Spitting out the demons: Extracellular vesicles in glioblastoma

André-Grégoire, Gwennan; Gavard, Julie

doi:10.1080/19336918.2016.1247145

Cited by 31 publications

(33 citation statements)

References 67 publications

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“…Therefore, it seems clear that, compared to a traditional diagnostic marker, exosomes should enhance, through a noninvasive approach, the synergic diagnostic activity of combined biomolecules [ 136 ]. Furthermore, their genetic and proteomic content should reflect the status of parental tumor cells and allow the identification of rapid changes in the tumor cell state and progress [ 137 ].…”

Section: Exosomes As Biomarker In the Glioma Diagnosismentioning

confidence: 99%

“…To date, miRNAs seem to have taken the lead in research as the most potential non-invasive diagnostic glioma biomarkers [ 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ] ( Table 3 ). For this reason, a great deal of effort has been spent on the establishment of exosomal miRNAs as glioma biomarkers.…”

Section: Exosomes As Biomarker In the Glioma Diagnosismentioning

confidence: 99%

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Exosomes in Gliomas: Biogenesis, Isolation, and Preliminary Applications in Nanomedicine

2020

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Exosomes are phospholipid-based particles endogenously produced by both normal and tumor cells. Initially identified as a pathway for shuttling cellular waste, for a long time they were thought to act as “garbage bags”, and only in the past few years have they emerged as a promising drug delivery system. In this review, we provide an overview of the knowledge about exosome architecture and biogenesis and the recent progress in isolation methods. Furthermore, we describe the mechanisms involved in both extra- and intracellular communication with a focus on glioma brain tumors. Glioma is considered a rare disease and is the most prominent aggressive brain malignancy. How exosomes target glial tumoral cells in vivo remains largely unknown. However, they are able to influence numerous physio-pathological aspects. Here, we discuss the role they play in this heterogeneous and complex microenvironment and their potential applications.

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Section: Exosomes As Biomarker In the Glioma Diagnosismentioning

confidence: 99%

Section: Exosomes As Biomarker In the Glioma Diagnosismentioning

confidence: 99%

Exosomes in Gliomas: Biogenesis, Isolation, and Preliminary Applications in Nanomedicine

2020

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“…An international consortium, however, agreed on the use of the term of extracellular vesicles (EVs) to uniform the confused terminology present in the literature [56,57].…”

Section: Role Of the Extracellular Vesicles In The Cross-talk Among Gmentioning

confidence: 99%

Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment

Ciccocioppo

Lanuti

Marchisio

et al. 2020

Journal of Oncology

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Glioblastoma (GBM) is the most deadly primary brain tumour and is a paradigmatic example of heterogeneous cancer. Although expanding data propose the phenotypic plasticity exhibited by glioblastoma cells, as a critical feature involved in the tumour development and posttherapy recurrence, the central machinery responsible for their aggressiveness remains elusive. Despite decades of research, the complex biology of the glioblastoma is still unknown. Progress in genetic and epigenetic discoveries has improved diagnostic classification, prognostic information, and therapeutic planning. In the complex model of intercellular signalling, several studies have shown that extracellular vesicles have a key role in the intercellular communication among GBM cells and the tumour microenvironment modulation. The purpose of this review is to summarize the role of the EV-mediated intercellular crosstalk in the glioblastoma physiopathology.

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“…In brief, the review "Splitting out the demons" is concerned about glioblastoma (620), but may well be of general relevance, particularly for PNI in PaCa. The authors demonstrate that the major signaling systems are NGF, axon guidance molecules, cytokines/chemokines, the cholinergic system, and matricellular proteins that are also delivered by several components of PaCa.…”

Section: Neural Invasion In Pancreatic Cancermentioning

confidence: 99%