Spiral Organisms in the Baboon Stomach

Curry, Alan; Jones, D.M.; Eldridge, J.

doi:10.1016/s0140-6736(87)93032-7

Cited by 48 publications

(13 citation statements)

References 3 publications

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“…Long, spiral-shaped bacteria have also been reported in the stomachs of baboons (Popio hamadryas). This was associated with gastritis by Mackie and O'Rourke (138) but not by others (34,35). Non-H. pylori helicobacters, without clarification about the species, have been described to be naturally present in the stomachs of up to 100% of cynomolgus monkeys from many different geographic regions (55,187).…”

Section: Bronsdon Et Al (24) Isolated and Described H Nemestrinae Fmentioning

confidence: 96%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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Section: Bronsdon Et Al (24) Isolated and Described H Nemestrinae Fmentioning

confidence: 96%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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“…Studies of the gastric mucosa of animals, however, revealed they were colonized with organisms that are quite distinct from H. pylori (Solnick et al, 2003). The bacterium most commonly seen is a large helical-shaped organism with three to eight turns (Baskerville & Newell, 1988;Curry et al, 1987;Henry et al, 1987;Lee et al, 1988). Dent et al (1987) reported the presence of these larger organisms in a small number of patients presenting with uppergastrointestinal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

O’Rourke

Solnick

Neilan

et al. 2004

International Journal of Systematic and Evolutionary Microbiology

128

166

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While Helicobacter pylori is accepted as the major bacterial agent of gastric disease in humans, some patients and many animals are infected with a larger, tightly helical-shaped bacterium previously referred to as ‘Helicobacter heilmannii’ or ‘Gastrospirillum hominis’. Taxonomic classification of these bacteria has been hampered by the inability to cultivate them in vitro and by the inadequate discriminatory power of 16S rRNA gene sequence analysis. This study describes the detection and phylogenetic analysis of 26 different gastrospirillum isolates from humans and animals, which incorporates sequence data based on the 16S rRNA and urease genes. Fifteen gastrospirilla detected in humans, primates and pigs clustered with ‘Candidatus Helicobacter suis’, thus expanding the host range for this organism. By comparison, based on 16S rRNA data, the remaining 11 gastrospirilla could not be differentiated from Helicobacter felis, Helicobacter bizzozeronii and Helicobacter salomonis. However, urease gene sequence analysis allowed for the discrimination of this latter group into four discrete clusters, three of which contained the above recognized species. The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name ‘Candidatus Helicobacter heilmannii’ is proposed.

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“…Until 1994, the only recognized non-human reservoirs for Helicobacter pylori were macaque species, especially rhesus monkeys and possibly baboons. [1][2][3][4][5][6][7] Although it has been known for decades that both dogs and cats harbour large gastric spiral organisms, [8][9][10] only recently have these organisms been identified by molecular techniques and named H. felis and H. heilmannii. 11,12 Other animals are also naturally colonized with Helicobacter spp.…”

Section: Introductionmentioning

confidence: 99%

**Local immune response in Helicobacter pylori‐infected cats and identification of H. pylori in saliva, gastric fluid and faeces**

et al. 1996

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SUMMARYHelicobacter pylori-infected cats were screened by culture and polymerase chain reaction (PCR) for the presence of H. pylori in salivary secretions, gastric juice, gastric tissue and faeces. H. pylori was cultured from salivary secretions in six of 12 (50%) cats and from gastric fluid samples in 11 of 12 (91%) cats. A 298 base pair polymerase chain reactions (PCR) product specific for an H. pylori 26 000 MW surface protein was amplified from dental plaque samples from five of 12 (42%) cats and from the faeces of four of five (80%)

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Spiral Organisms in the Baboon Stomach

Cited by 48 publications

References 3 publications

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes

**Local immune response in Helicobacter pylori‐infected cats and identification of H. pylori in saliva, gastric fluid and faeces**

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