SPIO@SiO₂–Re@PEG nanoparticles as magneto-optical dual probes and sensitizers for photodynamic therapy

Abstract

A superparamagnetic iron oxide core and a photoluminescent rhenium complex embedded in a silica shell are the active components of a dual magneto-optical nanoprobe, also able to generate singlet oxygen upon irradiation.

Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging

“…In this context, chromophores that meet some important requirements, such as chemical- and photo-stability, large Stokes shifts or long lifetimes, would be desirable. 17 To meet this goal, phosphorescent transition metal complexes with a d 6 (Ru II , Re I , and Ir III ) or d 8 (Pt II ) electronic configuration 18 and, predominantly, lanthanide derivatives (Eu III , Tb III , and Yb III ) 15 b ,19 have been investigated for the preparation of emissive silica nanoparticles. Among them, Ir III compounds can be considered an interesting alternative to organic fluorophores, as they display, in addition to all the above mentioned properties, high quantum yields ( ϕ ) and an easy adjustment of the emission wavelength by controlling the coordination ligands.…”

Tuning Polyamidoamine Design To Increase Uptake and Efficacy of Ruthenium Complexes for Photodynamic Therapy

“…By considering the relatively short reaction time and the instantaneous interaction between DHN and 1 O 2 to produce Juglone, we can thus apply the steady-state approximation to the 1 O 2 intermediate species. Therefore, its formation rate coincides with its disappearance rate and can be related to the rate of DHN consumption, which is assumed to be first order in DHN, , as reported below (eq ). Thus, by considering that under the selected experimental conditions the absorbance at 297 nm ( A 297 ) can be exclusively ascribed to DHN, we can evaluate the rate constants ( k obs ) of the DHN photo-oxidation process by fitting the A 297 experimental data as follows (eq ): The first-order semilogarithmic plots for DHN photo-oxidation in the presence of the investigated sensitizers are shown in Figure ; i.e., the ln­( A t / A 0 ) values linearly decrease all over the monitored irradiation time, in agreement with pseudo-first-order kinetics for all the investigated sensitizers.…”

“…By considering the relatively short reaction time and the instantaneous interaction between DHN and 1 O 2 to produce Juglone, we can thus apply the steady-state approximation to the 1 O 2 intermediate species. Therefore, its formation rate coincides with its disappearance rate and can be related to the rate of DHN consumption, which is assumed to be first order in DHN, 46,59 as reported below (eq 2).…”

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

“…Maggioni and co-workers have developed a multifunctional nanocomposite consisting of a Fe 3 O 4 core and a compact silica shell functionalized with a luminescent rhenium(I) complex (234). 449 The nanocomposite is readily taken up by A549 cells and localized in the perinuclear region, effectively inducing cell death upon continuous irradiation.…”