Spirulina platensis alleviates high fat diet-induced cognitive impairment in mice via the gut-brain axis

Liu, Yan; Wang, Qiulian; Dou, Qingquan; Li, Xukai; Pan, Yinping; Meng, Lingzheng; Xue, Tong-Chun

doi:10.1016/j.jff.2021.104706

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…Our result was in harmony with, Venkateshappa et al, 55 which showed that GFAP expression rises with age, potentially making the brain more susceptible to neurotoxic assaults. In addition, Zhou et al, 56 revealed that Aspergillus platensis reduced GFAP levels via the gut-brain axis in high-fat-diet-induced memory loss in mice.…”

Section: Discussionmentioning

confidence: 99%

Arthrospira platensis Nanoparticles Mitigate Aging-Related Oxidative Injured Brain Induced by D-galactose in Rats Through Antioxidants, Anti-Inflammatory, and MAPK Pathways

Ghamry,

Shukry,

Kassab

et al. 2023

IJN

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Background Loss of normal function is an inevitable effect of aging. Several factors contribute to the aging process, including cellular senescence and oxidative stress. Methods We investigate how Arthrospira platensis Nanoparticles (NSP) protect against aging injury induced by d-galactose (D-gal) in the rat. So, we subcutaneously (S/C) injected D-gal at 200 mg/kg BW to see if Arthrospira platensis Nanoparticles (NSP) might protect against the oxidative changes generated by D-gal. NSP (0.5 mg/kg body weight once daily by gastric gavage) was given to all groups apart from the control and D-gal groups. The d-gal + NSP group was supplemented with 200 mg of D-gal per kg BW once a day and NSP 0.5 mg/kg BW given orally for 45 days. Biochemical, mRNA expression, and histological investigations of brain tissues were used to evaluate the oxidative alterations caused by d-gal and the protective role of NSP. Results Our data demonstrated that d-gal was causing significant reductions in relative brain and body weight with increased malondialdehyde (MDA) and redox oxygen species (ROS) levels and increases in serum creatine phosphokinase (CPK) and creatine phosphokinase isoenzyme BB (CPK-BB) with marked decreases in the level of antioxidant enzyme activity in the brain and acetylcholinesterase activity augmented with a phosphorylated H2A histone family member X (γ-H2AX) level increased. The D-gal group had considerably higher phosphorylated p38 mitogen-activated protein kinases (P38MAPK) and C-Jun N-terminal (JNK) kinases. The d-gal administration stimulates the apoptotic gene expression by downregulating the brain superoxide dismutase (SOD), catalase (CAT), and nuclear factor erythroid 2–related factor 2 (Nrf2). The NSP administration saved these parameters in the direction of the control. The brain histopathologic and immunohistochemistry analysis findings support our findings on NSP’s protective role. Conclusion The NSP may be a promising natural protective compound that can prevent aging and preserve health.

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Section: Discussionmentioning

confidence: 99%

Arthrospira platensis Nanoparticles Mitigate Aging-Related Oxidative Injured Brain Induced by D-galactose in Rats Through Antioxidants, Anti-Inflammatory, and MAPK Pathways

Ghamry,

Shukry,

Kassab

et al. 2023

IJN

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“…On the one hand, A. platensis inhibited amyloid‐β (Aβ) accumulation, tau‐hyperphosphorylation and neuroinflammation in neurons. On the other hand, A. platensis modulates the balance of the intestinal microflora, thus expressing a gut–brain modulatory effect (Zhou et al ., 2021). However, the beneficial components of A. platensis are harmful to the human body due to their poor targeting, which can produce various negative effects such as increased heart rate, blood pressure and insomnia (Müller et al ., 2021).…”

Section: Functional Properties Of Arthrospira Platensismentioning

confidence: 99%

Arthrospira platensis as future food: a review on functional ingredients, bioactivities and application in the food industry

Chang,

Liu

2023

Int J of Food Sci Tech

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SummaryThe coronavirus disease 2019 (COVID‐2019) pandemic and other factors have significantly increased the number of people suffering from food shortages worldwide in 2020. As many as 720–811 million people, which is nearly 10% of the global population, are facing hunger. Thus, the need for substances that fulfil human nutritional requirements is growing to address this issue. Arthrospira platensis (A. platensis), commonly or commercially called spirulina, is an ideal product that contains various functional ingredients. Given them, various health benefits of A. platensis are proven gradually, including anti‐oxidant, immune regulation, anti‐inflammation, hypoglycaemia, anti‐bacterial and anti‐radiation properties. In recent years, functional ingredients of A. platensis are showing the potential to be functional foods. This paper gives an overview on the functional ingredients and the resulting health benefits of A. platensis summarises the research progress of A. platensis as functional foods in recent years and looks forward to its application development prospects.

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“…In a study with Wistar rats treated with nicotine, a daily intraperitoneal injection with S. platensis-lipopolysaccharides (100 µg/kg) provided neuroprotection by suppressing the up-regulation of phosphorylatedtau ratio expression by two fold, while showcasing antioxidant, anti-inflammatory, and anti-apoptotic activities [78]. Dietary supplementation of 1% and 2% Spirulina platensis dry powder in high-fat diet mice lowered the tau burden by reducing both phosphorylated-tau and phosphorylated-GSK levels, while it also decreased Aβ 1-42 concentrations, APP, and BACE-1 levels in the hippocampus [79].…”

Section: Cyanobacteria Against Alzheimer's Diseasementioning

confidence: 99%

“…Growing data suggest that AD is associated with dysbiosis of the human gut microbiota via neuroinflammatory processes across the microbiota-gut-brain axis, suggesting that modifying the gut microbiota could be a strategy for treating the condition [84]. According to Zhou et al (2021) [79], dietary supplementation with 1% and 2% S. platensis dry powder in high-fat diet mice alleviated cognitive impairment and restored gut microbial dysbiosis by increasing the Shannon, ACE, and Chao indices while decreasing the Simpson index, indicating enhanced microbial community richness and diversity. It improved the intestinal environment by balancing microbiota and increasing the abundance of beneficial microorganisms, such as Verrucomicrobia, while reducing the presence of harmful microorganisms, like Firmicutes.…”

Section: Galizzi Et Al (2023)mentioning

confidence: 99%

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Ramos,

Reis,

Ferreira

et al. 2023

Biomolecules

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Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects.

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Spirulina platensis alleviates high fat diet-induced cognitive impairment in mice via the gut-brain axis

Cited by 13 publications

References 48 publications

Arthrospira platensis Nanoparticles Mitigate Aging-Related Oxidative Injured Brain Induced by D-galactose in Rats Through Antioxidants, Anti-Inflammatory, and MAPK Pathways

Arthrospira platensis Nanoparticles Mitigate Aging-Related Oxidative Injured Brain Induced by D-galactose in Rats Through Antioxidants, Anti-Inflammatory, and MAPK Pathways

Arthrospira platensis as future food: a review on functional ingredients, bioactivities and application in the food industry

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

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