is created with the desired thickness, alignment, and pore size. Traditionally, cells and biological constitutes are implanted into the matrix of the three-dimensional scaffold following electrospinning. Our design simultaneously introduces cells into the scaffold during the electrospinning process at 8 kV. In this study, we achieved 90% viability of adipose tissue-derived stem cells through electrospinning.

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Spinnability of collagen as a biomimetic material: A review

Cited by 86 publications

References 117 publications

Integration of collagen into chitosan blend film composites: physicochemical property aspects for pharmaceutical materials

Integration of collagen into chitosan blend film composites: physicochemical property aspects for pharmaceutical materials

Biomaterials from the sea: Future building blocks for biomedical applications

Electrospinning Live Cells Using Gelatin and Pullulan

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