Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress

Wang, Jian; Su, Liqian; Zhang, Lun; Zeng, Jiali; Chen, Qingru; Deng, Rui; Wang, Ziyan; Kuang, Weidong; Jin, Xiaobao; Gui, Shuiqing; Xu, Yi

doi:10.1631/jzus.b2100988

Cited by 22 publications

(4 citation statements)

References 53 publications

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“…The functions of gut microbiota in gastrointestinal and host health have been widely studied. , The bacteria in the colon can derive energy from the saccharolytic fermentation of nondigestible substrates and produce many nutrients and metabolites including SCFAs that can be absorbed into the bloodstream, thus reaching the whole-body tissue/organs. − SCFA is an important link between intestinal microbiota and the host. For intestinal health, SCFAs can serve as an energy source for intestinal epithelial cells, which can participate in intestinal mucosal immunity, inflammation, homeostasis, etc. , For systemic health, SCFAs can bind to receptors in many tissue/organs and act as hormone signals thus influencing the physiology or diseases of the nervous, endocrine, immune, and cardiovascular systems. − Importantly, the oral administration of ASX and SP has been reported to be beneficial to the gut microbiota composition and SCFAs production. ,,,− Besides, the SP@ASXnano could be fully degraded in the intestine (Figure D). Therefore, we speculated that SP@ASXnano might be utilized by gut microbiota, therefore influencing its composition and the fecal SCFAs levels.…”

Section: Resultsmentioning

confidence: 99%

Oral Microalgae-Nano Integrated System against Radiation-Induced Injury

Zhang

Cui

et al. 2023

ACS Nano

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The increasing applications of ionizing radiation in society raise the risk of radiation-induced intestinal and whole-body injury. Astaxanthin is a powerful antioxidant to reduce the reactive oxygen generated from radiation and the subsequent damage. However, the oral administration of astaxanthin remains challenging owing to its low solubility and poor bioavailability. Herein, we facilely construct an orally used microalgae-nano integrated system (SP@ASXnano) against radiation-induced intestinal and whole-body injury, combining natural microalgae Spirulina platensis (SP) with astaxanthin nanoparticles (ASXnano). SP and ASXnano show complementation in drug delivery to improve distribution in the intestine and blood. SP displays limited gastric drug loss, prolonged intestinal retention, constant ASXnano release, and progressive degradation. ASXnano improves drug solubility, gastric stability, cell uptake, and intestinal absorption. SP and ASXnano have synergy in many aspects such as anti-inflammation, microbiota protection, and fecal short-chain fatty acid up-regulation. In addition, the system is ensured with biosafety for long-term administration. The system organically combines the properties of microalgae and nanoparticles, which was expected to expand the medical application of SP as a versatile drug delivery platform.

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Section: Resultsmentioning

confidence: 99%

Oral Microalgae-Nano Integrated System against Radiation-Induced Injury

Zhang

Cui

et al. 2023

ACS Nano

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“…In addition, we observed changes in the gut microbiome in the Tibetan people of the plateau within one year after changes in their living condition; hence, these changes might play a crucial role in the alteration of gut flora. The factors affecting the alpha diversity and beta diversity of the gut microbiome in Tibetans and Han Chinese may include diet, genetic background, low oxygen, and low temperature ( Beam et al, 2021 ; Liang et al, 2021 ; Wang et al, 2022 ). Moreover, significant differences in microbial diversity and richness were observed among Tibetan regions at different altitudes ( Lan et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau

Zhang

Wang

Zhong

et al. 2023

J. Zhejiang Univ. Sci. B

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The gut microbiome shows changes under a plateau environment, while the disbalance of intestinal microbiota plays an important role in the pathogenesis of irritable bowel syndrome (IBS); however, the relationship between the two remains unexplored. In this work, we followed up a healthy cohort for up to a year before and after living in a plateau environment and performed 16S ribosomal RNA (rRNA) sequencing analysis of their fecal samples. Through evaluating the participants’ clinical symptoms, combined with an IBS questionnaire, we screened the IBS sub-population in our cohort. The sequencing results showed that a high-altitude environment could lead to changes in the diversity and composition of gut flora. In addition, we found that the longer the time volunteers spent in the plateau environment, the more similar their gut microbiota composition and abundance became compared to those before entering the plateau, and IBS symptoms were significantly alleviated. Therefore, we speculated that the plateau may be a special environment that induces IBS. The taxonomic units g_ Alistipes , g_ Oscillospira , and s_ Ruminococcus_torques , which had been proved to play important roles in IBS pathogenesis, were also abundant in the IBS cohort at high altitudes. Overall, the disbalance of gut microbiota induced by the plateau environment contributed to the high frequency of IBS and the psychosocial abnormalities associated with IBS. Our results prompt further research to elucidate the relevant mechanism.

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“…Inflammation and oxidative stress are closely linked. Inflammation triggers the production of free radicals, so intense inflammation will inevitably disrupt the redox balance of the body [53]. Excessive accumulation of ROS can cause oxidative damage to intracellular lipids, proteins, and DNA, which can also activate the pro-inflammatory signaling pathway to induce the release of pro-inflammatory cytokines thereby exacerbating inflammation [54]; the two are mutually reinforcing, and both would cause damage to the intestinal mechanical barrier and increase intestinal permeability, oxidative stress is an important factor in promoting the development of UC [55,56].…”

Section: Discussionmentioning

confidence: 99%

Rosa Roxburghii Tratt Fruit Extract Prevents Dss-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota and the IL-17 Signaling Pathway

Li,

Ling,

Huang

et al. 2023

Nutrients

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Ulcerative colitis (UC) is a non-specific inflammatory bowel illness characterized by intestinal mucosal barrier degradation, inflammation, oxidative damage, and gut microbiota imbalances. Rosa roxburghii Tratt Fruit extract (RRTE) was extracted from Rosa roxburghii Tratt fruit, exhibiting an excellent prevention effect against UC; RRTE could prevent the damage of DSS-induced human normal colonic epithelial (NCM 460) cells, especially in cell viability and morphology, and oxidative damage. Additionally, in UC mice, RRTE could limit the intestinal mucosal barrier by increasing the expression of intestinal tight junction proteins and mucin, reducing inflammation and oxidative damage in colon tissue. More importantly, RRTE can increase the abundance of beneficial bacteria to regulate gut microbiota such as Ruminococcus, Turicibacter, and Parabacteroides, and reduce the abundance of harmful bacteria such as Staphylococcus and Shigella. Furthermore, transcriptomics of colonic mucosal findings point out that the beneficial effect of RRTE on UC could be attributed to the modulation of inflammatory responses such as the IL-17 and TNF signaling pathways. The qPCR results confirm that RRTE did involve the regulation of several genes in the IL-17 signaling pathway. In conclusion, RRTE could prevent DSS-induced damage both in vitro and in vivo.

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Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress

Cited by 22 publications

References 53 publications

Oral Microalgae-Nano Integrated System against Radiation-Induced Injury

Oral Microalgae-Nano Integrated System against Radiation-Induced Injury

Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau

Rosa Roxburghii Tratt Fruit Extract Prevents Dss-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota and the IL-17 Signaling Pathway

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